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Chl1 Gene Detail
Summary
  • Symbol
    Chl1
  • Name
    cell adhesion molecule L1-like
  • Synonyms
    A530023M13Rik, CALL, close homolog of L1, LICAM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098266
    NCBI Gene: 12661
  • Gene Overview
    MyGene.info: CHL1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:103510586-103750211 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      239626 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 47.97 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALL, L1CAM2
  • Links
    NCBI Gene ID: 10752
    neXtProt AC: NX_O00533
    UniProt: O00533

  • Chr Location
    3p26.3; chr3:196588-409417 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057275 VEGA Gene Model | MGI Sequence Detail 239626 C57BL/6J ±  kb
    transcript OTTMUST00000140979 VEGA | MGI Sequence Detail 7562 Not Applicable  
    polypeptide OTTMUSP00000073743 VEGA | MGI Sequence Detail 1209 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1671 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2141424, MGI:2442516
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 21
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
    • Latest
      J:250545 Katic J, et al., The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development. J Cell Sci. 2017 Aug 01;130(15):2606-2619

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory