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Dnah11 Gene Detail
Summary
  • Symbol
    Dnah11
  • Name
    dynein, axonemal, heavy chain 11
  • Synonyms
    b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, b2b598Clo, Dnahc11, lrd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100864
    NCBI Gene: 13411
  • Gene Overview
    MyGene.info: DNAH11
Location & Maps
more
  • Sequence Map
    Chr12:117877982-118199043 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      321062 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DNAH11, dynein axonemal heavy chain 11
  • Vertebrate Orthologs
    5
  • Human Ortholog
    DNAH11, dynein axonemal heavy chain 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CILD7, DNAHBL, DNAHC11, DNHBL, DPL11
  • Links
    NCBI Gene ID: 8701
    neXtProt AC: NX_Q96DT5

  • Chr Location
    7p21; chr7:21543215-21901568 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Dnah11 mouse models; 1 with human DNAH11 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 7; CILD7   OMIM: 611884 View 8 models
       Heterotaxy, Visceral, 1, X-Linked; HTX1   OMIM: 306955 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 14 alleles in 14 genetic backgrounds
    119 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    10
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    4
  • Incidental Mutations
Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040132 VEGA Gene Model | MGI Sequence Detail 321062 C57BL/6J ±  kb
transcript OTTMUST00000104272 VEGA | MGI Sequence Detail 14072 Not Applicable  
polypeptide OTTMUSP00000058337 VEGA | MGI Sequence Detail 4488 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2397 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011704 ATPase, dynein-related, AAA domain
    IPR026983 Dynein heavy chain
    IPR030443 Dynein heavy chain 11, axonemal
    IPR024743 Dynein heavy chain, coiled coil stalk
    IPR004273 Dynein heavy chain domain
    IPR013594 Dynein heavy chain, domain-1
    IPR013602 Dynein heavy chain, domain-2
    IPR024317 Dynein heavy chain, P-loop containing D4 domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 30
    Genomic 8
    cDNA 18
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-11512, MGI:5311338, MGI:5311353, MGI:5311358, MGI:5437063, MGI:5437717, MGI:96625
References
more
  • Summaries
    All 79
    Developmental Gene Expression 11
    Diseases 2
    Gene Ontology 5
    Phenotypes 46
  • Earliest
    J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory