Kif5b^tm1.1Njen
Targeted Allele Detail

Summary

• Symbol: Kif5b^tm1.1Njen
• Name: kinesin family member 5B; targeted mutation 1.1, Nancy A Jenkins
• MGI ID: MGI:3810072
• Synonyms: Kif5B^I, Kif5B^null, Kinesin-1B I
• Gene: Kif5b Location: Chr18:6201005-6241524 bp, - strand Genetic Position: Chr18, 4.46 cM, cytoband A2-B1
• Alliance: Kif5b^tm1.1Njen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170198
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites creating the Kif5b^tm1Njen allele. The floxed fragment was excised with a beta actin promoter-driven Cre, leaving a single loxP site. (J:170198)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kif5b Mutation: 59 strains or lines available

References

• Original: J:170198 Cui J, et al., Targeted inactivation of kinesin-1 in pancreatic beta-cells in vivo leads to insulin secretory deficiency. Diabetes. 2011 Jan;60(1):320-30
• All: 9 reference(s)