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Chl1
Gene Detail
 Symbol
Name
ID
Chl1
cell adhesion molecule with homology to L1CAM
MGI:1098266
Synonyms A530023M13Rik, CALL, close homolog of L1, LICAM2
Feature Type protein coding gene
Genetic Map
Chromosome 6
47.97 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:103510876-103733035 bp, + strand
From NCBI annotation of GRCm38

  222160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Chl1

Human
homologs
Human Homolog CHL1, cell adhesion molecule L1-like
NCBI Gene ID 10752
neXtProt AC  NX_O00533
Human Synonyms  CALL, L1CAM2
Human Chr (Location)  3p26.1; chr3:196588-409417 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.
 
Interactions
Chl1 interacts with 428 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adult locomotory behavior, axon guidance, ...
Component apical part of cell, dendrite, ...
Function protease binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (78)    Tissues (53)    Images (16)
Theiler Stages: 12, 13, 18, 19, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 62
Western blot 10
RT-PCR 2
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000030077 (Evidence)
Entrez Gene12661 (Evidence)
UniGene251288
DFCITC1580155, TC1591428, TC1609863, TC1634954, TC1652011, TC1746648
DoTSDT.101187375, DT.101300318, DT.522149, DT.91384136, DT.94187408, DT.94187413, DT.94187416, DT.97389158
NIA Mouse Gene IndexU007238
Consensus CDS ProjectCCDS39582.1
International Mouse Knockout Project StatusChl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12661 NCBI Gene Model | MGI Sequence Detail 222160 C57BL/6J ±  kb
transcript NM_007697 RefSeq | MGI Sequence Detail 7751 C57BL/6 
polypeptide P70232 UniProt | EBI | MGI Sequence Detail 1209 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(1612 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR026966 Fibronectin type III C-terminal domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000005429 neural cell adhesion molecule L1-like protein
Graphical View of Protein Domain Structure
References (Earliest) J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
(Latest) J:201731 Li S, et al., Endothelial VEGF sculpts cortical cytoarchitecture. J Neurosci. 2013 Sep 11;33(37):14809-15
All references(61)
Other
accession IDs
MGI:2141424, MGI:2442516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory