Slc2a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
MGI:1095438

28 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alb^{tm1(cre/ERT2)Mtz}/Alb^{tm1(cre/ERT2)Mtz} Slc2a2^tm2Thor/Slc2a2^tm2Thor involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal bile salt level	J:197607
	abnormal circulating glucose level	J:197607
	abnormal glucose homeostasis	J:197607
	abnormal glycogen homeostasis	J:197607
	abnormal lipid homeostasis	J:197607
	decreased cellular glucose uptake	J:197607
	decreased insulin secretion	J:197607
	decreased liver cholesterol level	J:197607
	decreased liver triglyceride level	J:197607
	normal homeostasis/metabolism phenotype	J:197607
	impaired glucose tolerance	J:197607
	increased liver glycogen level	J:197607
	increased muscle cell glucose uptake	J:197607
Slc2a2^{tm1b(KOMP)Wtsi}/Slc2a2⁺ C57BL/6N-Slc2a2^{tm1b(KOMP)Wtsi}/Rbrc	increased fasting circulating glucose level	J:211773
	increased glycosylated hemoglobin level	J:211773
Slc2a2^{tm1b(KOMP)Wtsi}/Slc2a2^{tm1b(KOMP)Wtsi} C57BL/6N-Slc2a2^{tm1b(KOMP)Wtsi}/Rbrc	preweaning lethality, complete penetrance	J:211773
Slc2a2^tm1Thor/Slc2a2^tm1Thor involves: 129P2/OlaHsd * C57BL/6J	abnormal glucose homeostasis	J:43839
	abnormal glucose tolerance	J:43839
	abnormal lipid homeostasis	J:43839
	abnormal pancreatic islet morphology	J:43839
	decreased body weight	J:43839
	decreased circulating insulin level	J:43839
	decreased pancreas weight	J:43839
	decreased pancreatic beta cell mass	J:43839
	hyperglycemia	J:43839
	increased blood osmolality	J:43839
	increased circulating glucagon level	J:43839
	increased fatty acids level	J:43839
	increased pancreatic alpha cell mass	J:43839
	postnatal lethality, complete penetrance	J:43839

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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