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Dnah11
Gene Detail
Symbol

Name
ID
Dnah11
dynein, axonemal, heavy chain 11
MGI:1100864
Synonyms
b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, b2b598Clo, Dnahc11, lrd
Feature Type
protein coding gene
Genetic Map
Chromosome 12
63.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr12:117877982-118199043 bp, - strand
From VEGA annotation of GRCm38

  321062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2801  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 western clawed frog

HCOP human homology predictions: DNAH11
Protein SuperFamily: dynein heavy chain, ciliary
Gene Tree: Dnah11

Human
homologs
DNAH11, dynein, axonemal, heavy chain 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8701
neXtProt AC: NX_Q96DT5

Human Synonyms: CILD7, DNAHBL, DNAHC11, DNHBL, DPL11

Human Chr (Location): 7p21; chr7:21543215-21901568 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNAH11

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(9) Gene trapped(2) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.
 
Human Diseases Modeled in Mice Using Dnah11 (2)    Mutations Annotated to Human Diseases (8)    Phenotype Images(116)
Interactions
Dnah11 interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cilium movement, determination of left/right symmetry, ...
Component motile primary cilium
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (3)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 2
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(8) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000040132 (Evidence)
Ensembl Gene Model ENSMUSG00000018581 (Evidence)
Entrez Gene 13411 (Evidence)
UniGene 390540
DFCI TC1587727
DoTS DT.101287107, DT.94267822
NIA Mouse Gene Index U034463
Consensus CDS Project CCDS36578.1
International Mouse Phenotyping Consortium Status Dnah11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040132 VEGA Gene Model | MGI Sequence Detail 321062 C57BL/6J ±  kb
transcript OTTMUST00000104272 VEGA | MGI Sequence Detail 14072 Not Applicable 
polypeptide OTTMUSP00000058337 VEGA | MGI Sequence Detail 4488 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(28) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(2432 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2434)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR011704 ATPase, dynein-related, AAA domain
InterPro IPR026983 Dynein heavy chain
InterPro IPR030443 Dynein heavy chain 11, axonemal
InterPro IPR024743 Dynein heavy chain, coiled coil stalk
InterPro IPR004273 Dynein heavy chain domain
InterPro IPR013594 Dynein heavy chain, domain-1
InterPro IPR013602 Dynein heavy chain, domain-2
InterPro IPR024317 Dynein heavy chain, P-loop containing D4 domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006557 dynein heavy chain 11, axonemal
References
(Earliest) J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(83)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11512, MGI:5311338, MGI:5311353, MGI:5311358, MGI:5437063, MGI:5437717, MGI:96625

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory