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Transgene Detail
Symbol: Tg(tetO-Bmpr2*R899X)#Jwst
Name: transgene insertion, James West
MGI ID: MGI:4838675
Synonyms: TetO7-BMPR2R899X
Transgene: Tg(tetO-Bmpr2*R899X)#Jwst  Location: unknown  
Alliance: Tg(tetO-Bmpr2*R899X)#Jwst page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
Tg(tetO-Bmpr2*R899X)#Jwst expresses 1 gene
Mutation detailsA septad of tetracycline response element with a minimal CMV promoter drive inducible expression of the mouse cDNA with nucleotide substitutions that result in the amino acid substitution of a stop codon for arginine at position 899 (R899X). The cDNA has a C-terminal FLAG tag and is followed by the beta-globin intron and polyadenylation sequence. The amino acid substitution does not alter SMAD activity. No line number or name was provided (designated by #). (J:142266)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:142266 West J, et al., Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory