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Myt1l Gene Detail
Summary
  • Symbol
    Myt1l
  • Name
    myelin transcription factor 1-like
  • Synonyms
    2900046C06Rik, 2900093J19Rik, C630034G21Rik, mKIAA1106, Nztf1, Pmng1, Png-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100511
    NCBI Gene: 17933
Location & Maps
more
  • Sequence Map
    Chr12:29528384-29923209 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      394826 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYT1L, myelin transcription factor 1 like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYT1L, myelin transcription factor 1 like
    Orthology source: HomoloGene
  • Synonyms
    MRD39, NZF1, ZC2H2C2, ZC2HC4B
  • Links
    NCBI Gene ID: 23040
    neXtProt AC: NX_Q9UL68

  • Chr Location
    2p25.3; chr2:1789113-2331375 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7435
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MYT1L
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYT1L associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 39; MRD39   OMIM: 616521
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061911 Ensembl Gene Model | MGI Sequence Detail 394826 C57BL/6J ±  kb
transcript ENSMUST00000049784 Ensembl | MGI Sequence Detail 7198 Not Applicable  
polypeptide ENSMUSP00000058264 Ensembl | MGI Sequence Detail 1187 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4261 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010893 myelin transcription factor 1-like protein
  • InterPro Domains
    IPR013681 Myelin transcription factor 1
    IPR002515 Zinc finger, C2HC-type
Molecular
Reagents
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  • All nucleic 28
    cDNA 25
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-36441, MGI:107864, MGI:1920146, MGI:1920316, MGI:2443117, MGI:891972
References
more
  • Summaries
    All 44
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
  • Latest
    J:228310 Camp JG, et al., Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15672-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory