About   Help   FAQ
Kdm1a Gene Detail
Summary
  • Symbol
    Kdm1a
  • Name
    lysine (K)-specific demethylase 1A
  • Synonyms
    1810043O07Rik, Aof2, Kdm1, LSD1, mKIAA0601
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196256
    NCBI Gene: 99982
  • Gene Overview
    MyGene.info: KDM1A
Location & Maps
more
  • Sequence Map
    Chr4:136550540-136602723 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52184 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.80 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KDM1A, lysine demethylase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDM1A, lysine demethylase 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOF2, BHC110, CPRF, KDM1, LSD1
  • Links
    NCBI Gene ID: 23028
    neXtProt AC: NX_O60341

  • Chr Location
    1p36.12; chr1:23019443-23083691 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KDM1A associations

Human Disease Mouse Models
       Cleft Palate, Psychomotor Retardation, and Distinctive Facial Features; CPRF   OMIM: 616728
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 7 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    2
  • Gene trapped
    23
  • Targeted
    10
  • Genomic Mutations
    3 involving Kdm1a
  • Incidental Mutations
Mice homozygous for a null allele exhibit early embryonic lethality (E7.5) due to failure of egg cylinder elongation, and failure to gastrulate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009707 VEGA Gene Model | MGI Sequence Detail 52184 C57BL/6J ±  kb
transcript OTTMUST00000022415 VEGA | MGI Sequence Detail 3028 Not Applicable  
polypeptide OTTMUSP00000010218 VEGA | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    448 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 8
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917041, MGI:2140140
References
more
  • Summaries
    All 74
    Developmental Gene Expression 14
    Gene Ontology 15
    Phenotypes 26
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:230604 Lambrot R, et al., The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors. FASEB J. 2015 Nov;29(11):4402-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory