Phenotypes Associated with This Genotype

Genotype
MGI:6730293

• Allelic Composition: Slc32a1^tm2(cre)Lowl/Slc32a1^tm2(cre)Lowl
• Genetic Background: either: B6J.129S6(FVB)-Slc32a1^tm2(cre)Lowl or (involves: 129S6/SvEvTac * C57BL/6J * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased kindling response ( J:308516 )

• mice develop spontaneous recurring limbic seizures about 1 week after electrical kindling, although in some cases seizures began before mice were fully kindled

tonic-clonic seizures ( J:308516 )

• electrical kindling induces spontaneous recurring seizures after a short latency in about 80% of mice; seizures occur 1-2 times per day and most are bilateral, tonic-clonic seizures

• however, no to little neuronal death is seen

abnormal inhibitory postsynaptic currents ( J:308516 )

• spontaneous IPSCs show a decrease in amplitude in CA1 neurons and dentate granule cells, with an average decrease of 23% in CA1 neurons

• however, no differences in spontaneous IPSC rise time, decay rate, or frequency are seen

behavior/neurological

increased kindling response ( J:308516 )

• mice develop spontaneous recurring limbic seizures about 1 week after electrical kindling, although in some cases seizures began before mice were fully kindled

tonic-clonic seizures ( J:308516 )

• electrical kindling induces spontaneous recurring seizures after a short latency in about 80% of mice; seizures occur 1-2 times per day and most are bilateral, tonic-clonic seizures

• however, no to little neuronal death is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
temporal lobe epilepsy		DOID:3328	OMIM:PS600512	J:308516