Slc2a2
Gene Detail

Symbol Name ID

Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 MGI:1095438

STS

D3Nds12

Synonyms

Glut2, Glut-2, liver-type glucose transporter

Feature Type

protein coding gene

Genetic Map

Chromosome 3

12.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:28697903-28728356 bp, + strand From VEGA annotation of GRCm38   30454 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc2a2

Human homologs

Human Homolog		SLC2A2, solute carrier family 2 (facilitated glucose transporter), member 2
NCBI Gene ID		6514
neXtProt AC		NX_P11168
Human Synonyms		GLUT2
Human Chr (Location)		3q26.1-q26.2; chr3:170714137-170744768 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC2A2

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.

 
Human Diseases Modeled Using Mouse Slc2a2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	carbohydrate transport, carbohydrate utilization, ...
Component	basolateral plasma membrane, brush border, ...
Function	dehydroascorbic acid transporter activity, D-glucose transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (50)    Tissues (17)    Images (30)
Theiler Stages: 11, 12, 13, 15, 17, 20, 22, 23, 24, 26

Assay Type	Results
Immunohistochemistry	3
RNA in situ	35
Northern blot	7
RT-PCR	5

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(1) cDNA(51) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035916 (Evidence)
Ensembl Gene Model	ENSMUSG00000027690 (Evidence)
Entrez Gene	20526 (Evidence)
UniGene	18443
DFCI	TC1580021
DoTS	DT.101221863, DT.111047157, DT.490066
NIA Mouse Gene Index	U003100
Consensus CDS Project	CCDS50880.1
International Mouse Knockout Project Status	Slc2a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035916	VEGA Gene Model | MGI Sequence Detail	30454	C57BL/6J
transcript	OTTMUST00000092113	VEGA | MGI Sequence Detail	2566	Not Applicable
polypeptide	OTTMUSP00000050835	VEGA | MGI Sequence Detail	523	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(223 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR002440	Glucose transporter, type 2 (GLUT2)
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR003663	Sugar/inositol transporter
InterPro	IPR005829	Sugar transporter, conserved site
Protein Ontology	PR:000015064	solute carrier family 2, facilitated glucose transporter member 2

References

(Earliest) J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(145)

Other accession IDs

MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756