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Hdgfl1 Gene Detail
Summary
  • Symbol
    Hdgfl1
  • Name
    HDGF like 1
  • Synonyms
    Hdgfrp1, HRP-1, Pwwp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194493
    NCBI Gene: 15192
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:26952156-26954148 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.09 cM, cytoband A3.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194493
protein coding gene Chr13:26952155-26954148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020389
protein coding gene Chr13:24347509-24349448 (-)
A/J MGP_AJ_G0020338
protein coding gene Chr13:23848817-23850766 (-)
AKR/J MGP_AKRJ_G0020318
protein coding gene Chr13:24131535-24133478 (-)
BALB/cJ MGP_BALBcJ_G0020336
protein coding gene Chr13:23817458-23819408 (-)
C3H/HeJ MGP_C3HHeJ_G0020140
protein coding gene Chr13:24202344-24204287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020773
protein coding gene Chr13:25173817-25175756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018361
protein coding gene Chr13:22504022-22505968 (-)
CAST/EiJ MGP_CASTEiJ_G0019657
protein coding gene Chr13:23940709-23942678 (-)
CBA/J MGP_CBAJ_G0020094
protein coding gene Chr13:26174076-26176014 (-)
DBA/2J MGP_DBA2J_G0020220
protein coding gene Chr13:23368441-23370390 (-)
FVB/NJ MGP_FVBNJ_G0020204
protein coding gene Chr13:22970876-22972820 (-)
LP/J MGP_LPJ_G0020293
protein coding gene Chr13:24604876-24606822 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020231
protein coding gene Chr13:26497940-26499930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020815
protein coding gene Chr13:23986640-23988580 (-)
PWK/PhJ MGP_PWKPhJ_G0019411
protein coding gene Chr13:23341694-23343635 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019227
protein coding gene Chr13:22866462-22868414 (-)
WSB/EiJ MGP_WSBEiJ_G0019717
protein coding gene Chr13:24162858-24164882 (-)



Homology
more
  • Human Ortholog
    HDGFL1, HDGF like 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDGFL1, HDGF like 1
  • Synonyms
    dJ309H15.1, Hdgfrp1, HRP-1, PWWP1
  • Links
    NCBI Gene ID: 154150
    neXtProt AC: NX_Q5TGJ6
    UniProt: Q5TGJ6

  • Chr Location
    6p22.3; chr6:22569449-22570521 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045835 Ensembl Gene Model | MGI Sequence Detail 1993 C57BL/6J ±  kb
    transcript ENSMUST00000055915 Ensembl | MGI Sequence Detail 1993 Not Applicable  
    polypeptide ENSMUSP00000057557 Ensembl | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR035496 HDGF-related, PWWP domain
      IPR000313 PWWP domain
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 6
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:293870 Sun J, et al., CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction. Biol Reprod. 2020 Aug 4;103(2):183-194

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/16/2021
    MGI 6.17
    The Jackson Laboratory