Phenotypes Associated with This Genotype

Genotype
MGI:8209647

• Allelic Composition: Eda^em2Ywu/Eda^em2Ywu
• Genetic Background: C57BL/6J-Eda^em2Ywu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

taurodontia ( J:363034 )

♀ • the lower second molar exhibits taurodontism

abnormal molar cusp morphology ( J:363034 )

♀ • although 3 mandibular molars are present, the first lower molar is small with only four or normal seven cusps formed

small molars ( J:363034 )

♀ • the lower first molars are smaller

endocrine/exocrine glands

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • mice exhibit very few sweat glands in the footpads

hypohidrosis ( J:363034 )

♀ • mice show defective sweating function

growth/size/body

taurodontia ( J:363034 )

♀ • the lower second molar exhibits taurodontism

abnormal molar cusp morphology ( J:363034 )

♀ • although 3 mandibular molars are present, the first lower molar is small with only four or normal seven cusps formed

small molars ( J:363034 )

♀ • the lower first molars are smaller

integument

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • mice exhibit very few sweat glands in the footpads

hypohidrosis ( J:363034 )

♀ • mice show defective sweating function

sparse hair ( J:363034 )

♀ • scanty abdomen hair, ear hair, and hair around the eyes, but normal tail hair and tips

limbs/digits/tail

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • mice exhibit very few sweat glands in the footpads

skeleton

taurodontia ( J:363034 )

♀ • the lower second molar exhibits taurodontism

abnormal molar cusp morphology ( J:363034 )

♀ • although 3 mandibular molars are present, the first lower molar is small with only four or normal seven cusps formed

small molars ( J:363034 )

♀ • the lower first molars are smaller

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ectodermal dysplasia 1		DOID:0111664	OMIM:305100	J:363034