Hdgfl1 MGI Mouse Gene Detail - MGI:1194493

Symbol

Hdgfl1
Name

HDGF like 1
Synonyms

Hdgfrp1, HRP-1, Pwwp1

Feature Type

protein coding gene
IDs

MGI:1194493
NCBI Gene: 15192
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:26952156-26954148 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 12.09 cM, cytoband A3.3
Mapping Data

1 experiment

SNPs within 2kb

20 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194493	protein coding gene	Chr13:26952155-26954148 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020389	protein coding gene	Chr13:24347509-24349448 (-)
A/J	MGP_AJ_G0020338	protein coding gene	Chr13:23848817-23850766 (-)
AKR/J	MGP_AKRJ_G0020318	protein coding gene	Chr13:24131535-24133478 (-)
BALB/cJ	MGP_BALBcJ_G0020336	protein coding gene	Chr13:23817458-23819408 (-)
C3H/HeJ	MGP_C3HHeJ_G0020140	protein coding gene	Chr13:24202344-24204287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020773	protein coding gene	Chr13:25173817-25175756 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018361	protein coding gene	Chr13:22504022-22505968 (-)
CAST/EiJ	MGP_CASTEiJ_G0019657	protein coding gene	Chr13:23940709-23942678 (-)
CBA/J	MGP_CBAJ_G0020094	protein coding gene	Chr13:26174076-26176014 (-)
DBA/2J	MGP_DBA2J_G0020220	protein coding gene	Chr13:23368441-23370390 (-)
FVB/NJ	MGP_FVBNJ_G0020204	protein coding gene	Chr13:22970876-22972820 (-)
LP/J	MGP_LPJ_G0020293	protein coding gene	Chr13:24604876-24606822 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020231	protein coding gene	Chr13:26497940-26499930 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020815	protein coding gene	Chr13:23986640-23988580 (-)
PWK/PhJ	MGP_PWKPhJ_G0019411	protein coding gene	Chr13:23341694-23343635 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019227	protein coding gene	Chr13:22866462-22868414 (-)
WSB/EiJ	MGP_WSBEiJ_G0019717	protein coding gene	Chr13:24162858-24164882 (-)

Human Ortholog

HDGFL1, HDGF like 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDGFL1, HDGF like 1
Synonyms

dJ309H15.1, Hdgfrp1, HRP-1, PWWP1
Links

HGNC:21095

NCBI Gene ID: 154150

neXtProt AC: NX_Q5TGJ6

UniProt: Q5TGJ6
Chr Location

6p22.3; chr6:22569566-22571666 (+) GRCh38

MGI Vertebrate Homology

Hdgfl1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: HDGFL1
Gene Tree

Hdgfl1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Genomic Mutations

2 involving Hdgfl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice exhibit normal male fertility.

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

6
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS26388.1

Ensembl

ENSMUSG00000045835 (Evidence)
NCBI Gene

15192

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045835	Ensembl Gene Model \| MGI Sequence Detail	1993	C57BL/6J	± kb
transcript	ENSMUST00000055915	Ensembl \| MGI Sequence Detail	1993	Not Applicable
polypeptide	ENSMUSP00000057557	Ensembl \| MGI Sequence Detail	283	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR000313 PWWP domain

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All nucleic 16

cDNA 16

Microarray probesets 6

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:293870 Sun J, et al., CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction. Biol Reprod. 2020 Aug 4;103(2):183-194

TSS for Hdgfl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121832	Chr13:26954140-26954157 (-)	-1 bp
Tssr121831	Chr13:26954110-26954133 (-)	26 bp
Tssr121830	Chr13:26954093-26954102 (-)	50 bp
Tssr121829	Chr13:26954078-26954087 (-)	65 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23