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Eda
Gene Detail
 Symbol
Name
ID
Eda
ectodysplasin-A
MGI:1195272
Synonyms Ed1, EDA1, Eda-A1, Eda-A2
Feature Type protein coding gene
Genetic Map
Chromosome X
43.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(94)
Sequence Map
ChrX:99975606-100400762 bp, + strand
From VEGA annotation of GRCm38

  425157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68180  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Eda

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Chemically and radiation induced(2) Chemically induced (ENU)(2) Radiation induced(5) Spontaneous(14) Targeted(1)
 
Mutant hemizygous males and homozygous females have defects in ectodermal derivatives with absence of guard hairs, zigzags and tail hair, reduced eyelid opening, fewer vibrissae and defects of teeth and exocrine glands. Homozygous females are often sterile.
 
Human Diseases Modeled Using Mouse Eda (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Eda interacts with 432 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell differentiation, cell-matrix adhesion, ...
Component apical part of cell, collagen trimer, ...
Function tumor necrosis factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (145)    Tissues (93)    Images (59)
Theiler Stages: 7, 8, 10, 11, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
Assay TypeResults
RNA in situ 132
Northern blot 8
Western blot 4
RT-PCR 1
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(10) cDNA(27) Primer pair(1) Other(3)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000018058 (Evidence)
Ensembl Gene ModelENSMUSG00000059327 (Evidence)
Entrez Gene13607 (Evidence)
UniGene328086
DFCITC1587613, TC1596605, TC1597485, TC1599213, TC1653046
DoTSDT.101713740, DT.111023308, DT.111023309, DT.111023327, DT.55281652, DT.91323351, DT.94242826, DT.94242835
NIA Mouse Gene IndexU020049
Consensus CDS ProjectCCDS30299.1, CCDS53141.1, CCDS53142.1, CCDS53143.1, CCDS53144.1, CCDS53145.1
International Mouse Knockout Project StatusEda
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018058 VEGA Gene Model | MGI Sequence Detail 425157 C57BL/6J ±  kb
transcript OTTMUST00000043583 VEGA | MGI Sequence Detail 4955 Not Applicable 
polypeptide OTTMUSP00000019583 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(20) UniProt(6)
Polymorphisms SNPs within 2kb(934 from dbSNP Build 137)    SNPs within 2kb including multiple locations(940)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR006052 Tumour necrosis factor
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000006886 ectodysplasin-A
References (Earliest) J:78116 Falconer DS, et al., The environment in relation to selection for size in mice. J Genet. 1952;51:67-80
(Latest) J:196301 Cottle DL, et al., c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis. Cell Rep. 2013 Feb 21;3(2):427-41
All references(207)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-14700, MGI:98473

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory