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Slc2a2
Gene Detail
Symbol

Name
ID
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
MGI:1095438
STS
Synonyms
Glut2, Glut-2, liver-type glucose transporter
Feature Type
protein coding gene
Genetic Map
Chromosome 3
12.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:28697903-28728363 bp, + strand
From VEGA annotation of GRCm38

  30461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC2A2
Gene Tree: Slc2a2

Human
homologs
SLC2A2, solute carrier family 2 (facilitated glucose transporter), member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6514
neXtProt AC: NX_P11168

Human Synonyms: GLUT2

Human Chr (Location): 3q26.1-q26.2; chr3:170995365-171026979 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC2A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.
 
Human Diseases Modeled in Mice Using Slc2a2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Slc2a2 interacts with 159 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (85 records)
Data Summary: Results (72)    Tissues (39)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 57
Northern blot 7
RT-PCR 5
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc2a2 ; ZFIN slc2a2    NEW 
Molecular
reagents
All nucleic(56) Genomic(1) cDNA(51) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035916 (Evidence)
Ensembl Gene Model ENSMUSG00000027690 (Evidence)
Entrez Gene 20526 (Evidence)
UniGene 18443
DFCI TC1580021
DoTS DT.490066, DT.111047157, DT.101221863
NIA Mouse Gene Index U003100
Consensus CDS Project CCDS50880.1
International Mouse Phenotyping Consortium Status Slc2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035916 VEGA Gene Model | MGI Sequence Detail 30461 C57BL/6J ±  kb
transcript OTTMUST00000092113 VEGA | MGI Sequence Detail 2573 Not Applicable 
polypeptide OTTMUSP00000050835 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR002440 Glucose transporter, type 2 (GLUT2)
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015064 solute carrier family 2, facilitated glucose transporter member 2
References
(Earliest) J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
(Latest) J:215816 Brouwers B, et al., Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression. Cell Metab. 2014 Dec 2;20(6):979-90
All references(168)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory