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Ackr5 Gene Detail
Summary
  • Symbol
    Ackr5
  • Name
    atypical chemokine receptor 5
  • Synonyms
    Admr, AM-R, G10-D, Gpcr17, Gpcr22, Gpr182, NOW
  • Feature Type
    protein coding gene
  • IDs
    MGI:109545
    NCBI Gene: 11536
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127585471-127587667 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 75.07 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109545
 protein coding gene Chr10:127583145-127587667 (-)
129S1/SvImJ ENSMUSG00200013294
 protein coding gene Chr10:123936252-123940709 (-)
A/J ENSMUSG00195013126
 protein coding gene Chr10:124399370-124403823 (-)
AKR/J ENSMUSG00220004936
 protein coding gene Chr10:124004928-124009384 (-)
BALB/cJ ENSMUSG00180009061
 protein coding gene Chr10:124390403-124394855 (-)
C3H/HeJ ENSMUSG00175005629
 protein coding gene Chr10:124389510-124393968 (-)
C57BL/6NJ ENSMUSG00215005978
 protein coding gene Chr10:124001476-124005934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015908
 protein coding gene Chr10:120101617-120106013 (-)
CAST/EiJ ENSTCUG00005035701
 protein coding gene Chr10:123373380-123377837 (-)
CBA/J ENSMUSG00210008399
 protein coding gene Chr10:124213719-124218177 (-)
DBA/2J ENSMUSG00185026097
 protein coding gene Chr10:124368854-124373304 (-)
FVB/NJ ENSMUSG00205012891
 protein coding gene Chr10:123610302-123614756 (-)
JF1/MsJ ENSUMUG00000042178
 protein coding gene Chr10:125663091-125667503 (-)
LP/J ENSMUSG00230030025
 protein coding gene Chr10:126283927-126288378 (-)
NOD/ShiLtJ ENSMUSG00190013376
 protein coding gene Chr10:124432469-124436925 (-)
NZO/HlLtJ ENSMUSG00225036313
 protein coding gene Chr10:130492786-130497237 (-)
PWK/PhJ ENSLUMG00010009415
 protein coding gene Chr10:124123855-124128296 (-)
SPRET/EiJ ENSMSPG00010027461
 protein coding gene Chr10:126076928-126079482 (-)
WSB/EiJ ENSIUOG00005008816
 protein coding gene Chr10:124000408-124004837 (-)



Homology
more
  • Human Ortholog
    ACKR5, atypical chemokine receptor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACKR5, atypical chemokine receptor 5
  • Synonyms
    7TMR, ADMR, AM-R, AMR, G10D, gamrh, GPR182, hrhAMR, L1-R
  • Links
    NCBI Gene ID: 11318
    UniProt: O15218

  • Chr Location
    12q13.3; chr12:56994492-56998889 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    60
  • cDNA Data
    8
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11536 NCBI Gene Model | MGI Sequence Detail 2197 C57BL/6J ±  kb
    transcript NM_007412 RefSeq | MGI Sequence Detail 1694 C57BL/6  
    polypeptide P43142 UniProt | EBI | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16346, MGD-MRK-18602, MGD-MRK-39544, MGI:8351750, MGI:99566
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory