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Slc2a2 Gene Detail
Summary
  • Symbol
    Slc2a2
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 2
  • Synonyms
    Glut2, Glut-2, liver-type glucose transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095438
    NCBI Gene: 20526
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:28697903-28728361 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 12.19 cM
  • Mapping Data
    6 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095438
protein coding gene Chr3:28697903-28731359 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027116
protein coding gene Chr3:26092755-26127290 (+)
A/J MGP_AJ_G0027076
protein coding gene Chr3:25817973-25852122 (+)
AKR/J MGP_AKRJ_G0027045
protein coding gene Chr3:26198136-26236662 (+)
BALB/cJ MGP_BALBcJ_G0027088
protein coding gene Chr3:25523731-25556776 (+)
C3H/HeJ MGP_C3HHeJ_G0026829
protein coding gene Chr3:26237679-26270567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027533
protein coding gene Chr3:27478156-27511659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024895
protein coding gene Chr3:23834632-23869018 (+)
CAST/EiJ MGP_CASTEiJ_G0026284
protein coding gene Chr3:26086791-26123320 (+)
CBA/J MGP_CBAJ_G0026807
protein coding gene Chr3:28222258-28263998 (+)
DBA/2J MGP_DBA2J_G0026941
protein coding gene Chr3:25398993-25432160 (+)
FVB/NJ MGP_FVBNJ_G0026909
protein coding gene Chr3:24856963-24889920 (+)
LP/J MGP_LPJ_G0027053
protein coding gene Chr3:26785262-26819165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026930
protein coding gene Chr3:30770491-30807243 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027593
protein coding gene Chr3:25938731-25974082 (+)
PWK/PhJ MGP_PWKPhJ_G0026017
protein coding gene Chr3:24878076-24912242 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025828
protein coding gene Chr3:25465908-25501669 (+)
WSB/EiJ MGP_WSBEiJ_G0026358
protein coding gene Chr3:25986823-26020145 (+)



Homology
more
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT2
  • Links
    NCBI Gene ID: 6514
    neXtProt AC: NX_P11168
    UniProt: P11168

  • Chr Location
    3q26.2; chr3:170996341-171026979 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68047
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC2A2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc2a2 mouse models; 1 with human SLC2A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20526 NCBI Gene Model | MGI Sequence Detail 30459 C57BL/6J ±  kb
    transcript NM_031197 RefSeq | MGI Sequence Detail 2571 C57BL/6  
    polypeptide P14246 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015064 solute carrier family 2, facilitated glucose transporter member 2
    • InterPro Domains
      IPR002440 Glucose transporter, type 2 (GLUT2)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 52
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 105
      Diseases 2
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
    • Latest
      J:263547 Li Y, et al., Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response. J Neurosci. 2018 Jun 27;38(26):5872-5887

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory