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Kif5b Gene Detail
Summary
  • Symbol
    Kif5b
  • Name
    kinesin family member 5B
  • Synonyms
    Khc, kinesin heavy chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098268
    NCBI Gene: 16573
  • Gene Overview
    MyGene.info: KIF5B
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:6201005-6241524 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.46 cM, cytoband A2-B1
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098268
protein coding gene Chr18:6201002-6242174 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024129
protein coding gene Chr18:3090294-3132137 (-)
A/J MGP_AJ_G0024091
protein coding gene Chr18:3082035-3123044 (-)
AKR/J MGP_AKRJ_G0024059
protein coding gene Chr18:3154500-3195727 (-)
BALB/cJ MGP_BALBcJ_G0024091
protein coding gene Chr18:3059810-3100522 (-)
C3H/HeJ MGP_C3HHeJ_G0023856
protein coding gene Chr18:3053232-3096197 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024536
protein coding gene Chr18:3288991-3330342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021975
protein coding gene Chr18:2863911-2900038 (-)
CAST/EiJ MGP_CASTEiJ_G0023335
protein coding gene Chr18:3080491-3138802 (-)
CBA/J MGP_CBAJ_G0023830
protein coding gene Chr18:3222353-3264350 (-)
DBA/2J MGP_DBA2J_G0023958
protein coding gene Chr18:2987299-3030085 (-)
FVB/NJ MGP_FVBNJ_G0023924
protein coding gene Chr18:2962847-3005198 (-)
LP/J MGP_LPJ_G0024042
protein coding gene Chr18:3104222-3148193 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023952
protein coding gene Chr18:3285931-3330243 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024581
protein coding gene Chr18:3027718-3073072 (-)
PWK/PhJ MGP_PWKPhJ_G0023080
protein coding gene Chr18:2986564-3029889 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022891
protein coding gene Chr18:3338402-3381453 (-)
WSB/EiJ MGP_WSBEiJ_G0023401
protein coding gene Chr18:3072209-3115884 (-)



Homology
more
  • Human Ortholog
    KIF5B, kinesin family member 5B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KIF5B, kinesin family member 5B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-61, KINH, KNS, KNS1, UKHC
  • Links
    NCBI Gene ID: 3799
    neXtProt AC: NX_P33176
    UniProt: P33176

  • Chr Location
    10p11.22; chr10:32009010-32056443 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos during organogenesis, exhibit growth retardation and fail to turn during gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16573 NCBI Gene Model | MGI Sequence Detail 40520 C57BL/6J ±  kb
    transcript NM_008448 RefSeq | MGI Sequence Detail 6030 C57BL/6  
    polypeptide Q61768 UniProt | EBI | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2147285
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 21
      Phenotypes 14
    • Earliest
      J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
    • Latest
      J:247032 Cui J, et al., Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity. FASEB J. 2017 Jun;31(6):2533-2547

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory