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Ackr3 Gene Detail
Summary
  • Symbol
    Ackr3
  • Name
    atypical chemokine receptor 3
  • Synonyms
    Cmkor1, Cxcr7, Rdc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109562
    NCBI Gene: 12778
  • Gene Overview
    MyGene.info: ACKR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:90203980-90216751 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12772 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 45.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ACKR3, atypical chemokine receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACKR3, atypical chemokine receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMKOR1, CXCR7, CXC-R7, CXCR-7, GPR159, RDC1, RDC-1
  • Links
    NCBI Gene ID: 57007
    neXtProt AC: NX_P25106
    UniProt: P25106

  • Chr Location
    2q37.3; chr2:236537131-236582358 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 9 alleles in 9 genetic backgrounds
    3 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most homozygous null mutations result in perinatal lethality with cardiac defects including semilunar valve defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029162 VEGA Gene Model | MGI Sequence Detail 12772 C57BL/6J ±  kb
    transcript OTTMUST00000072324 VEGA | MGI Sequence Detail 3065 Not Applicable  
    polypeptide OTTMUSP00000037197 VEGA | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      146 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39561, MGI:2138598
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 34
      Gene Ontology 5
      Phenotypes 32
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:263890 Kaur G, et al., Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface. PLoS One. 2018;13(7):e0200211

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory