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Bmpr2
Gene Detail
 Symbol
Name
ID
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
MGI:1095407
Synonyms 2610024H22Rik, BMP-2, BMPRII, BMPR-II
Feature Type protein coding gene
Genetic Map
Chromosome 1
30.44 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:59764637-59870859 bp, + strand
From NCBI annotation of GRCm38

  106223 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: type II serine/threonine-protein kinase receptor, Activin/BMP types
Gene Tree: Bmpr2

Human
homologs
Human Homolog BMPR2, bone morphogenetic protein receptor, type II (serine/threonine kinase)
NCBI Gene ID 659
neXtProt AC  NX_Q13873
Human Synonyms  BMPR3, BMPR-II, BMR2, BRK-3, POVD1, PPH1, T-ALK
Human Chr (Location)  2q33-q34; chr2:202376327-202567751 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human BMPR2
Alleles
and
phenotypes
All alleles(10) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm.
 
Human Diseases Modeled Using Mouse Bmpr2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process anterior/posterior pattern specification, artery development, ...
Component apical plasma membrane, basal plasma membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (191)    Tissues (89)    Images (60)
Theiler Stages: 2, 3, 10, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 146
RT-PCR 45
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(9) cDNA(20) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000067336 (Evidence)
Entrez Gene12168 (Evidence)
DFCITC1582419, TC1623364, TC1645004, TC1714259, TC1739229, TC1766626
EC2.7.11.30
Consensus CDS ProjectCCDS35588.1
International Mouse Knockout Project StatusBmpr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12168 NCBI Gene Model | MGI Sequence Detail 106223 C57BL/6J ±  kb
transcript NM_007561 RefSeq | MGI Sequence Detail 11094 C57BL/6 
polypeptide O35607 UniProt | EBI | MGI Sequence Detail 1038 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(590 from dbSNP Build 137)    SNPs within 2kb including multiple locations(594)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR015770 Bone morphogenic protein type II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
Protein Ontology PR:000000037 BMP receptor type-2
Graphical View of Protein Domain Structure
References (Earliest) J:1022 Gorecki D, et al., Expression of the dystrophin gene in mouse and rat brain. Neuroreport. 1991 Dec;2(12):773-6
(Latest) J:209319 Frump AL, et al., Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. PLoS One. 2013;8(11):e80319
All references(112)
Other
accession IDs
MGI:1916460, MGI:2138603, MGI:2138646, MGI:3034681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory