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Targeted Allele Detail
Symbol: Med1tm2Jkr
Name: mediator complex subunit 1; targeted mutation 2, Janardan K Reddy
MGI ID: MGI:3511276
Synonyms: Med1fl, PBPfl
Gene: Med1  Location: Chr11:98042980-98084119 bp, - strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Med1tm2Jkr page
Heart sections of Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:94123
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA single loxP site was introduced in intron 7 and a floxed neomycin cassette was placed in intron 10. The neomycin cassette was later deleted by breeding to EIIa-cre mice leaving exons 8, 9, and 10 flanked by loxP sites. (J:94123)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 34 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Med1 Mutation:  61 strains or lines available
Original:  J:94123 Jia Y, et al., Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 4;279(23):24427-34
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory