Kcnj8
Gene Detail

Symbol Name ID

Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 MGI:1100508

Synonyms

gnite, Kir6.1, slmbr, sltr

Feature Type

protein coding gene

Genetic Map

Chromosome 6

74.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:142564939-142571356 bp, - strand From NCBI annotation of GRCm38   6418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj8

Human homologs

Human Homolog		KCNJ8, potassium inwardly-rectifying channel, subfamily J, member 8
NCBI Gene ID		3764
neXtProt AC		NX_Q15842
Human Synonyms		KIR6.1, uKATP-1
Human Chr (Location)		12p11.23; chr12:21917889-21927755 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Spontaneous(1) Chemically induced(4)
 

Mice homozygous for a targeted null mutation exhibit sudden cardiac death due to dysregulation of the vascular tonus in the coronary arteries, and exhibit a phenotype resembling Prinzmetal (or variant) angina in humans.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	defense response to virus, heart development, ...
Component	ATP-sensitive potassium channel complex, integral to membrane, ...
Function	ATP-activated inward rectifier potassium channel activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (49)    Tissues (40)    Images (8)
Theiler Stages: 17, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	43
RT-PCR	6

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030247 (Evidence)
Entrez Gene	16523 (Evidence)
UniGene	1482
DFCI	TC1582553, TC1588318, TC1679154
DoTS	DT.490606, DT.99855033
NIA Mouse Gene Index	U028006
Consensus CDS Project	CCDS20685.1
International Mouse Knockout Project Status	Kcnj8

Sequences

Length	Strain/Species
genomic	16523	NCBI Gene Model | MGI Sequence Detail	6418	C57BL/6J
transcript	NM_008428	RefSeq | MGI Sequence Detail	2188	C57BL/6
polypeptide	P97794	UniProt | EBI | MGI Sequence Detail	424	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003278	Potassium channel, inwardly rectifying, Kir6.1
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000001984	ATP-sensitive inward rectifier potassium channel 8

Graphical View of Protein Domain Structure

References

(Earliest) J:43481 Isomoto S, et al., Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Mamm Genome. 1997 Oct;8(10):790-1
(Latest) J:149169 Benamer N, et al., Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol. 2009 Apr;46(4):508-17
All references(46)

Other accession IDs

MGI:2141411, MGI:3626329, MGI:3626331, MGI:3626333