Gene Expression Literature Summary

• Symbol: Chl1
• Name: cell adhesion molecule L1-like
• ID: MGI:1098266

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			1			3				6	2	2		1	2			1		5
In situ RNA (section)					3	2		2		3		5		1		1	1	5		7
In situ RNA (whole mount)	1	1
Western blot				1			1		1	1			1	1			1			5
RT-PCR			1					1												2
cDNA clones								1				1							2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Chl1  cell adhesion molecule L1-like   (Synonyms: A530023M13Rik, CALL, close homolog of L1, LICAM2)
Results	Reference
3	J:317068 Alsanie WF, Penna V, Schachner M, Thompson LH, Parish CL, Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Sci Rep. 2017 Aug 24;7(1):9368
1	J:220736 Bye CR, Jonsson ME, Bjorklund A, Parish CL, Thompson LH, Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
1	J:279156 Bye CR, Rytova V, Alsanie WF, Parish CL, Thompson LH, Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins. J Neurosci. 2019 Aug 21;39(34):6656-6667
1*	J:158222 Demyanenko GP, Halberstadt AI, Rao RS, Maness PF, CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons. Neuroscience. 2010 Jan 13;165(1):107-15
4	J:96525 Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J, Maness PF, Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron. 2004 Oct 28;44(3):423-37
1	J:171029 Demyanenko GP, Siesser PF, Wright AG, Brennaman LH, Bartsch U, Schachner M, Maness PF, L1 and CHL1 Cooperate in Thalamocortical Axon Targeting. Cereb Cortex. 2011 Feb;21(2):401-12
3	J:162273 Faux C, Rakic S, Andrews W, Yanagawa Y, Obata K, Parnavelas JG, Differential gene expression in migrating cortical interneurons during mouse forebrain development. J Comp Neurol. 2010 Apr 15;518(8):1232-48
4*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
6*	J:55994 Hillenbrand R, Molthagen M, Montag D, Schachner M, The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions. Eur J Neurosci. 1999 Mar;11(3):813-26
1	J:171301 Huang X, Zhu LL, Zhao T, Wu LY, Wu KW, Schachner M, Xiao ZC, Fan M, CHL1 negatively regulates the proliferation and neuronal differentiation of neural progenitor cells through activation of the ERK1/2 MAPK pathway. Mol Cell Neurosci. 2011 Jan;46(1):296-307
1*	J:154369 Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE, Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Dev Dyn. 2009 Oct 29;238(12):3065-3079
2	J:191011 Lee da Y, Gianino SM, Gutmann DH, Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell. 2012 Jul 10;22(1):131-8
2	J:201731 Li S, Haigh K, Haigh JJ, Vasudevan A, Endothelial VEGF sculpts cortical cytoarchitecture. J Neurosci. 2013 Sep 11;33(37):14809-15
2	J:320190 Liu T, Wan RP, Tang LJ, Liu SJ, Li HJ, Zhao QH, Liao WP, Sun XF, Yi YH, Long YS, A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Mol Neurobiol. 2015;51(3):1053-63
1	J:288353 Lutz D, Sharaf A, Drexler D, Kataria H, Wolters-Eisfeld G, Brunne B, Kleene R, Loers G, Frotscher M, Schachner M, Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development. Sci Rep. 2017 Nov 10;7(1):15268
1	J:335166 Maejima I, Hara T, Tsukamoto S, Koizumi H, Kawauchi T, Akuzawa T, Hirai R, Kobayashi H, Isobe I, Emoto K, Kosako H, Sato K, RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution. Commun Biol. 2023 Apr 21;6(1):440
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:306314 Maheshwari U, Kraus D, Vilain N, Holwerda SJB, Cankovic V, Maiorano NA, Kohler H, Satoh D, Sigrist M, Arber S, Kratochwil CF, Di Meglio T, Ducret S, Rijli FM, Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets. Cell Rep. 2020 Jun 16;31(11):107767
1	J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
2*	J:308818 Moreau MX, Saillour Y, Cwetsch AW, Pierani A, Causeret F, Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Development. 2021 Jul 15;148(14):dev197962
2	J:338207 Moreau MX, Saillour Y, Elorriaga V, Bouloudi B, Delberghe E, Deutsch Guerrero T, Ochandorena-Saa A, Maeso-Alonso L, Marques MM, Marin MC, Spassky N, Pierani A, Causeret F, Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons. Dev Cell. 2023 Jun 7;
1	J:213066 Namba T, Kibe Y, Funahashi Y, Nakamuta S, Takano T, Ueno T, Shimada A, Kozawa S, Okamoto M, Shimoda Y, Oda K, Wada Y, Masuda T, Sakakibara A, Igarashi M, Miyata T, Faivre-Sarrailh C, Takeuchi K, Kaibuchi K, Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron. 2014 Feb 19;81(4):814-29
2*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
1*	J:235949 Ren J, Zhao T, Xu Y, Ye H, Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. Brain Res. 2016 Oct 1;1648(Pt A):290-7
1	J:325971 Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N, Regulation of prefrontal patterning and connectivity by retinoic acid. Nature. 2021 Oct;598(7881):483-488
2	J:234018 Singh S, Howell D, Trivedi N, Kessler K, Ong T, Rosmaninho P, Raposo AA, Robinson G, Roussel MF, Castro DS, Solecki DJ, Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. Elife. 2016;5:e12717
2*	J:143778 Tamplin OJ, Cox BJ, Rossant J, Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol. 2011 Dec 15;360(2):415-25
3	J:277380 Telley L, Agirman G, Prados J, Amberg N, Fievre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D, Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440)
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
2	J:240378 Van Battum EY, Gunput RA, Lemstra S, Groen EJ, Yu KL, Adolfs Y, Zhou Y, Hoogenraad CC, Yoshida Y, Schachner M, Akhmanova A, Pasterkamp RJ, The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections. Nat Commun. 2014 Jul 10;5:4317
4*	J:302618 Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M, The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811
2	J:122943 Williams SE, Grumet M, Colman DR, Henkemeyer M, Mason CA, Sakurai T, A role for Nr-CAM in the patterning of binocular visual pathways. Neuron. 2006 May 18;50(4):535-47
5	J:130566 Wright AG, Demyanenko GP, Powell A, Schachner M, Enriquez-Barreto L, Tran TS, Polleux F, Maness PF, Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon. J Neurosci. 2007 Dec 12;27(50):13667-79
1	J:130375 Ye H, Tan YL, Ponniah S, Takeda Y, Wang SQ, Schachner M, Watanabe K, Pallen CJ, Xiao ZC, Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. EMBO J. 2008 Jan 9;27(1):188-200