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Ptch2
Gene Detail
 Symbol
Name
ID
Ptch2
patched homolog 2
MGI:1095405
Synonyms ptc2
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.41 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:117096075-117116101 bp, + strand
From VEGA annotation of GRCm38

  20027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37842  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Ptch2

Human
homologs
Human Homolog PTCH2, patched 2
NCBI Gene ID 8643
neXtProt AC  NX_Q9Y6C5
Human Synonyms  PTC2
Human Chr (Location)  1p34.1; chr1:44819844-44842944 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PTCH2
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a targeted gene disruption display anemia, abnormal red blood cells, enlarged spleens, extramedullary hematopoiesis, and an increased percentage of neutrophils. Most male mice homozygous for another allele display alopecia and skin lesions.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ptch2 interacts with 331 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process epidermis development, hair cycle, ...
Component integral component of membrane, membrane
Function hedgehog family protein binding, hedgehog receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (228)    Tissues (131)    Images (84)
Theiler Stages: 2, 3, 13, 15, 17, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 80
In situ reporter (knock in) 58
Northern blot 2
RT-PCR 88
cDNA source data(27)
External Resources: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(27) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009923 (Evidence)
Ensembl Gene ModelENSMUSG00000028681 (Evidence)
Entrez Gene19207 (Evidence)
UniGene287037
DFCITC1597195, TC1675104
DoTSDT.101720535, DT.485910, DT.94172332
NIA Mouse Gene IndexU004705
Consensus CDS ProjectCCDS18526.1
International Mouse Knockout Project StatusPtch2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009923 VEGA Gene Model | MGI Sequence Detail 20027 C57BL/6J ±  kb
transcript OTTMUST00000023049 VEGA | MGI Sequence Detail 4382 Not Applicable 
polypeptide OTTMUSP00000010515 VEGA | MGI Sequence Detail 1182 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003392 Patched
InterPro IPR000731 Sterol-sensing domain
InterPro IPR004766 Transmembrane receptor, patched
Protein Ontology PR:000013413 protein patched homolog 2
References (Earliest) J:41710 Takabatake T, et al., Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett. 1997 Jun 30;410(2-3):485-9
(Latest) J:210838 Adolphe C, et al., Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol. 2014 Jul;134(7):1981-90
All references(86)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory