Phox2b
Gene Detail

Symbol Name ID

Phox2b paired-like homeobox 2b MGI:1100882

Synonyms

Dilp1, GENA 269, NBPhox, Phox2b, Pmx2b

Feature Type

protein coding gene

Genetic Map

Chromosome 5

35.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:67094397-67099301 bp, - strand From VEGA annotation of GRCm38   4905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Phox2b

Human homologs

Human Homolog		PHOX2B, paired-like homeobox 2b
NCBI Gene ID		8929
neXtProt AC		NX_Q99453
Human Synonyms		NBLST2, NBPhox, PMX2B
Human Chr (Location)		4p12; chr4:41746099-41750987 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PHOX2B

Alleles and phenotypes

All alleles(12) : Targeted(11) Chemically induced(1)
 

Heterozygotes for an ethylnitrosourea-induced mutation exhibit dilated pupils and reduced preweaning viability. Other mice heterozygous for mutations in this gene exhibit respiratory failure and specific loss of parafacial interneurons. Homozygotes are inviable.

 
Human Diseases Modeled Using Mouse Phox2b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	autonomic nervous system development, cell development, ...
Component	nuclear chromatin, nucleus
Function	DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (146 records)
Data Summary: Results (369)    Tissues (218)    Images (98)
Theiler Stages: 2, 3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	47
RNA in situ	272
In situ reporter (knock in)	14
RT-PCR	36

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(15) Primer pair(3) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037720 (Evidence)
Ensembl Gene Model	ENSMUSG00000012520 (Evidence)
Entrez Gene	18935 (Evidence)
UniGene	62505
DFCI	TC1584224, TC1594294
DoTS	DT.101720690, DT.110638665, DT.60102029
NIA Mouse Gene Index	U026264
Consensus CDS Project	CCDS19316.1
International Mouse Knockout Project Status	Phox2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037720	VEGA Gene Model | MGI Sequence Detail	4905	C57BL/6J
transcript	OTTMUST00000097414	VEGA | MGI Sequence Detail	3015	Not Applicable
polypeptide	OTTMUSP00000054637	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000012672	paired mesoderm homeobox protein 2B

References

(Earliest) J:43772 Pattyn A, et al., Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development. 1997 Oct;124(20):4065-75
(Latest) J:195264 Vincentz JW, et al., Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
All references(186)

Other accession IDs

MGI:1890532