Dnahc11
Gene Detail

Symbol Name ID

Dnahc11 dynein, axonemal, heavy chain 11 MGI:1100864

Synonyms

b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, b2b598Clo, lrd

Feature Type

protein coding gene

Genetic Map

Chromosome 12

63.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr12:117877982-118199043 bp, - strand From VEGA annotation of GRCm38   321062 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2801  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 zebrafish

Protein SuperFamily: dynein heavy chain, ciliary
Gene Tree: Dnahc11

Human homologs

Human Homolog		DNAH11, dynein, axonemal, heavy chain 11
NCBI Gene ID		8701
neXtProt AC		NX_Q96DT5
Human Synonyms		CILD7, DNAHBL, DNAHC11, DNHBL, DPL11
Human Chr (Location)		7p21; chr7:21582833-21941457 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DNAH11

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(2) Spontaneous(1) Chemically induced(8)
 

Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.

 
Human Diseases Modeled Using Mouse Dnahc11 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(69)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	ciliary or flagellar motility, determination of left/right symmetry, ...
Component	axonemal dynein complex, cilium
Function	ATP binding, microtubule motor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (3)    Tissues (2)    Images (1)
Theiler Stages: 11, 26

Assay Type	Results
RNA in situ	1
RT-PCR	2

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(8) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000040132 (Evidence)
Ensembl Gene Model	ENSMUSG00000018581 (Evidence)
Entrez Gene	13411 (Evidence)
UniGene	390540
DFCI	TC1587727
DoTS	DT.101287107, DT.94267822
NIA Mouse Gene Index	U034463
Consensus CDS Project	CCDS36578.1
International Mouse Knockout Project Status	Dnahc11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040132	VEGA Gene Model | MGI Sequence Detail	321062	C57BL/6J
transcript	OTTMUST00000104272	VEGA | MGI Sequence Detail	14072	Not Applicable
polypeptide	OTTMUSP00000058337	VEGA | MGI Sequence Detail	4488	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(1881 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR011704	ATPase, dynein-related, AAA domain
InterPro	IPR024743	Dynein heavy chain, coiled coil stalk
InterPro	IPR004273	Dynein heavy chain domain
InterPro	IPR013594	Dynein heavy chain, domain-1
InterPro	IPR013602	Dynein heavy chain, domain-2
InterPro	IPR024317	Dynein heavy chain, P-loop containing D4 domain
Protein Ontology	PR:000006557	dynein heavy chain 11, axonemal

References

(Earliest) J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
(Latest) J:182770 Bisgrove BW, et al., RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol. 2012 Mar 1;363(1):166-78
All references(81)

Other accession IDs

MGD-MRK-11512, MGI:5311338, MGI:5311353, MGI:5311358, MGI:5437063, MGI:5437717, MGI:96625