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Kdm1a Gene Detail
Summary
  • Symbol
    Kdm1a
  • Name
    lysine (K)-specific demethylase 1A
  • Synonyms
    1810043O07Rik, Aof2, Kdm1, LSD1, mKIAA0601
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196256
    NCBI Gene: 99982
  • Gene Overview
    MyGene.info: KDM1A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136550540-136602723 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    448 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196256
protein coding gene Chr4:136550533-136602790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028969
protein coding gene Chr4:139128954-139181019 (-)
A/J MGP_AJ_G0028928
protein coding gene Chr4:133188185-133240972 (-)
AKR/J MGP_AKRJ_G0028880
protein coding gene Chr4:137035289-137088663 (-)
BALB/cJ MGP_BALBcJ_G0028952
protein coding gene Chr4:133857254-133909780 (-)
C3H/HeJ MGP_C3HHeJ_G0028666
protein coding gene Chr4:137324398-137376836 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029393
protein coding gene Chr4:144093822-144148435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026664
protein coding gene Chr4:126226888-126281292 (-)
CAST/EiJ MGP_CASTEiJ_G0028098
protein coding gene Chr4:135480459-135535453 (-)
CBA/J MGP_CBAJ_G0028631
protein coding gene Chr4:148041679-148098545 (-)
DBA/2J MGP_DBA2J_G0028780
protein coding gene Chr4:133602859-133655647 (-)
FVB/NJ MGP_FVBNJ_G0028747
protein coding gene Chr4:132553095-132605895 (-)
LP/J MGP_LPJ_G0028879
protein coding gene Chr4:139209101-139263888 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028773
protein coding gene Chr4:152213654-152272612 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029431
protein coding gene Chr4:137519260-137573606 (-)
PWK/PhJ MGP_PWKPhJ_G0027818
protein coding gene Chr4:130386480-130439131 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027644
protein coding gene Chr4:133308847-133363584 (-)
WSB/EiJ MGP_WSBEiJ_G0028176
protein coding gene Chr4:137672491-137725736 (-)



Homology
more
  • Human Ortholog
    KDM1A, lysine demethylase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDM1A, lysine demethylase 1A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AOF2, BHC110, CPRF, KDM1, LSD1
  • Links
    NCBI Gene ID: 23028
    neXtProt AC: NX_O60341
    UniProt: O60341

  • Chr Location
    1p36.12; chr1:23019443-23083691 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in abnormal gastrulation and early embryonic lethality. Homozygotes lacking the neurospecific isoform are hypoexcitable and display decreased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036940 Ensembl Gene Model | MGI Sequence Detail 52184 C57BL/6J ±  kb
    transcript ENSMUST00000105847 Ensembl | MGI Sequence Detail 3028 Not Applicable  
    polypeptide ENSMUSP00000101473 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 10
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917041, MGI:2140140
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 18
      Gene Ontology 23
      Phenotypes 40
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:262214 Okuno Y, et al., Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway. Diabetes. 2018 Jun;67(6):1113-1127

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory