Bmpr2
Gene Detail

Symbol Name ID

Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) MGI:1095407

Synonyms

2610024H22Rik, BMP-2, BMPRII, BMPR-II

Feature Type

protein coding gene

Genetic Map

Chromosome 1

30.44 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:59764637-59870859 bp, + strand From NCBI annotation of GRCm38   106223 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: type II serine/threonine-protein kinase receptor, Activin/BMP types
Gene Tree: Bmpr2

Human homologs

Human Homolog		BMPR2, bone morphogenetic protein receptor, type II (serine/threonine kinase)
NCBI Gene ID		659
neXtProt AC		NX_Q13873
Human Synonyms		BMPR3, BMPR-II, BMR2, BRK-3, PPH1, T-ALK
Human Chr (Location)		2q33-q34; chr2:203241050-203432474 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human BMPR2

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(3)
 

Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm.

 
Human Diseases Modeled Using Mouse Bmpr2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	anterior/posterior pattern specification, artery development, ...
Component	apical plasma membrane, basal plasma membrane, ...
Function	ATP binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (191)    Tissues (89)    Images (60)
Theiler Stages: 2, 3, 10, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	146
RT-PCR	45

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(9) cDNA(20) Primer pair(4) Other(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000067336 (Evidence)
Entrez Gene	12168 (Evidence)
DFCI	TC1582419, TC1623364, TC1645004, TC1714259, TC1739229, TC1766626
EC	2.7.11.30
Consensus CDS Project	CCDS35588.1
International Mouse Knockout Project Status	Bmpr2

Sequences

Length	Strain/Species
genomic	12168	NCBI Gene Model | MGI Sequence Detail	106223	C57BL/6J
transcript	NM_007561	RefSeq | MGI Sequence Detail	11094	C57BL/6
polypeptide	O35607	UniProt | EBI | MGI Sequence Detail	1038	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(297 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015770	Bone morphogenic protein type II receptor
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000472	TGF-beta receptor/activin receptor, type I/II
Protein Ontology	PR:000000037	BMP receptor type-2

Graphical View of Protein Domain Structure

References

(Earliest) J:1022 Gorecki D, et al., Expression of the dystrophin gene in mouse and rat brain. Neuroreport. 1991 Dec;2(12):773-6
(Latest) J:190182 Gomez-Arroyo J, et al., A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L977-91
All references(95)

Other accession IDs

MGI:1916460, MGI:2138603, MGI:2138646, MGI:3034681