Slc2a2^tm1Thor
Targeted Allele Detail

Summary

• Symbol: Slc2a2^tm1Thor
• Name: solute carrier family 2 (facilitated glucose transporter), member 2; targeted mutation 1, Bernard Thorens
• MGI ID: MGI:2181752
• Synonyms: glut2^-, Slc2a2^delta
• Gene: Slc2a2 Location: Chr3:28752052-28782510 bp, + strand Genetic Position: Chr3, 12.19 cM
• Alliance: Slc2a2^tm1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43839
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5, 6, and 7 were replaced by a neomycin selection cassette. Northern and Western blot analyses of liver tissue showed an absence of transcript and protein in homozygous mutant mice. (J:43839)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a2 Mutation: 31 strains or lines available

References

• Original: J:43839 Guillam MT, et al., Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 [see comments]. Nat Genet. 1997 Nov;17(3):327-30
• All: 15 reference(s)