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Dnah11
Gene Detail
 Symbol
Name
ID
Dnah11
dynein, axonemal, heavy chain 11
MGI:1100864
Synonyms b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, b2b598Clo, Dnahc11, lrd
Feature Type protein coding gene
Genetic Map
Chromosome 12
63.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr12:117877982-118199043 bp, - strand
From VEGA annotation of GRCm38

  321062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2801  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog

Protein SuperFamily: dynein heavy chain, ciliary
Gene Tree: Dnah11

Human
homologs
Human Homolog DNAH11, dynein, axonemal, heavy chain 11
NCBI Gene ID 8701
neXtProt AC  NX_Q96DT5
Human Synonyms  CILD7, DNAHBL, DNAHC11, DNHBL, DPL11
Human Chr (Location)  7p21; chr7:21543215-21901568 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNAH11
Alleles
and
phenotypes
All alleles(16) : Chemically induced (ENU)(9) Gene trapped(2) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.
 
Human Diseases Modeled Using Mouse Dnah11 (2)    Alleles Annotated to Human Diseases(8)    Phenotype Images(107)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cilium movement, determination of left/right symmetry
Function ATP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (3)    Tissues (2)    Images (2)
Theiler Stages: 11, 26
Assay TypeResults
RNA in situ 1
RT-PCR 2
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(30) Genomic(8) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000040132 (Evidence)
Ensembl Gene ModelENSMUSG00000018581 (Evidence)
Entrez Gene13411 (Evidence)
UniGene390540
DFCITC1587727
DoTSDT.101287107, DT.94267822
NIA Mouse Gene IndexU034463
Consensus CDS ProjectCCDS36578.1
International Mouse Knockout Project StatusDnah11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040132 VEGA Gene Model | MGI Sequence Detail 321062 C57BL/6J ±  kb
transcript OTTMUST00000104272 VEGA | MGI Sequence Detail 14072 Not Applicable 
polypeptide OTTMUSP00000058337 VEGA | MGI Sequence Detail 4488 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(24) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(2432 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2434)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR011704 ATPase, dynein-related, AAA domain
InterPro IPR026983 Dynein heavy chain
InterPro IPR024743 Dynein heavy chain, coiled coil stalk
InterPro IPR004273 Dynein heavy chain domain
InterPro IPR013594 Dynein heavy chain, domain-1
InterPro IPR013602 Dynein heavy chain, domain-2
InterPro IPR024317 Dynein heavy chain, P-loop containing D4 domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006557 dynein heavy chain 11, axonemal
References (Earliest) J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
(Latest) J:195164 Takao D, et al., Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Dev Biol. 2013 Apr 1;376(1):23-30
All references(83)
Other
accession IDs
MGD-MRK-11512, MGI:5311338, MGI:5311353, MGI:5311358, MGI:5437063, MGI:5437717, MGI:96625

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory