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Kcnj8 Gene Detail
Summary
  • Symbol
    Kcnj8
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 8
  • Synonyms
    gnite, Kir6.1, slmbr, sltr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100508
    NCBI Gene: 16523
  • Gene Overview
    MyGene.info: KCNJ8
Location & Maps
more
  • Sequence Map
    Chr6:142564837-142571614 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6778 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCNJ8, potassium voltage-gated channel subfamily J member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNJ8, potassium voltage-gated channel subfamily J member 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIR6.1, uKATP-1
  • Links
    NCBI Gene ID: 3764
    neXtProt AC: NX_Q15842

  • Chr Location
    12p11.23; chr12:21764955-21775502 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    4
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Kcnj8
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit sudden cardiac death due to dysregulation of the vascular tonus in the coronary arteries, and exhibit a phenotype resembling Prinzmetal (or variant) angina in humans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057136 VEGA Gene Model | MGI Sequence Detail 6778 C57BL/6J ±  kb
transcript OTTMUST00000140693 VEGA | MGI Sequence Detail 2548 Not Applicable  
polypeptide OTTMUSP00000073639 VEGA | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001984 ATP-sensitive inward rectifier potassium channel 8
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003278 Potassium channel, inwardly rectifying, Kir6.1
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 32
    cDNA 30
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2141411, MGI:3626329, MGI:3626331, MGI:3626333
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:43481 Isomoto S, et al., Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Mamm Genome. 1997 Oct;8(10):790-1
  • Latest
    J:213304 Nichols CG, et al., KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013 Mar 29;112(7):1059-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory