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Med1
Gene Detail
 Symbol
Name
ID
Med1
mediator complex subunit 1
MGI:1100846
Synonyms CRSP210, DRIP205, l11Jus15, PBP, Pparbp, TRAP220, TRAP 220
Feature Type protein coding gene
Genetic Map
Chromosome 11
61.75 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:98152154-98193293 bp, - strand
From VEGA annotation of GRCm38

  41140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: mediator of RNA polymerase II transcription, subunit 1, metazoan type
Gene Tree: Med1

Human
homologs
Human Homolog MED1, mediator complex subunit 1
NCBI Gene ID 5469
neXtProt AC  NX_Q15648
Human Synonyms  CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Human Chr (Location)  17q12; chr17:39404285-39451274 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(24) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have defects of placental vasculature, heart, and lens, arrested erythrocytic differentiation, impaired neuronal development, and die by embryonic day 11.5.
 
Phenotype Images(5)
Interactions
Med1 interacts with 421 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (116 annotations)
Process androgen biosynthetic process, androgen receptor signaling pathway, ...
Component chromatin, mediator complex, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (107)    Tissues (77)    Images (18)
Theiler Stages: 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 73
Northern blot 24
RT-PCR 10
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000002636 (Evidence)
Ensembl Gene ModelENSMUSG00000018160 (Evidence)
Entrez Gene19014 (Evidence)
DFCITC1578859, TC1580858, TC1595112, TC1677366, TC1683941, TC1708623
NIA Mouse Gene IndexU033361
PDB1XDK
Consensus CDS ProjectCCDS25341.1, CCDS36300.1
International Mouse Knockout Project StatusMed1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002636 VEGA Gene Model | MGI Sequence Detail 41140 C57BL/6J ±  kb
transcript OTTMUST00000005143 VEGA | MGI Sequence Detail 8024 Not Applicable 
polypeptide OTTMUSP00000002443 VEGA | MGI Sequence Detail 1575 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(15) UniProt(2)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019680 Mediator complex, subunit Med1, metazoa/fungi
Protein Ontology PR:000010279 mediator of RNA polymerase II transcription subunit 1
References (Earliest) J:43438 Zhu Y, et al., Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6
(Latest) J:211423 Matsui K, et al., Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin beta gene promoter. Biochem Biophys Res Commun. 2013 Oct 11;440(1):184-9
All references(90)
Other
accession IDs
MGI:2144192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory