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Birc3
Gene Detail
Symbol

Name
ID
Birc3
baculoviral IAP repeat-containing 3
MGI:1197007
Synonyms
Api2, cIAP2, cIAP-2, HIAP2, IAP2, MIAP2, MIHC, RNF49
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:7848699-7873186 bp, - strand
From VEGA annotation of GRCm38

  24488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: BIRC3
Protein SuperFamily: inhibitor of apoptosis protein with CARD domain
Gene Tree: Birc3

Human
homologs
BIRC3, baculoviral IAP repeat containing 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 330
neXtProt AC: NX_Q13489

Human Synonyms: AIP1, API2, c-IAP2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49

Human Chr (Location): 11q22; chr11:102317373-102339403 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a reduced susceptibility to endotoxic shock. Mice homozygous for a knock-in allele exhibit increased B cell survival and proliferation, lymph node hyperplasia, lymphocytic infiltrates in the lungs, and enlarged gut-associated lympoid tissue.
 
Interactions
Birc3 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(114)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(2) cDNA(114)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020585 (Evidence)
Ensembl Gene Model ENSMUSG00000032000 (Evidence)
Entrez Gene 11796 (Evidence)
UniGene 2026
DFCI TC1589149, TC1576230, TC1613959
DoTS DT.99852284, DT.530695, DT.55146167, DT.524548, DT.101393796
NIA Mouse Gene Index U030448
EC 6.3.2.-
Consensus CDS Project CCDS22812.2
International Mouse Phenotyping Consortium Status Birc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020585 VEGA Gene Model | MGI Sequence Detail 24488 C57BL/6J ±  kb
transcript OTTMUST00000048783 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000022461 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000004752 baculoviral IAP repeat-containing protein 3
References
(Earliest) J:45561 Liston P, et al., Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. Genomics. 1997 Dec 15;46(3):495-503
(Latest) J:221325 Ebert G, et al., Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5797-802
All references(69)
Other
accession IDs
MGI:2143290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory