Phenotypes Associated with This Genotype

Genotype
MGI:5437752

• Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo
• Genetic Background: C57BL/6J-Dnah11^b2b1727Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1727-002-LA displays heterotaxy indicated by dextrocardia with lung lobation and levogastria

cardiovascular system

right aortic arch ( J:175213 )

double outlet right ventricle, ventricular defect committed to aorta ( J:175213 )

atrioventricular septal defect ( J:175213 )

growth/size/body

heterotaxia ( J:175213 )

renal/urinary system

hydronephrosis ( J:175213 )

respiratory system

abnormal respiratory motile cilium physiology ( J:175213 )

• immotile/hyperkinetic/dyskinetic respiratory airway cilia

immotile respiratory cilia ( J:175213 )

abnormal respiration ( J:175213 )

hematopoietic system

spleen hypoplasia ( J:175213 )

• hypoplastic/abnormal spleen

immune system

spleen hypoplasia ( J:175213 )

• hypoplastic/abnormal spleen

cellular

abnormal respiratory motile cilium physiology ( J:175213 )

• immotile/hyperkinetic/dyskinetic respiratory airway cilia

immotile respiratory cilia ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia 7		DOID:0110605	OMIM:611884	J:175213
visceral heterotaxy		DOID:0050545	OMIM:PS306955	J:175213