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Slc2a2 Gene Detail
Summary
  • Symbol
    Slc2a2
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 2
  • Synonyms
    Glut2, Glut-2, liver-type glucose transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095438
    NCBI Gene: 20526
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:28697903-28731359 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33457 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 12.19 cM
  • Mapping Data
    6 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT2
  • Links
    NCBI Gene ID: 6514
    neXtProt AC: NX_P11168
    UniProt: P11168

  • Chr Location
    3q26.2; chr3:170996341-171026979 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68047
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC2A2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc2a2 mouse models; 1 with human SLC2A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035916 VEGA Gene Model | MGI Sequence Detail 33457 C57BL/6J ±  kb
    transcript OTTMUST00000092113 VEGA | MGI Sequence Detail 5569 Not Applicable  
    polypeptide OTTMUSP00000050835 VEGA | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      371 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015064 solute carrier family 2, facilitated glucose transporter member 2
    • InterPro Domains
      IPR002440 Glucose transporter, type 2 (GLUT2)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 51
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 104
      Diseases 2
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
    • Latest
      J:257633 Jiang FX, et al., Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin. Stem Cells Dev. 2017 Dec 1;26(23):1706-1714

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory