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Slc2a2
Gene Detail
 Symbol
Name
ID
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
MGI:1095438
STS D3Nds12
Synonyms Glut2, Glut-2, liver-type glucose transporter
Feature Type protein coding gene
Genetic Map
Chromosome 3
12.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:28697903-28728356 bp, + strand
From VEGA annotation of GRCm38

  30454 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc2a2

Human
homologs
Human Homolog SLC2A2, solute carrier family 2 (facilitated glucose transporter), member 2
NCBI Gene ID 6514
neXtProt AC  NX_P11168
Human Synonyms  GLUT2
Human Chr (Location)  3q26.1-q26.2; chr3:170996348-171026979 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC2A2
Alleles
and
phenotypes
All alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.
 
Human Diseases Modeled Using Mouse Slc2a2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process carbohydrate transport, carbohydrate utilization, ...
Component basolateral plasma membrane, brush border, ...
Function dehydroascorbic acid transporter activity, D-glucose transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (72)    Tissues (39)    Images (32)
Theiler Stages: 11, 12, 13, 15, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 57
Northern blot 7
RT-PCR 5
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(56) Genomic(1) cDNA(51) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035916 (Evidence)
Ensembl Gene ModelENSMUSG00000027690 (Evidence)
Entrez Gene20526 (Evidence)
UniGene18443
DFCITC1580021
DoTSDT.101221863, DT.111047157, DT.490066
NIA Mouse Gene IndexU003100
Consensus CDS ProjectCCDS50880.1
International Mouse Knockout Project StatusSlc2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035916 VEGA Gene Model | MGI Sequence Detail 30454 C57BL/6J ±  kb
transcript OTTMUST00000092113 VEGA | MGI Sequence Detail 2566 Not Applicable 
polypeptide OTTMUSP00000050835 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR002440 Glucose transporter, type 2 (GLUT2)
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015064 solute carrier family 2, facilitated glucose transporter member 2
References (Earliest) J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
(Latest) J:210632 Lamy CM, et al., Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion. Cell Metab. 2014 Mar 4;19(3):527-38
All references(158)
Other
accession IDs
MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory