Eda
Gene Detail

Symbol Name ID

Eda ectodysplasin-A MGI:1195272

Synonyms

Ed1, EDA1, Eda-A1, Eda-A2

Feature Type

protein coding gene

Genetic Map

Chromosome X

43.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(94)

Sequence Map

ChrX:99975606-100400762 bp, + strand From VEGA annotation of GRCm38   425157 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eda

Human homologs

Human Homolog		EDA, ectodysplasin A
NCBI Gene ID		1896
neXtProt AC		NX_Q92838
Human Synonyms		ECTD1, ED1, ED1-A1, ED1-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED
Human Chr (Location)		Xq12-q13.1; chrX:68835911-69259322 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human EDA

Alleles and phenotypes

All alleles(23) : Targeted(1) Spontaneous(13) Chemically induced(4) Radiation induced(7)
 

Mutant hemizygous males and homozygous females have defects in ectodermal derivatives with absence of guard hairs, zigzags and tail hair, reduced eyelid opening, fewer vibrissae and defects of teeth and exocrine glands. Homozygous females are often sterile.

 
Human Diseases Modeled Using Mouse Eda (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cell differentiation, cell-matrix adhesion, ...
Component	apical part of cell, collagen, ...
Function	receptor binding, tumor necrosis factor receptor binding

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (131)    Tissues (83)    Images (55)
Theiler Stages: 7, 8, 10, 11, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	118
Northern blot	8
Western blot	4
RT-PCR	1

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(10) cDNA(27) Primer pair(1) Other(3)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000018058 (Evidence)
Ensembl Gene Model	ENSMUSG00000059327 (Evidence)
Entrez Gene	13607 (Evidence)
UniGene	328086
DFCI	TC1587613, TC1596605, TC1597485, TC1599213, TC1653046
DoTS	DT.101713740, DT.111023308, DT.111023309, DT.111023327, DT.55281652, DT.91323351, DT.94242826, DT.94242835
NIA Mouse Gene Index	U020049
Consensus CDS Project	CCDS30299.1, CCDS53141.1, CCDS53142.1, CCDS53143.1, CCDS53144.1, CCDS53145.1
International Mouse Knockout Project Status	Eda

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018058	VEGA Gene Model | MGI Sequence Detail	425157	C57BL/6J
transcript	OTTMUST00000043583	VEGA | MGI Sequence Detail	4955	Not Applicable
polypeptide	OTTMUSP00000019583	VEGA | MGI Sequence Detail	391	Not Applicable

All sequences(100) RefSeq(18) UniProt(6)

Polymorphisms

SNPs(796 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000006886	ectodysplasin-A

References

(Earliest) J:78116 Falconer DS, et al., The environment in relation to selection for size in mice. J Genet. 1952;51:67-80
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(206)

Other accession IDs

MGD-MRK-14700, MGI:98473