Gene Expression Literature Summary

• Symbol: Ackr3
• Name: atypical chemokine receptor 3
• ID: MGI:109562

50 matching records from 50 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1		1				1	1	1	1									1	1	2	5
In situ RNA (section)		1		5		6		11		10		14		10	1	3		2		4	4	5
In situ RNA (whole mount)				3						1		1
In situ reporter (knock in)						1		2		2	1	1		1		2						1
Northern blot					1				1		1		1				1					1
Western blot																			1			1
RT-PCR						1		1		1	1	3		1		2				1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ackr3  atypical chemokine receptor 3   (Synonyms: Cmkor1, Cxcr7, Rdc1)
Results	Reference
4	J:226478 Abe P, Molnar Z, Tzeng YS, Lai DM, Arnold SJ, Stumm R, Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling. J Neurosci. 2015 Sep 23;35(38):13053-63
1*	J:213419 Abe P, Mueller W, Schutz D, MacKay F, Thelen M, Zhang P, Stumm R, CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development. 2014 May;141(9):1857-63
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
1	J:226941 Akerberg BN, Sarangam ML, Stankunas K, Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease. Dev Biol. 2015 Nov 1;407(1):158-72
1	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4*	J:165184 Berahovich RD, Zabel BA, Penfold ME, Lewen S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ, CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010 Nov 1;185(9):5130-9
4	J:208337 Bodea GO, Spille JH, Abe P, Andersson AS, Acker-Palmer A, Stumm R, Kubitscheck U, Blaess S, Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development. 2014 Feb;141(3):661-73
6*	J:124566 Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ, A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. 2006 Sep 4;203(9):2201-13
1*	J:331053 Chandrasekaran P, Negretti NM, Sivakumar A, Liberti DC, Wen H, Peers de Nieuwburgh M, Wang JY, Michki NS, Chaudhry FN, Kaur S, Lu M, Jin A, Zepp JA, Young LR, Sucre JMS, Frank DB, CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth. Development. 2022 Nov 1;149(21):dev200909
1	J:153556 Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, Broccoli V, Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity. Dev Biol. 2009 Oct 1;334(1):59-71
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
9	J:345878 Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ, Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring. Development. 2024 Feb 15;151(4)
5	J:333567 Gonzalez-Meljem JM, Ivins S, Andoniadou CL, Le Tissier P, Scambler P, Martinez-Barbera JP, An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development. PLoS One. 2023;18(2):e0280001
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:189818 Haege S, Einer C, Thiele S, Mueller W, Nietzsche S, Lupp A, Mackay F, Schulz S, Stumm R, CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. PLoS One. 2012;7(8):e42814
1	J:156021 Hick AC, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, Nagasawa T, Vanderhaeghen P, Courtoy PJ, Rousseau GG, Lemaigre FP, Pierreux CE, Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev Biol. 2009;9:66
4	J:192400 Hunger C, Odemis V, Engele J, Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration. Exp Cell Res. 2012 Oct 15;318(17):2178-90
2	J:263890 Kaur G, Helmer RA, Smith LA, Martinez-Zaguilan R, Dufour JM, Chilton BS, Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface. PLoS One. 2018;13(7):e0200211
5	J:214795 Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM, Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
1	J:290226 Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO, Delineating the early transcriptional specification of the mammalian trachea and esophagus. Elife. 2020 Jun 9;9:e55526
3	J:344967 Le VH, Orniacki C, Murcia-Belmonte V, Denti L, Schutz D, Stumm R, Ruhrberg C, Erskine L, CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm. Development. 2024 Jan 15;151(2)
2	J:185240 Lefebvre S, Fliniaux I, Schneider P, Mikkola ML, Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012 Apr;132(4):1094-102
2	J:293452 Liu Z, Zhang Z, Lindtner S, Li Z, Xu Z, Wei S, Liang Q, Wen Y, Tao G, You Y, Chen B, Wang Y, Rubenstein JL, Yang Z, Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development. Cereb Cortex. 2019 Jun 1;29(6):2653-2667
1*	J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
1*	J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:197761 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL, Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98
4	J:204198 Memi F, Abe P, Cariboni A, MacKay F, Parnavelas JG, Stumm R, CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. J Neurosci. 2013 Oct 30;33(44):17527-37
1	J:199453 Mithal DS, Ren D, Miller RJ, CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development. Glia. 2013 Aug;61(8):1288-305
1	J:288455 Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR, Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep. 2019 Jan 29;26(5):1157-1173.e5
1	J:89729 Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF, Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003 May 15;423(6937):302-5
1	J:171448 Probst S, Kraemer C, Demougin P, Sheth R, Martin GR, Shiratori H, Hamada H, Iber D, Zeller R, Zuniga A, SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011 May;138(10):1913-23
1*	J:177918 Quille ML, Carat S, Quemener-Redon S, Hirchaud E, Baron D, Benech C, Guihot J, Placet M, Mignen O, Ferec C, Houlgatte R, Friocourt G, High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS One. 2011;6(9):e25181
5	J:275611 Saaber F, Schutz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R, ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not beta-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9
3	J:283877 Sanchez-Alcaniz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, Lopez-Bendito G, Stumm R, Marin O, Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90
7	J:124878 Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martinez-A C, Mackay CR, Mackay F, Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
1	J:164624 Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y, The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol. 2009 Aug;20(8):1714-23
6*	J:272319 Tiveron MC, Boutin C, Daou P, Moepps B, Cremer H, Expression and function of CXCR7 in the mouse forebrain. J Neuroimmunol. 2010;224(1-2):72-9
4*	J:235634 Trousse F, Poluch S, Pierani A, Dutriaux A, Bock HH, Nagasawa T, Verdier JM, Rossel M, CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells. Cereb Cortex. 2015 Oct;25(10):3446-57
2	J:327277 Venkataramanappa S, Saaber F, Abe P, Schutz D, Kumar PA, Stumm R, Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers. Cell Rep. 2022 Aug 2;40(5):111157
2	J:159849 Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL, Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14;30(15):5334-45
4	J:223711 Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL, CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron. 2011 Jan 13;69(1):61-76
2	J:286078 Whitman MC, Miyake N, Nguyen EH, Bell JL, Matos Ruiz PM, Chan WM, Di Gioia SA, Mukherjee N, Barry BJ, Bosley TM, Khan AO, Engle EC, Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans. Hum Mol Genet. 2019 Sep 15;28(18):3113-3125
1	J:264478 Wu PR, Cho KKA, Vogt D, Sohal VS, Rubenstein JLR, The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex. 2017 Sep 1;27(9):4303-4313
1	J:239270 Yang Y, Shen W, Ni Y, Su Y, Yang Z, Zhao C, Impaired Interneuron Development after Foxg1 Disruption. Cereb Cortex. 2017 Jan 1;27(1):793-808
3*	J:167833 Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D, The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011 Feb;240(2):384-93
1	J:304122 Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H, Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 Jul 17;9(7):1714
2	J:294199 Zhu Y, Hirata T, Mackay F, Murakami F, Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation. Sci Rep. 2020 Jul 16;10(1):11830
4	J:222550 Zhu Y, Matsumoto T, Nagasawa T, Mackay F, Murakami F, Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells. J Neurosci. 2015 Jun 17;35(24):9211-24