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Ackr3
Gene Detail
Symbol

Name
ID
Ackr3
atypical chemokine receptor 3
MGI:109562
Synonyms
Cmkor1, Cxcr7, Rdc1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
45.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:90203980-90216751 bp, + strand
From VEGA annotation of GRCm38

  12772 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ackr3

Human
homologs
Human Homolog ACKR3, atypical chemokine receptor 3
NCBI Gene ID 57007
neXtProt AC  NX_P25106
Human Synonyms  CMKOR1, CXCR7, CXC-R7, CXCR-7, GPR159, RDC1, RDC-1
Human Chr (Location)  2q37.3; chr2:236560781-236582358 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(8) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous null mutations result in perinatal lethality with cardiac defects including semilunar valve defects.
 
Phenotype Images(3)
Interactions
Ackr3 interacts with 218 markers (Mir15a, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, cell adhesion, ...
Component cell surface, coated pit, ...
Function chemokine receptor activity, coreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (325)    Tissues (103)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 303
Northern blot 14
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029162 (Evidence)
Ensembl Gene ModelENSMUSG00000044337 (Evidence)
Entrez Gene12778 (Evidence)
DFCITC1582433, TC1582972
DoTSDT.529260
Consensus CDS ProjectCCDS15152.1
International Mouse Knockout Project StatusAckr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029162 VEGA Gene Model | MGI Sequence Detail 12772 C57BL/6J ±  kb
transcript OTTMUST00000072324 VEGA | MGI Sequence Detail 3065 Not Applicable 
polypeptide OTTMUSP00000037197 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001416 CXC chemokine receptor 7
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001211 C-X-C chemokine receptor type 7
References
(Earliest) J:47562 Heesen M, et al., Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics. 1998 Apr;47(5):364-70
(Latest) J:213419 Abe P, et al., CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development. 2014 May;141(9):1857-63
All references(61)
Other
accession IDs
MGD-MRK-39561, MGI:2138598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory