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Slc32a1
Gene Detail
 Symbol
Name
ID
Slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
MGI:1194488
Synonyms R75019, VGAT, Viaat
Feature Type protein coding gene
Genetic Map
Chromosome 2
78.72 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:158610767-158615748 bp, + strand
From VEGA annotation of GRCm38

  4982 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc32a1

Human
homologs
Human Homolog SLC32A1, solute carrier family 32 (GABA vesicular transporter), member 1
NCBI Gene ID 140679
neXtProt AC  NX_Q9H598
Human Synonyms  VGAT, VIAAT
Human Chr (Location)  20q11.23; chr20:38724462-38729372 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice been independently reported to die perinatally exhibiting a hunched posture, respiratory failure, cleft secondary palate due to failure of palate shelf elevation, umbilical hernia or omphalocele, and loss of neurotransmitter release in both GABAergic and glycinergic neurons.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process gamma-aminobutyric acid transport, glycine transport, ...
Component cell tip, cone cell pedicle, ...
Function gamma-aminobutyric acid:proton symporter activity, glycine transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (372)    Tissues (191)    Images (59)
Theiler Stages: 13, 15, 16, 17, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 351
Northern blot 1
RT-PCR 12
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(16) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015925 (Evidence)
Ensembl Gene ModelENSMUSG00000037771 (Evidence)
Entrez Gene22348 (Evidence)
Consensus CDS ProjectCCDS38309.1
International Mouse Knockout Project StatusSlc32a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015925 VEGA Gene Model | MGI Sequence Detail 4982 C57BL/6J ±  kb
transcript OTTMUST00000037831 VEGA | MGI Sequence Detail 2797 Not Applicable 
polypeptide OTTMUSP00000016986 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013057 Amino acid transporter, transmembrane
Protein Ontology PR:000015084 vesicular inhibitory amino acid transporter
References (Earliest) J:44006 Sagne C, et al., Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett. 1997 Nov 10;417(2):177-83
(Latest) J:210610 Martin C, et al., Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23;34(17):6047-56
All references(97)
Other
accession IDs
MGI:2139541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory