Slc32a1
Gene Detail

Symbol Name ID

Slc32a1 solute carrier family 32 (GABA vesicular transporter), member 1 MGI:1194488

Synonyms

R75019, VGAT, Viaat

Feature Type

protein coding gene

Genetic Map

Chromosome 2

78.72 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:158610767-158615748 bp, + strand From VEGA annotation of GRCm38   4982 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc32a1

Human homologs

Human Homolog		SLC32A1, solute carrier family 32 (GABA vesicular transporter), member 1
NCBI Gene ID		140679
neXtProt AC		NX_Q9H598
Human Synonyms		VGAT, VIAAT
Human Chr (Location)		20q11.23; chr20:37353105-37358015 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null mice been independently reported to die perinatally exhibiting a hunched posture, respiratory failure, cleft secondary palate due to failure of palate shelf elevation, umbilical hernia or omphalocele, and loss of neurotransmitter release in both GABAergic and glycinergic neurons.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	amino acid transmembrane transport, gamma-aminobutyric acid transport, ...
Component	cell tip, cone cell pedicle, ...
Function	gamma-aminobutyric acid:hydrogen symporter activity, glycine transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (41 records)
Data Summary: Results (372)    Tissues (191)    Images (59)
Theiler Stages: 13, 15, 16, 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	351
Northern blot	1
RT-PCR	12

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(16) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015925 (Evidence)
Ensembl Gene Model	ENSMUSG00000037771 (Evidence)
Entrez Gene	22348 (Evidence)
Consensus CDS Project	CCDS38309.1
International Mouse Knockout Project Status	Slc32a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015925	VEGA Gene Model | MGI Sequence Detail	4982	C57BL/6J
transcript	OTTMUST00000037831	VEGA | MGI Sequence Detail	2797	Not Applicable
polypeptide	OTTMUSP00000016986	VEGA | MGI Sequence Detail	525	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013057	Amino acid transporter, transmembrane
Protein Ontology	PR:000015084	vesicular inhibitory amino acid transporter

References

(Earliest) J:44006 Sagne C, et al., Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett. 1997 Nov 10;417(2):177-83
(Latest) J:192687 Summa M, et al., Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. 2013 Mar;66:215-24
All references(85)

Other accession IDs

MGI:2139541