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Birc3
Gene Detail
Symbol

Name
ID
Birc3
baculoviral IAP repeat-containing 3
MGI:1197007
Synonyms
Api2, cIAP2, cIAP-2, HIAP2, IAP2, MIAP2, MIHC, RNF49
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:7848699-7873186 bp, - strand
From VEGA annotation of GRCm38

  24488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: inhibitor of apoptosis protein with CARD domain
Gene Tree: Birc3

Human
homologs
Human Homolog   BIRC3, baculoviral IAP repeat containing 3
NCBI Gene ID 330
neXtProt AC  NX_Q13489
Human Synonyms  AIP1, API2, c-IAP2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49
Human Chr (Location)  11q22; chr11:102317373-102339403 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a reduced susceptibility to endotoxic shock. Mice homozygous for a knock-in allele exhibit increased B cell survival and proliferation, lymph node hyperplasia, lymphocytic infiltrates in the lungs, and enlarged gut-associated lympoid tissue.
 
Interactions
Birc3 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(114)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(2) cDNA(114)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020585 (Evidence)
Ensembl Gene ModelENSMUSG00000032000 (Evidence)
Entrez Gene11796 (Evidence)
UniGene2026
DFCITC1613959, TC1589149, TC1576230
DoTSDT.530695, DT.524548, DT.101393796, DT.55146167, DT.99852284
NIA Mouse Gene IndexU030448
EC6.3.2.-
Consensus CDS ProjectCCDS22812.2
International Mouse Knockout Project StatusBirc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020585 VEGA Gene Model | MGI Sequence Detail 24488 C57BL/6J ±  kb
transcript OTTMUST00000048783 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000022461 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000004752 baculoviral IAP repeat-containing protein 3
References
(Earliest) J:30406 Rothe M, et al., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52
(Latest) J:215110 Guicciardi ME, et al., Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One. 2014;9(3):e92124
All references(70)
Other
accession IDs
MGI:2143290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory