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Sftpa1 Gene Detail
Summary
  • Symbol
    Sftpa1
  • Name
    surfactant associated protein A1
  • Synonyms
    Sftp1, Sftp-1, SFTPA1, SP-A, surfactant pulmonary associated protein A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109518
    NCBI Gene: 20387
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:41131788-41136373 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.36 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109518
protein coding gene Chr14:41131782-41136452 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021197
protein coding gene Chr14:34763360-34768030 (+)
A/J MGP_AJ_G0021145
protein coding gene Chr14:33415776-33420446 (+)
AKR/J MGP_AKRJ_G0021122
protein coding gene Chr14:34782107-34786777 (+)
BALB/cJ MGP_BALBcJ_G0021149
protein coding gene Chr14:33634210-33638880 (+)
C3H/HeJ MGP_C3HHeJ_G0020932
protein coding gene Chr14:34743899-34748569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021581
protein coding gene Chr14:36161275-36165945 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019143
protein coding gene Chr14:33036870-33041095 (+)
CAST/EiJ MGP_CASTEiJ_G0020457
protein coding gene Chr14:34513514-34518182 (+)
CBA/J MGP_CBAJ_G0020898
protein coding gene Chr14:37390457-37395127 (+)
DBA/2J MGP_DBA2J_G0021021
protein coding gene Chr14:33375532-33380202 (+)
FVB/NJ MGP_FVBNJ_G0021005
protein coding gene Chr14:33312328-33316998 (+)
LP/J MGP_LPJ_G0021090
protein coding gene Chr14:35000584-35005290 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021031
protein coding gene Chr14:37014184-37018854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021614
protein coding gene Chr14:34566215-34570921 (+)
PWK/PhJ MGP_PWKPhJ_G0020205
protein coding gene Chr14:32846235-32850903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020029
protein coding gene Chr14:34190496-34195376 (+)
WSB/EiJ MGP_WSBEiJ_G0020512
protein coding gene Chr14:34681404-34686074 (+)



Homology
more
  • Human Ortholog
    SFTPA1, surfactant protein A1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SFTPA1, surfactant protein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COLEC4, PSAP, PSPA, PSP-A, SFTP1, SFTPA1B, SPA, SP-A, SPA1, SP-A1
  • Links
    NCBI Gene ID: 653509
    neXtProt AC: NX_Q8IWL2
    UniProt: Q8IWL2

  • Chr Location
    10q22.3; chr10:79610939-79615443 (+)  GRCh38.p7

  • Human Ortholog
    SFTPA2, surfactant protein A2
    Orthology source: HGNC
  • Synonyms
    COLEC5, PSAP, PSPA, PSP-A, SFTP1, SFTPA2B, SP-2A, SP-A, SPA2, SPAII
  • Links
    NCBI Gene ID: 729238
    neXtProt AC: NX_Q8IWL1
    UniProt: Q8IWL1

  • Chr Location
    10q22.3; chr10:79555852-79560461 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired lung response to hyperventilation, reduced resistance to pulmonary infections, and enhanced pulmonary inflammatory response to lipopolysaccharide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20387 NCBI Gene Model | MGI Sequence Detail 4586 C57BL/6J ±  kb
    transcript NM_023134 RefSeq | MGI Sequence Detail 2775 C57BL/6  
    polypeptide NP_075623 RefSeq | MGI Sequence Detail 248 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 8
      cDNA 31
      Primer pair 4
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14377, MGD-MRK-14380, MGD-MRK-39517
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 94
      Gene Ontology 3
      Phenotypes 51
    • Earliest
      J:44870 Ten Have-Opbroek AA, Lung development in the mouse embryo. Exp Lung Res. 1991 Mar-Apr;17(2):111-30
    • Latest
      J:263680 Bhatti F, et al., Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PLoS One. 2018;13(7):e0199824

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory