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Slc32a1
Gene Detail
Symbol

Name
ID
Slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
MGI:1194488
Synonyms
R75019, VGAT, Viaat
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.72 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:158610767-158615748 bp, + strand
From VEGA annotation of GRCm38

  4982 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC32A1
Gene Tree: Slc32a1

Human
homologs
SLC32A1, solute carrier family 32 (GABA vesicular transporter), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 140679
neXtProt AC: NX_Q9H598

Human Synonyms: VGAT, VIAAT

Human Chr (Location): 20q11.23; chr20:38724462-38729372 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice been independently reported to die perinatally exhibiting a hunched posture, respiratory failure, cleft secondary palate due to failure of palate shelf elevation, umbilical hernia or omphalocele, and loss of neurotransmitter release in both GABAergic and glycinergic neurons.
 
Phenotype Images(2)
Interactions
Slc32a1 interacts with 155 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (51 records)
Data Summary: Results (372)    Tissues (192)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 351
Northern blot 1
RT-PCR 12
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc32a1    NEW 
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(16) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015925 (Evidence)
Ensembl Gene Model ENSMUSG00000037771 (Evidence)
Entrez Gene 22348 (Evidence)
Consensus CDS Project CCDS38309.1
International Mouse Phenotyping Consortium Status Slc32a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015925 VEGA Gene Model | MGI Sequence Detail 4982 C57BL/6J ±  kb
transcript OTTMUST00000037831 VEGA | MGI Sequence Detail 2797 Not Applicable 
polypeptide OTTMUSP00000016986 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013057 Amino acid transporter, transmembrane
Protein Ontology PR:000015084 vesicular inhibitory amino acid transporter
References
(Earliest) J:44006 Sagne C, et al., Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett. 1997 Nov 10;417(2):177-83
(Latest) J:219852 Wu Z, et al., GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015 Feb 25;35(8):3312-8
All references(117)
Other
accession IDs
MGI:2139541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory