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Chl1 Gene Detail
Summary
  • Symbol
    Chl1
  • Name
    cell adhesion molecule L1-like
  • Synonyms
    A530023M13Rik, CALL, close homolog of L1, LICAM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098266
    NCBI Gene: 12661
Location & Maps
more
  • Sequence Map
    Chr6:103510582-103733038 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      222457 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHL1, cell adhesion molecule L1 like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CALL, L1CAM2
  • Links
    NCBI Gene ID: 10752
    neXtProt AC: NX_O00533

  • Chr Location
    3p26.1; chr3:196596-409417 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Chl1
  • Incidental Mutations
Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12661 NCBI Gene Model | MGI Sequence Detail 222457 C57BL/6J ±  kb
transcript NM_007697 RefSeq | MGI Sequence Detail 7751 C57BL/6  
polypeptide P70232 UniProt | EBI | MGI Sequence Detail 1209 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1612 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 75
    cDNA 74
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
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MGI:2141424, MGI:2442516
References
more
  • Summaries
    All 62
    Developmental Gene Expression 17
    Gene Ontology 8
    Phenotypes 25
  • Earliest
    J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
  • Latest
    J:227023 Schmalbach B, et al., Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. J Neurochem. 2015 Nov;135(4):830-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory