Sftpb
Gene Detail

Symbol Name ID

Sftpb surfactant associated protein B MGI:109516

Synonyms

SF-B, Sftp3, Sftp-3, SP-B

Feature Type

protein coding gene

Genetic Map

Chromosome 6

32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr6:72304625-72312932 bp, + strand From Ensembl annotation of GRCm38   8308 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pulmonary surfactant protein B
Gene Tree: Sftpb

Human homologs

Human Homolog		SFTPB, surfactant protein B
NCBI Gene ID		6439
neXtProt AC		NX_P07988
Human Synonyms		PSP-B, SFTB3, SFTP3, SMDP1, SP-B
Human Chr (Location)		2p12-p11.2; chr2:85884440-85895864 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SFTPB

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Inactivation of this gene results in respiratory failure.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	lipid metabolic process, respiratory gaseous exchange, ...
Component	alveolar lamellar body, cytoplasm, ...

External Resources: FuncBase

Expression

Literature Summary: (90 records)
Data Summary: Results (112)    Tissues (25)    Images (13)
Theiler Stages: 16, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	26
RNA in situ	16
Northern blot	25
Western blot	25
RT-PCR	10
RNase protection	4
Nuclease S1	6

cDNA source data(14)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(4) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056370 (Evidence)
Entrez Gene	20388 (Evidence)
UniGene	46033
DFCI	TC1583587, TC1728722
DoTS	DT.50317127
NIA Mouse Gene Index	U007031
International Mouse Knockout Project Status	Sftpb

Sequences

Length	Strain/Species
genomic	ENSMUSG00000056370	Ensembl Gene Model | MGI Sequence Detail	8308	C57BL/6J
transcript	ENSMUST00000070437	Ensembl | MGI Sequence Detail	1131	Not Applicable
polypeptide	ENSMUSP00000066805	Ensembl | MGI Sequence Detail	376	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008373	Saposin
InterPro	IPR008139	Saposin B
InterPro	IPR011001	Saposin-like
InterPro	IPR007856	Saposin-like type B, 1
InterPro	IPR008138	Saposin-like type B, 2
InterPro	IPR003119	Saposin type A
Protein Ontology	PR:000014773	pulmonary surfactant-associated protein B

References

(Earliest) J:1959 D'Amore-Bruno MA, et al., Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA. Am J Physiol. 1992 Jan;262(1 Pt 1):L40-7
(Latest) J:190719 Joza S, et al., Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
All references(147)

Other accession IDs

MGD-MRK-14379, MGD-MRK-14382, MGD-MRK-39515, MGI:2141447