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Sftpa1
Gene Detail
Symbol

Name
ID
Sftpa1
surfactant associated protein A1
MGI:109518
Synonyms
Sftp1, Sftp-1, SFTPA1, SP-A, surfactant pulmonary associated protein A1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr14:41131782-41136452 bp, + strand
From VEGA annotation of GRCm38

  4671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: SFTPA1
Gene Tree: Sftpa1

Human
homologs
SFTPA1, surfactant protein A1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 653509
neXtProt AC: NX_Q8IWL2

Human Synonyms: COLEC4, PSAP, PSPA, PSP-A, SFTP1, SFTPA1B, SPA, SP-A, SPA1, SP-A1

Human Chr (Location): 10q22.3; chr10:79610939-79615443 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SFTPA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit impaired lung response to hyperventilation, reduced resistance to pulmonary infections, and enhanced pulmonary inflammatory response to lipopolysaccharide.
 
Interactions
Sftpa1 interacts with 231 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process positive regulation of phagocytosis
Component cytoplasmic vesicle, extracellular space, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (47)    Tissues (15)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 11
Northern blot 8
RT-PCR 8
Nuclease S1 6
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498256    NEW 
Molecular
reagents
All nucleic(45) Genomic(8) cDNA(30) Primer pair(3) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035515 (Evidence)
Ensembl Gene Model ENSMUSG00000021789 (Evidence)
Entrez Gene 20387 (Evidence)
UniGene 46062
DFCI TC1581443, TC1595248
DoTS DT.101381018, DT.97360676, DT.97346243
NIA Mouse Gene Index U015517
Consensus CDS Project CCDS26960.1
International Mouse Phenotyping Consortium Status Sftpa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035515 VEGA Gene Model | MGI Sequence Detail 4671 C57BL/6J ±  kb
transcript OTTMUST00000090956 VEGA | MGI Sequence Detail 851 Not Applicable 
polypeptide OTTMUSP00000050031 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000015945 pulmonary surfactant-associated protein A
References
(Earliest) J:44870 Ten Have-Opbroek AA, Lung development in the mouse embryo. Exp Lung Res. 1991 Mar-Apr;17(2):111-30
(Latest) J:213341 Li W, et al., Pbx1 activates Fgf10 in the mesenchyme of developing lungs. Genesis. 2014 May;52(5):399-407
All references(175)
Other
accession IDs
MGD-MRK-14377, MGD-MRK-14380, MGD-MRK-39517

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory