About   Help   FAQ
Chl1 Gene Detail
Summary
  • Symbol
    Chl1
  • Name
    cell adhesion molecule L1-like
  • Synonyms
    A530023M13Rik, CALL, close homolog of L1, LICAM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098266
    NCBI Gene: 12661
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:103487372-103709999 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 47.97 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098266
 protein coding gene Chr6:103487372-103727172 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031091
 protein coding gene Chr6:105620293-105868166 (+)
A/J MGP_AJ_G0031060
 protein coding gene Chr6:101604341-101845437 (+)
AKR/J MGP_AKRJ_G0030991
 protein coding gene Chr6:104387336-104626959 (+)
BALB/cJ MGP_BALBcJ_G0031071
 protein coding gene Chr6:101572109-101802224 (+)
C3H/HeJ MGP_C3HHeJ_G0030637
 protein coding gene Chr6:79739898-79981140 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031530
 protein coding gene Chr6:108318698-108571301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028694
 protein coding gene Chr6:99214472-99435549 (+)
CAST/EiJ MGP_CASTEiJ_G0030178
 protein coding gene Chr6:104690676-104930023 (+)
CBA/J MGP_CBAJ_G0030757
 protein coding gene Chr6:112534060-112756916 (+)
DBA/2J MGP_DBA2J_G0030910
 protein coding gene Chr6:100748641-100980784 (+)
FVB/NJ MGP_FVBNJ_G0030864
 protein coding gene Chr6:99864466-100087528 (+)
LP/J MGP_LPJ_G0030990
 protein coding gene Chr6:105705346-105952656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030898
 protein coding gene Chr6:116449348-116711735 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031557
 protein coding gene Chr6:104306531-104564928 (+)
PWK/PhJ MGP_PWKPhJ_G0029894
 protein coding gene Chr6:99732536-99965261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029722
 protein coding gene Chr6:103176954-103417878 (+)
WSB/EiJ MGP_WSBEiJ_G0030262
 protein coding gene Chr6:104858185-105093973 (+)



Homology
more
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
  • Synonyms
    CALL, L1CAM2
  • Links
    NCBI Gene ID: 10752
    neXtProt AC: NX_O00533
    UniProt: O00533

  • Chr Location
    3p26.3; chr3:196763-409417 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    77
  • cDNA Data
    79
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12661 NCBI Gene Model | MGI Sequence Detail 222628 C57BL/6J ±  kb
    transcript NM_007697 RefSeq | MGI Sequence Detail 7751 C57BL/6  
    polypeptide P70232 UniProt | EBI | MGI Sequence Detail 1209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 79
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2141424, MGI:2442516
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 35
      Gene Ontology 9
      Phenotypes 40
    • Earliest
      J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
    • Latest
      J:338207 Moreau MX, et al., Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons. Dev Cell. 2023 Jun 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory