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Bmpr2
Gene Detail
Symbol

Name
ID
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
MGI:1095407
Synonyms
2610024H22Rik, BMP-2, BMPRII, BMPR-II
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.44 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:59763400-59879014 bp, + strand
From VEGA annotation of GRCm38

  115615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: type II serine/threonine-protein kinase receptor, Activin/BMP types
Gene Tree: Bmpr2

Human
homologs
Human Homolog BMPR2, bone morphogenetic protein receptor, type II (serine/threonine kinase)
NCBI Gene ID 659
neXtProt AC  NX_Q13873
Human Synonyms  BMPR3, BMPR-II, BMR2, BRK-3, POVD1, PPH1, T-ALK
Human Chr (Location)  2q33-q34; chr2:202376327-202567751 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human BMPR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm.
 
Human Diseases Modeled Using Mouse Bmpr2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)
Interactions
Bmpr2 interacts with 84 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process anterior/posterior pattern specification, artery development, ...
Component apical plasma membrane, basal plasma membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (249)    Tissues (97)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 146
Western blot 25
RT-PCR 72
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(9) cDNA(20) Primer pair(6) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000047258 (Evidence)
Ensembl Gene ModelENSMUSG00000067336 (Evidence)
Entrez Gene12168 (Evidence)
DFCITC1582419, TC1623364, TC1645004, TC1766626, TC1739229, TC1714259
EC2.7.11.30
Consensus CDS ProjectCCDS35588.1
International Mouse Knockout Project StatusBmpr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047258 VEGA Gene Model | MGI Sequence Detail 115615 C57BL/6J ±  kb
transcript OTTMUST00000122191 VEGA | MGI Sequence Detail 12899 Not Applicable 
polypeptide OTTMUSP00000067108 VEGA | MGI Sequence Detail 1038 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(639 from dbSNP Build 137)    SNPs within 2kb including multiple locations(643)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR015770 Bone morphogenic protein type II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
Protein Ontology PR:000000037 BMP receptor type-2
References
(Earliest) J:1022 Gorecki D, et al., Expression of the dystrophin gene in mouse and rat brain. Neuroreport. 1991 Dec;2(12):773-6
(Latest) J:213435 Gao X, et al., Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS One. 2014;9(2):e89114
All references(119)
Disease annotation references (4)
Other
accession IDs
MGI:1916460, MGI:2138603, MGI:2138646, MGI:3034681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory