Cxcr7
Gene Detail

Symbol Name ID

Cxcr7 chemokine (C-X-C motif) receptor 7 MGI:109562

Synonyms

Cmkor1, Rdc1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

45.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:90203980-90216751 bp, + strand From VEGA annotation of GRCm38   12772 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr7

Human homologs

Human Homolog		CXCR7, chemokine (C-X-C motif) receptor 7
NCBI Gene ID		57007
neXtProt AC		NX_P25106
Human Synonyms		CMKOR1, CXC-R7, CXCR-7, GPR159, RDC1, RDC-1
Human Chr (Location)		2q37.3; chr2:237478380-237490997 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(10) Gene trapped(8)
 

Most homozygous null mutations result in perinatal lethality with cardiac defects including semilunar valve defects.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	angiogenesis, cell adhesion, ...
Component	cytoplasm, endosome, ...
Function	chemokine binding, coreceptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (303)    Tissues (88)    Images (41)
Theiler Stages: 14, 16, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	281
Northern blot	14

cDNA source data(42)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(42) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029162 (Evidence)
Ensembl Gene Model	ENSMUSG00000044337 (Evidence)
Entrez Gene	12778 (Evidence)
UniGene	6522
DFCI	TC1582433, TC1582972
DoTS	DT.529260
Consensus CDS Project	CCDS15152.1
International Mouse Knockout Project Status	Cxcr7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029162	VEGA Gene Model | MGI Sequence Detail	12772	C57BL/6J
transcript	OTTMUST00000072324	VEGA | MGI Sequence Detail	3065	Not Applicable
polypeptide	OTTMUSP00000037197	VEGA | MGI Sequence Detail	362	Not Applicable

All sequences(25) RefSeq(4) UniProt(1)

Polymorphisms

PCR(1) : SNPs(122 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001416	RDC1 orphan receptor
Protein Ontology	PR:000001211	chemokine receptor CXCR7

References

(Earliest) J:47562 Heesen M, et al., Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics. 1998 Apr;47(5):364-70
(Latest) J:194642 Zhu B, et al., CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012 Nov;30(11):2571-83
All references(55)

Other accession IDs

MGD-MRK-39561, MGI:2138598