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Cast Gene Detail
Summary
  • Symbol
    Cast
  • Name
    calpastatin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098236
    NCBI Gene: 12380
  • Gene Overview
    MyGene.info: CAST
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74692368-74808810 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.52 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    751 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098236
protein coding gene Chr13:74692366-74808874 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020769
protein coding gene Chr13:75225897-75333373 (-)
A/J MGP_AJ_G0020725
protein coding gene Chr13:72619410-72729358 (-)
AKR/J MGP_AKRJ_G0020698
protein coding gene Chr13:74838549-74958110 (-)
BALB/cJ MGP_BALBcJ_G0020721
protein coding gene Chr13:73099171-73208460 (-)
C3H/HeJ MGP_C3HHeJ_G0020515
protein coding gene Chr13:74533136-74643557 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021158
protein coding gene Chr13:77748675-77865395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018726
protein coding gene Chr13:69513848-69623148 (-)
CAST/EiJ MGP_CASTEiJ_G0020033
protein coding gene Chr13:73632233-73750103 (-)
CBA/J MGP_CBAJ_G0020474
protein coding gene Chr13:80664111-80796209 (-)
DBA/2J MGP_DBA2J_G0020599
protein coding gene Chr13:72367553-72477809 (-)
FVB/NJ MGP_FVBNJ_G0020579
protein coding gene Chr13:71409768-71521471 (-)
LP/J MGP_LPJ_G0020672
protein coding gene Chr13:75474491-75589883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020608
protein coding gene Chr13:79047015-79170408 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021198
protein coding gene Chr13:74163934-74276889 (-)
PWK/PhJ MGP_PWKPhJ_G0019786
protein coding gene Chr13:71246698-71357424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019609
protein coding gene Chr13:70541041-70655122 (-)
WSB/EiJ MGP_WSBEiJ_G0020090
protein coding gene Chr13:74675500-74794589 (-)



Homology
more
  • Human Ortholog
    CAST, calpastatin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CAST, calpastatin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BS-17, PLACK
  • Links
    NCBI Gene ID: 831
    neXtProt AC: NX_P20810
    UniProt: P20810

  • Chr Location
    5q15; chr5:96662037-96774683 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit augmented DNA fragmentation in CA1 pyramidal neurons following excitotoxic kainate treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021585 Ensembl Gene Model | MGI Sequence Detail 116443 C57BL/6J ±  kb
    transcript ENSMUST00000223206 Ensembl | MGI Sequence Detail 5141 Not Applicable  
    polypeptide ENSMUSP00000152174 Ensembl | MGI Sequence Detail 788 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR026998 Calpastatin
      IPR001259 Proteinase inhibitor I27, calpastatin
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 41
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory