About   Help   FAQ
Kcnj8
Gene Detail
 Symbol
Name
ID
Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
MGI:1100508
Synonyms gnite, Kir6.1, slmbr, sltr
Feature Type protein coding gene
Genetic Map
Chromosome 6
74.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:142564939-142571356 bp, - strand
From NCBI annotation of GRCm38

  6418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj8

Human
homologs
Human Homolog KCNJ8, potassium inwardly-rectifying channel, subfamily J, member 8
NCBI Gene ID 3764
neXtProt AC  NX_Q15842
Human Synonyms  KIR6.1, uKATP-1
Human Chr (Location)  12p11.23; chr12:21764955-21775566 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(4) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit sudden cardiac death due to dysregulation of the vascular tonus in the coronary arteries, and exhibit a phenotype resembling Prinzmetal (or variant) angina in humans.
 
Interactions
Kcnj8 interacts with 100 markers (Mir7-2, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process defense response to virus, heart development, ...
Component ATP-sensitive potassium channel complex, integral component of membrane, ...
Function ATP-activated inward rectifier potassium channel activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (49)    Tissues (42)    Images (8)
Theiler Stages: 17, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 43
RT-PCR 6
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030247 (Evidence)
Entrez Gene16523 (Evidence)
UniGene1482
DFCITC1582553, TC1588318, TC1679154
DoTSDT.490606, DT.99855033
NIA Mouse Gene IndexU028006
Consensus CDS ProjectCCDS20685.1
International Mouse Knockout Project StatusKcnj8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16523 NCBI Gene Model | MGI Sequence Detail 6418 C57BL/6J ±  kb
transcript NM_008428 RefSeq | MGI Sequence Detail 2188 C57BL/6 
polypeptide P97794 UniProt | EBI | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003278 Potassium channel, inwardly rectifying, Kir6.1
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001984 ATP-sensitive inward rectifier potassium channel 8
Graphical View of Protein Domain Structure
References (Earliest) J:43481 Isomoto S, et al., Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Mamm Genome. 1997 Oct;8(10):790-1
(Latest) J:149169 Benamer N, et al., Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol. 2009 Apr;46(4):508-17
All references(46)
Other
accession IDs
MGI:2141411, MGI:3626329, MGI:3626331, MGI:3626333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory