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Wrn
Gene Detail
Symbol

Name
ID
Wrn
Werner syndrome homolog (human)
MGI:109635
Feature Type
protein coding gene
Genetic Map
Chromosome 8
20.30 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:33234384-33385527 bp, - strand
From Ensembl annotation of GRCm38

  151144 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Wrn

Human
homologs
Human Homolog WRN, Werner syndrome, RecQ helicase-like
NCBI Gene ID 7486
neXtProt AC  NX_Q14191
Human Synonyms  RECQ3, RECQL2, RECQL3
Human Chr (Location)  8p12; chr8:31033262-31173761 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human WRN
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.
 
Human Diseases Modeled Using Mouse Wrn (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Wrn interacts with 303 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process ATP catabolic process, base-excision repair, ...
Component centrosome, intracellular, ...
Function 3'-5' DNA helicase activity, 3'-5' exonuclease activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (4)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 3
RT-PCR 3
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(3) cDNA(44) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031583 (Evidence)
Entrez Gene22427 (Evidence)
UniGene228805
DFCITC1582376, TC1589639, TC1601419
DoTSDT.101365350, DT.102556440, DT.103558334, DT.110889416, DT.110889465, DT.40166722, DT.87025060, DT.97343342
NIA Mouse Gene IndexU029710
EC3.1.-.-, 3.6.4.12
PDB2E6L, 2E6M
Consensus CDS ProjectCCDS22229.1
International Mouse Knockout Project StatusWrn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031583 Ensembl Gene Model | MGI Sequence Detail 151144 C57BL/6J ±  kb
transcript ENSMUST00000033991 Ensembl | MGI Sequence Detail 6262 Not Applicable 
polypeptide ENSMUSP00000033991 Ensembl | MGI Sequence Detail 1401 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(1741 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002562 3'-5' exonuclease domain
InterPro IPR004589 DNA helicase, ATP-dependent, RecQ type
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR002121 HRDC domain
InterPro IPR010997 HRDC-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR018982 RQC domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000017455 werner syndrome ATP-dependent helicase
References
(Earliest) J:46871 Yu CE, et al., Positional cloning of the Werner's syndrome gene [see comments]. Science. 1996 Apr 12;272(5259):258-62
(Latest) J:213181 Brennan TA, et al., Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis. Dis Model Mech. 2014 May;7(5):583-92
All references(59)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39634, MGI:2142626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory