Kif5b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kif5b
kinesin family member 5B
MGI:1098268

18 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kif5b^tm1.1Njen/Kif5b^tm1.1Njen involves: 129S1/Sv	preweaning lethality, complete penetrance	J:170887
Kif5b^tm1Njen/Kif5b⁺ Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL	decreased insulin secretion	J:170198
	impaired glucose tolerance	J:170198
Kif5b^tm1Njen/Kif5b^tm1.1Njen Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL	abnormal pancreas physiology	J:170198
	abnormal pancreatic beta cell morphology	J:170198
	abnormal pancreatic beta cell physiology	J:170198
	decreased body weight	J:170198
	decreased circulating insulin level	J:170198
	decreased insulin secretion	J:170198
	hyperglycemia	J:170198
	impaired glucose tolerance	J:170198
	increased pancreatic beta cell number	J:170198
	postnatal growth retardation	J:170198
	small pancreatic islets	J:170198
Kif5b^tm1Njen/Kif5b^tm1Njen involves: 129S1/Sv	abnormal vesicle-mediated transport	J:170887
Kif5b^tm1Noh/Kif5b^tm1Noh involves: 129S4/SvJae * C57BL/6J	abnormal embryo turning	J:48447
	abnormal lysosome morphology	J:48447
	abnormal mitochondrial morphology	J:48447
	decreased embryo size	J:48447
	embryonic lethality during organogenesis, complete penetrance	J:48447

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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