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Wrn Gene Detail
Summary
  • Symbol
    Wrn
  • Name
    Werner syndrome RecQ like helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109635
    NCBI Gene: 22427
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:33235682-33385508 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      149827 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.30 cM, cytoband A4
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    WRN, Werner syndrome RecQ like helicase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WRN, Werner syndrome RecQ like helicase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RECQ3, RECQL2, RECQL3
  • Links
    NCBI Gene ID: 7486
    neXtProt AC: NX_Q14191
    UniProt: Q14191

  • Chr Location
    8p12; chr8:31033262-31173761 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6659
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WRN
  • Gene Tree
    Wrn
Human Diseases
more
  • Diseases
    1 with Wrn mouse models; 1 with human WRN associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 6 genetic backgrounds
    42 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060957 VEGA Gene Model | MGI Sequence Detail 149827 C57BL/6J ±  kb
    transcript OTTMUST00000148966 VEGA | MGI Sequence Detail 5019 Not Applicable  
    polypeptide OTTMUSP00000077360 VEGA | MGI Sequence Detail 1401 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1660 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 3
      cDNA 44
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39634, MGI:2142626
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 16
      Phenotypes 25
    • Earliest
      J:46871 Yu CE, et al., Positional cloning of the Werner's syndrome gene [see comments]. Science. 1996 Apr 12;272(5259):258-62
    • Latest
      J:243692 Aumailley L, et al., Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice. PLoS One. 2015;10(10):e0140292

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory