Chl1
Gene Detail

Symbol Name ID

Chl1 cell adhesion molecule with homology to L1CAM MGI:1098266

Synonyms

A530023M13Rik, CALL, close homolog of L1, LICAM2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

47.97 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:103510876-103733035 bp, + strand From NCBI annotation of GRCm38   222160 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21314  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neural cell adhesion molecule-like protein
Gene Tree: Chl1

Human homologs

Human Homolog		CHL1, cell adhesion molecule with homology to L1CAM (close homolog of L1)
NCBI Gene ID		10752
neXtProt AC		NX_O00533
Human Synonyms		CALL, L1CAM2
Human Chr (Location)		3p26.1; chr3:238279-451100 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	adult locomotory behavior, axon guidance, ...
Component	apical part of cell, dendrite, ...
Function	protease binding

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (78)    Tissues (53)    Images (16)
Theiler Stages: 12, 13, 18, 19, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	62
Western blot	10
RT-PCR	2

cDNA source data(74)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000030077 (Evidence)
Entrez Gene	12661 (Evidence)
UniGene	251288
DFCI	TC1580155, TC1591428, TC1609863, TC1634954, TC1652011, TC1746648
DoTS	DT.101187375, DT.101300318, DT.522149, DT.91384136, DT.94187408, DT.94187413, DT.94187416, DT.97389158
NIA Mouse Gene Index	U007238
Consensus CDS Project	CCDS39582.1
International Mouse Knockout Project Status	Chl1

Sequences

Length	Strain/Species
genomic	12661	NCBI Gene Model | MGI Sequence Detail	222160	C57BL/6J
transcript	NM_007697	RefSeq | MGI Sequence Detail	7751	C57BL/6
polypeptide	P70232	UniProt | EBI | MGI Sequence Detail	1209	Not Applicable

All sequences(40) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1431 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR026966	Fibronectin type III C-terminal domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000005429	neural cell adhesion molecule L1-like protein

Graphical View of Protein Domain Structure

References

(Earliest) J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
(Latest) J:191011 Lee da Y, et al., Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell. 2012 Jul 10;22(1):131-8
All references(60)

Other accession IDs

MGI:2141424, MGI:2442516