Phenotypes Associated with This Genotype

Genotype
MGI:8209646

• Allelic Composition: Eda^em4Ywu/Eda^em4Ywu
• Genetic Background: C57BL/6J-Eda^em4Ywu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

taurodontia ( J:363034 )

♀ • the lower second molar shows a high incidence of taurodontism with a large pulp chamber

decreased molar number ( J:363034 )

♀ • mice have only two mandibular molars with the third molar missing

embryo

abnormal ectoderm morphology ( J:363034 )

♀ • mice exhibit ectodermal dysplasia

endocrine/exocrine glands

absent eccrine glands ( J:363034 )

♀ • mice exhibit no eccrine sweat glands in the footpads

hypohidrosis ( J:363034 )

♀ • mice show a severe defect in sweating ability

growth/size/body

taurodontia ( J:363034 )

♀ • the lower second molar shows a high incidence of taurodontism with a large pulp chamber

decreased molar number ( J:363034 )

♀ • mice have only two mandibular molars with the third molar missing

integument

absent eccrine glands ( J:363034 )

♀ • mice exhibit no eccrine sweat glands in the footpads

hypohidrosis ( J:363034 )

♀ • mice show a severe defect in sweating ability

sparse hair ( J:363034 )

♀ • mice have hairless tails and abdomen, a bald patch behind ears, and scant hair around the eyes

limbs/digits/tail

absent eccrine glands ( J:363034 )

♀ • mice exhibit no eccrine sweat glands in the footpads

hairless tail ( J:363034 )

♀

kinked tail ( J:363034 )

♀

skeleton

taurodontia ( J:363034 )

♀ • the lower second molar shows a high incidence of taurodontism with a large pulp chamber

decreased molar number ( J:363034 )

♀ • mice have only two mandibular molars with the third molar missing

vision/eye

abnormal eyelid development ( J:363034 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ectodermal dysplasia 1		DOID:0111664	OMIM:305100	J:363034