75 phenotypes from 9 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bmpr2b2b2556Clo/Bmpr2b2b2556Clo C57BL/6J-Bmpr2b2b2556Clo	abnormal myocardium compact layer morphology	J:175213
	abnormal semilunar valve morphology	J:175213
	atrioventricular septal defect	J:175213
	hydronephrosis	J:175213
	muscular ventricular septal defect	J:175213
	persistent truncus arteriosus type i	J:175213
	persistent truncus arteriosus type iv	J:175213
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl involves: 129S4/SvJae * C57BL/6 * FVB/N	no abnormal phenotype detected	J:97109
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl Tg(Acvrl1-cre)L1Spo/0 involves: 129S4/SvJae * FVB	abnormal lung thrombosis	J:158116
	abnormal lung vasculature morphology	J:158116
	abnormal pulmonary artery morphology	J:158116
	artery occlusion	J:158116
	heart right ventricle hypertrophy	J:158116
	increased lung endothelial cell proliferation	J:158116
	increased pulmonary artery pressure	J:158116
	increased vascular smooth muscle cell proliferation	J:158116
	pulmonary hypertension	J:158116
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl Tg(KRT14-cre)1Ipc/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal hair medulla	J:189569
	abnormal hair medullary septa cells	J:189569
	abnormal hair shaft melanin granule distribution	J:189569
	normal integument phenotype	J:189569
Bmpr2tm1.1Enl/Bmpr2tm1.2Enl H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S4/SvJae * C57BL/6J * CBA/J	abnormal ophthalmic nerve morphology	J:206541
	normal nervous system phenotype	J:206541
Bmpr2tm1.1Enl/Bmpr2tm1Kmi Tg(KRT14-cre)1Ipc/0 involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:189569
Bmpr2tm1.1Pley/Bmpr2+ B6.Cg-Bmpr2tm1.1Pley	normal cardiovascular system phenotype	J:209027
Bmpr2tm1.1Pley/Bmpr2tm1.1Pley B6.Cg-Bmpr2tm1.1Pley	embryonic lethality between implantation and placentation, incomplete penetrance	J:209027
Bmpr2tm1.2Enl/Bmpr2tm1.2Enl involves: 129S4/SvJae * C57BL/6	embryonic growth retardation	J:97109
	embryonic lethality between implantation and somite formation, complete penetrance	J:97109
Bmpr2tm1Enl/Bmpr2tm1Enl involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:97109
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae	abnormal sternocostal joint morphology	J:95124
	vertebral transformation	J:95124
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae * C57BL/6	abnormal lung vasculature morphology	J:98219
	abnormal pulmonary alveolus morphology	J:98219
	abnormal pulmonary artery morphology	J:98219
	increased pulmonary artery pressure	J:98219
	increased pulmonary vascular resistance	J:98219
	pulmonary hypertension	J:98219
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae * C57BL/6J	abnormal leukocyte physiology	J:117167
	abnormal lung vasculature morphology	J:117167
	increased vasoconstriction	J:117167
	perinatal lethality, incomplete penetrance	J:117167
	prenatal lethality, incomplete penetrance	J:117167
	pulmonary hypertension	J:117167
Bmpr2tm1Kmi/Bmpr2tm1Kmi involves: 129S4/SvJae * C57BL/6J	abnormal egg cylinder morphology	J:61931
	abnormal embryonic epiblast morphology	J:61931
	abnormal embryonic-extraembryonic boundary morphology	J:61931
	abnormal rostral-caudal axis patterning	J:61931
	absent mesoderm	J:61931
	disorganized embryonic tissue	J:61931
	disorganized extraembryonic tissue	J:61931
	embryonic growth arrest	J:61931
	embryonic growth retardation	J:61931
	embryonic lethality during organogenesis, complete penetrance	J:61931
	failure of primitive streak formation	J:61931
	failure to gastrulate	J:61931
Bmpr2tm1Kml/Bmpr2tm1Kml either: (involves: 129X1/SvJ * BALB/cJ) or (involves: 129X1/SvJ * C57BL/6J)	abnormal interventricular septum morphology	J:80024
	abnormal semilunar valve morphology	J:80024
	absent vitelline blood vessels	J:80024
	decreased rib number	J:80024
	delayed bone ossification	J:80024
	interrupted aortic arch	J:80024
	lethality throughout fetal growth and development, complete penetrance	J:80024
Bmpr2tm1Mmue/Bmpr2+ B6.129S1-Bmpr2tm1Mmue	abnormal pulmonary artery morphology	J:224752
	increased right ventricle systolic pressure	J:224752
	increased vascular permeability	J:224752
	pulmonary hypertension	J:224752
Bmpr2tm1Mmue/Bmpr2tm1Mmue B6.129S1-Bmpr2tm1Mmue	lethality, complete penetrance	J:224752
Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+ involves: 129 * C57BL/6J	abnormal blood vessel morphology	J:145514
	abnormal pulmonary artery morphology	J:145514
	abnormal spleen morphology	J:145514
	abnormal spleen white pulp morphology	J:145514
	anemia	J:145514
	cachexia	J:145514
	decreased angiogenesis	J:145514
	decreased erythrocyte cell number	J:145514
	enlarged spleen	J:145514
	extramedullary hematopoiesis	J:145514
	normal homeostasis/metabolism phenotype	J:145514
	intestinal hemorrhage	J:145514
	intestine polyps	J:145514
	pallor	J:145514
	premature death	J:145514
	respiratory distress	J:145514
	reticulocytosis	J:145514
	normal skeleton phenotype	J:145514
	vascular smooth muscle hypoplasia	J:145514
Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu involves: 129 * C57BL/6J	gastrointestinal hemorrhage	J:145514
	premature death	J:145514
Tg(Tagln-rtTA)E1Jwst/0 Tg(tetO-Bmpr2*R899X)#Jwst/0 involves: FVB/N	abnormal lung vasculature morphology	J:164503
	heart right ventricle hypertrophy	J:164503
	increased body weight	J:164503
	increased right ventricle systolic pressure	J:164503