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Birc3 Gene Detail
Summary
  • Symbol
    Birc3
  • Name
    baculoviral IAP repeat-containing 3
  • Synonyms
    Api2, cIAP2, cIAP-2, HIAP2, IAP2, MIAP2, MIHC, RNF49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197007
    NCBI Gene: 11796
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BIRC3, baculoviral IAP repeat containing 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BIRC3, baculoviral IAP repeat containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIP1, API2, c-IAP2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49
  • Links
    NCBI Gene ID: 330
    neXtProt AC: NX_Q13489
    UniProt: Q13489

  • Chr Location
    11q22.2; chr11:102317450-102339403 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a reduced susceptibility to endotoxic shock. Mice homozygous for a knock-in allele exhibit increased B cell survival and proliferation, lymph node hyperplasia, lymphocytic infiltrates in the lungs, and enlarged gut-associated lympoid tissue.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020585 VEGA Gene Model | MGI Sequence Detail 24488 C57BL/6J ±  kb
    transcript OTTMUST00000048783 VEGA | MGI Sequence Detail 2667 Not Applicable  
    polypeptide OTTMUSP00000022461 VEGA | MGI Sequence Detail 602 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      69 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 117
      Genomic 2
      cDNA 115

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143290
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:30406 Rothe M, et al., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52
    • Latest
      J:260804 Annibaldi A, et al., Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018 Feb 15;69(4):566-580.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory