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Ddb1
Gene Detail
 Symbol
Name
ID
Ddb1
damage specific DNA binding protein 1
MGI:1202384
Synonyms damage-specific DNA-binding protein, DNA repair, DNA repair protein, p127-Ddb1
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.66 cM, cytoband centromere
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:10605625-10629813 bp, + strand
From Ensembl annotation of GRCm38

  24189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: UV-damaged DNA-binding protein
Gene Tree: Ddb1

Human
homologs
Human Homolog DDB1, damage-specific DNA binding protein 1, 127kDa
NCBI Gene ID 1642
neXtProt AC  NX_Q16531
Human Synonyms  DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
Human Chr (Location)  11q12-q13; chr11:61299447-61333212 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Complete deletion of this gene results in embryonic lethality; conditional mutation causes increased apoptosis in the developing brain, and defects in lens formation.
 
Interactions
Ddb1 interacts with 128 markers (Mir15a, Mir15b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (4)    Tissues (3)    Images (1)
Theiler Stages: 17, 19
Assay TypeResults
RNA in situ 4
cDNA source data(18)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024740 (Evidence)
Entrez Gene13194 (Evidence)
DFCITC1573694, TC1594355, TC1677617
DoTSDT.101134025, DT.101214230, DT.101267382, DT.101406550, DT.102558593, DT.495939, DT.94380516, DT.99866666
NIA Mouse Gene IndexU019162
Consensus CDS ProjectCCDS37915.1
International Mouse Knockout Project StatusDdb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024740 Ensembl Gene Model | MGI Sequence Detail 24189 C57BL/6J ±  kb
transcript ENSMUST00000025649 Ensembl | MGI Sequence Detail 4155 Not Applicable 
polypeptide ENSMUSP00000025649 Ensembl | MGI Sequence Detail 1140 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000006340 DNA damage-binding protein 1
References (Earliest) J:46654 Fernandes M, et al., The mouse homologs of human GIF, DDB1, and CFL1 genes are located on chromosome 19. Mamm Genome. 1998 Apr;9(4):339
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(46)
Other
accession IDs
MGI:2147436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory