Wrn
Gene Detail

Symbol Name ID

Wrn Werner syndrome homolog (human) MGI:109635

Feature Type

protein coding gene

Genetic Map

Chromosome 8

20.30 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr8:33234384-33385527 bp, - strand From Ensembl annotation of GRCm38   151144 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wrn

Human homologs

Human Homolog		WRN, Werner syndrome, RecQ helicase-like
NCBI Gene ID		7486
neXtProt AC		NX_Q14191
Human Synonyms		RECQ3, RECQL2, RECQL3
Human Chr (Location)		8p12; chr8:30890778-31031277 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WRN

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.

 
Human Diseases Modeled Using Mouse Wrn (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	ATP catabolic process, base-excision repair, ...
Component	centrosome, intracellular, ...
Function	3'-5' DNA helicase activity, 3'-5' exonuclease activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (4)    Images (2)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	2
Northern blot	3
RT-PCR	3

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(3) cDNA(44) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000031583 (Evidence)
Entrez Gene	22427 (Evidence)
UniGene	228805
DFCI	TC1582376, TC1589639, TC1601419
DoTS	DT.101365350, DT.102556440, DT.103558334, DT.110889416, DT.110889465, DT.40166722, DT.87025060, DT.97343342
NIA Mouse Gene Index	U029710
EC	3.1.-.-, 3.6.4.12
PDB	2E6L, 2E6M
Consensus CDS Project	CCDS22229.1
International Mouse Knockout Project Status	Wrn

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031583	Ensembl Gene Model | MGI Sequence Detail	151144	C57BL/6J
transcript	ENSMUST00000033991	Ensembl | MGI Sequence Detail	6262	Not Applicable
polypeptide	ENSMUSP00000033991	Ensembl | MGI Sequence Detail	1401	Not Applicable

All sequences(48) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(800 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002562	3'-5' exonuclease domain
InterPro	IPR004589	DNA helicase, ATP-dependent, RecQ type
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR002121	Helicase/RNase D C-terminal, HRDC domain
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR010997	HRDC-like
InterPro	IPR012337	Ribonuclease H-like domain
InterPro	IPR018982	RQC domain
Protein Ontology	PR:000017455	werner syndrome ATP-dependent helicase

References

(Earliest) J:46871 Yu CE, et al., Positional cloning of the Werner's syndrome gene [see comments]. Science. 1996 Apr 12;272(5259):258-62
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(55)

Other accession IDs

MGD-MRK-39634, MGI:2142626