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Slc32a1 Gene Detail
Summary
  • Symbol
    Slc32a1
  • Name
    solute carrier family 32 (GABA vesicular transporter), member 1
  • Synonyms
    R75019, VGAT, Viaat
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194488
    NCBI Gene: 22348
  • Gene Overview
    MyGene.info: SLC32A1
Location & Maps
more
  • Sequence Map
    Chr2:158610767-158615748 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4982 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM, cytoband H1-3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC32A1, solute carrier family 32 member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC32A1, solute carrier family 32 member 1
    Orthology source: HomoloGene
  • Synonyms
    VGAT, VIAAT
  • Links
    NCBI Gene ID: 140679
    neXtProt AC: NX_Q9H598

  • Chr Location
    20q11.23; chr20:38724462-38729372 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Incidental Mutations
Homozygous null mice been independently reported to die perinatally exhibiting a hunched posture, respiratory failure, cleft secondary palate due to failure of palate shelf elevation, umbilical hernia or omphalocele, and loss of neurotransmitter release in both GABAergic and glycinergic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015925 VEGA Gene Model | MGI Sequence Detail 4982 C57BL/6J ±  kb
transcript OTTMUST00000037831 VEGA | MGI Sequence Detail 2797 Not Applicable  
polypeptide OTTMUSP00000016986 VEGA | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015084 vesicular inhibitory amino acid transporter
  • InterPro Domains
    IPR013057 Amino acid transporter, transmembrane domain
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 16
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGI:2139541
References
more
  • Summaries
    All 128
    Developmental Gene Expression 52
    Gene Ontology 10
    Phenotypes 44
  • Earliest
    J:44006 Sagne C, et al., Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett. 1997 Nov 10;417(2):177-83
  • Latest
    J:231730 Yu S, et al., Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci. 2016 May 4;36(18):5034-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory