About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ackr3
atypical chemokine receptor 3
MGI:109562
58 phenotypes from 9 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Ackr3tm1.1Fma/Ackr3+
involves: BALB/cJ * C57BL/6
abnormal aortic valve cusp morphology J:124878
thick aortic valve cusps J:124878
Ackr3tm1.1Fma/Ackr3tm1.1Fma
involves: BALB/cJ * C57BL/6
abnormal aortic valve cusp morphology J:124878
abnormal atrioventricular cushion morphology J:124878
abnormal cardiac outflow tract development J:124878
abnormal pulmonary valve cusp morphology J:124878
atrial septal defect J:124878
bicuspid aortic valve J:124878
bicuspid pulmonary valve J:124878
calcified aortic valve J:124878
decreased marginal zone B cell number J:124878
normal digestive/alimentary phenotype J:124878
dilated heart right ventricle J:124878
neonatal lethality, incomplete penetrance J:124878
normal nervous system phenotype J:124878
overriding aortic valve J:124878
premature death J:124878
thick aortic valve cusps J:124878
thick pulmonary valve cusps J:124878
unicuspid aortic valve J:124878
unicuspid pulmonary valve J:124878
ventricular septal defect J:124878
Ackr3tm1.1Rodb/Ackr3tm1.1Rodb
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
normal hematopoietic system phenotype J:165184
normal immune system phenotype J:165184
Ackr3tm1.1Twb/Ackr3tm1.1Twb
involves: 129S/SvEv * BALB/cJ * C57BL/6
abnormal atrioventricular cushion morphology J:167833
abnormal cardiovascular system physiology J:167833
abnormal heart and great artery attachment J:167833
abnormal semilunar valve morphology J:167833
aortic valve stenosis J:167833
cyanosis J:167833
dilated heart atrium J:167833
enlarged heart J:167833
hemorrhage J:167833
neonatal lethality, complete penetrance J:167833
overriding aortic valve J:167833
perimembraneous ventricular septal defect J:167833
perinatal lethality, incomplete penetrance J:167833
pulmonary valve stenosis J:167833
respiratory distress J:167833
thick aortic valve J:167833
thick pulmonary valve J:167833
Ackr3tm1Fma/Ackr3tm1Fma
Tg(Tek-cre)12Flv/?
involves: C3H * C57BL/6
abnormal aortic valve cusp morphology J:124878
abnormal pulmonary valve cusp morphology J:124878
bicuspid aortic valve J:124878
bicuspid pulmonary valve J:124878
dilated heart right ventricle J:124878
thick aortic valve cusps J:124878
thick pulmonary valve cusps J:124878
unicuspid aortic valve J:124878
unicuspid pulmonary valve J:124878
Ackr3tm1Jgo/Ackr3+
involves: 129S/SvEvBrd * C57BL/6
cardiac fibrosis J:136246
lung inflammation J:136246
myocardial fiber degeneration J:136246
pulmonary fibrosis J:136246
Ackr3tm1Jgo/Ackr3tm1Jgo
involves: 129S/SvEvBrd * C57BL/6
abnormal atrial thrombosis J:136246
cardiac fibrosis J:136246
decreased survivor rate J:136246
heart hyperplasia J:136246
lung inflammation J:136246
myocardial fiber degeneration J:136246
postnatal lethality, incomplete penetrance J:136246
pulmonary fibrosis J:136246
Ackr3tm1Litt/Ackr3tm1Litt
involves: C57BL/6 * FVB/N
abnormal interventricular septum morphology J:156990
abnormal semilunar valve morphology J:156990
perinatal lethality, complete penetrance J:156990
Ackr3tm1Twb/Ackr3tm1.1Twb
Tg(Tek-cre)12Flv/0
involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
abnormal myocardial fiber morphology J:167833
cardiac fibrosis J:167833
cardiac hypertrophy J:167833
heart left ventricle hypertrophy J:167833
increased myocardial fiber size J:167833
myocardial fiber disarray J:167833
thick aortic valve J:167833
thick pulmonary valve J:167833
Ackr3tm1Yzo/Ackr3tm1Yzo
Not Specified
abnormal blood vessel morphology J:195048
normal nervous system phenotype J:195048
Ackr3tm2b(EUCOMM)Wtsi/Ackr3+
C57BL/6N-Ackr3tm2b(EUCOMM)Wtsi/Ics
decreased grip strength J:211773
decreased total retina thickness J:211773
increased mean corpuscular hemoglobin concentration J:211773
tremors J:211773
Ackr3tm2b(EUCOMM)Wtsi/Ackr3tm2b(EUCOMM)Wtsi
C57BL/6N-Ackr3tm2b(EUCOMM)Wtsi/Ics
preweaning lethality, complete penetrance J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory