About   Help   FAQ
Kdm1a
Gene Detail
 Symbol
Name
ID
Kdm1a
lysine (K)-specific demethylase 1A
MGI:1196256
Synonyms 1810043O07Rik, Aof2, Kdm1, LSD1, mKIAA0601
Feature Type protein coding gene
Genetic Map
Chromosome 4
68.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:136550540-136602723 bp, - strand
From VEGA annotation of GRCm38

  52184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32240  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lysine-specific histone demethylase
Gene Tree: Kdm1a

Human
homologs
Human Homolog KDM1A, lysine (K)-specific demethylase 1A
NCBI Gene ID 23028
neXtProt AC  NX_O60341
Human Synonyms  AOF2, BHC110, KDM1, LSD1
Human Chr (Location)  1p36.12; chr1:23019443-23083691 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(23) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit early embryonic lethality (E7.5) due to failure of egg cylinder elongation, and failure to gastrulate.
 
Interactions
Kdm1a interacts with 85 markers (Mir1b, Mir7-1, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process cell proliferation, chromatin modification, ...
Component nuclear chromatin, nucleus, ...
Function androgen receptor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (764)    Tissues (555)    Images (26)
Theiler Stages: 17, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 750
Northern blot 8
RT-PCR 4
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009707 (Evidence)
Ensembl Gene ModelENSMUSG00000036940 (Evidence)
Entrez Gene99982 (Evidence)
DFCITC1575093, TC1707543
DoTSDT.101735445, DT.103566206, DT.535757, DT.55188073
NIA Mouse Gene IndexU025670
EC1.-.-.-
Consensus CDS ProjectCCDS51331.1
International Mouse Knockout Project StatusKdm1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009707 VEGA Gene Model | MGI Sequence Detail 52184 C57BL/6J ±  kb
transcript OTTMUST00000022415 VEGA | MGI Sequence Detail 3028 Not Applicable 
polypeptide OTTMUSP00000010218 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(452 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002937 Amine oxidase
InterPro IPR017366 Histone lysine-specific demethylase
InterPro IPR009057 Homeodomain-like
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR007526 SWIRM domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000004088 lysine-specific histone demethylase 1A
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:206436 Zhu D, et al., Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun. 2014;5:3174
All references(62)
Other
accession IDs
MGI:1917041, MGI:2140140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory