Gene Ontology Classifications

Symbol
Name
ID

Ddb1
damage specific DNA binding protein 1
MGI:1202384

Go Annotations as Summary Text (Tabular View) (GO Graph)

Automated description from the Alliance of Genome Resources (Release 8.3.0)

Predicted to enable WD40-repeat domain binding activity; cullin family protein binding activity; and protein-macromolecule adaptor activity. Predicted to contribute to damaged DNA binding activity and ubiquitin ligase complex scaffold activity. Involved in several processes, including cellular response to UV; positive regulation of gluconeogenesis; and ubiquitin-dependent protein catabolic process. Acts upstream of or within Wnt signaling pathway and negative regulation of apoptotic process. Part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including blastocyst; early embryo; germ cell of gonad; otocyst; and spleen. Human ortholog(s) of this gene implicated in communication disorder. Orthologous to human DDB1 (damage specific DNA binding protein 1).

Go Annotations in Tabular Form (Text View) (GO Graph)

Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Filter

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/31/2026 MGI 6.24