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Phox2b
Gene Detail
 Symbol
Name
ID
Phox2b
paired-like homeobox 2b
MGI:1100882
Synonyms Dilp1, GENA 269, NBPhox, Phox2b, Pmx2b
Feature Type protein coding gene
Genetic Map
Chromosome 5
35.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:67094397-67099249 bp, - strand
From VEGA annotation of GRCm38

  4853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68371  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Phox2b

Human
homologs
Human Homolog PHOX2B, paired-like homeobox 2b
NCBI Gene ID 8929
neXtProt AC  NX_Q99453
Human Synonyms  NBLST2, NBPhox, PMX2B
Human Chr (Location)  4p12; chr4:41744082-41748970 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PHOX2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygotes for an ethylnitrosourea-induced mutation exhibit dilated pupils and reduced preweaning viability. Other mice heterozygous for mutations in this gene exhibit respiratory failure and specific loss of parafacial interneurons. Homozygotes are inviable.
 
Human Diseases Modeled Using Mouse Phox2b (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Phox2b interacts with 252 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process autonomic nervous system development, cell development, ...
Component nuclear chromatin, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (157 records)
Data Summary: Results (429)    Tissues (233)    Images (150)
Theiler Stages: 2, 3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 92
RNA in situ 287
In situ reporter (knock in) 14
RT-PCR 36
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(15) Primer pair(3) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037720 (Evidence)
Ensembl Gene ModelENSMUSG00000012520 (Evidence)
Entrez Gene18935 (Evidence)
UniGene62505
DFCITC1584224, TC1594294
DoTSDT.101720690, DT.110638665, DT.60102029
NIA Mouse Gene IndexU026264
Consensus CDS ProjectCCDS19316.1
International Mouse Knockout Project StatusPhox2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037720 VEGA Gene Model | MGI Sequence Detail 4853 C57BL/6J ±  kb
transcript OTTMUST00000097414 VEGA | MGI Sequence Detail 2963 Not Applicable 
polypeptide OTTMUSP00000054637 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012672 paired mesoderm homeobox protein 2B
References (Earliest) J:43772 Pattyn A, et al., Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development. 1997 Oct;124(20):4065-75
(Latest) J:208408 Prin F, et al., Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation. Development. 2014 Apr;141(7):1492-502
All references(197)
Disease annotation references (1)
Other
accession IDs
MGI:1890532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/08/2014
MGI 5.18
The Jackson Laboratory