Kif5b^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif5b^tm1Noh
• Name: kinesin family member 5B; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2159694
• Synonyms: kif5B-
• Gene: Kif5b Location: Chr18:6201005-6241524 bp, - strand Genetic Position: Chr18, 4.46 cM, cytoband A2-B1
• Alliance: Kif5b^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48447
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the ATP-binding motif (P-loop) was replaced with pPGKneopA. Disruption of gene expression was verified by RT-PCR and immunoblotting. (J:48447)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif5b Mutation: 59 strains or lines available

References

• Original: J:48447 Tanaka Y, et al., Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Cell. 1998 Jun 26;93(7):1147-58
• All: 2 reference(s)