Med1^tm2Jkr
Targeted Allele Detail

Summary

• Symbol: Med1^tm2Jkr
• Name: mediator complex subunit 1; targeted mutation 2, Janardan K Reddy
• MGI ID: MGI:3511276
• Synonyms: Med1^fl, PBP^fl
• Gene: Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Med1^tm2Jkr page

Heart sections of Med1^tm2Jkr/Med1^tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94123
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was introduced in intron 7 and a floxed neomycin cassette was placed in intron 10. The neomycin cassette was later deleted by breeding to EIIa-cre mice leaving exons 8, 9, and 10 flanked by loxP sites. (J:94123)

Disease models

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	5 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med1 Mutation: 61 strains or lines available

References

• Original: J:94123 Jia Y, et al., Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 4;279(23):24427-34
• All: 29 reference(s)