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Sftpb Gene Detail
Summary
  • Symbol
    Sftpb
  • Name
    surfactant associated protein B
  • Synonyms
    SF-B, Sftp3, Sftp-3, SP-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109516
    NCBI Gene: 20388
Location & Maps
more
  • Sequence Map
    Chr6:72304610-72314371 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    SFTPB, surfactant protein B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SFTPB, surfactant protein B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PSP-B, SFTB3, SFTP3, SMDP1, SP-B
  • Links
    NCBI Gene ID: 6439
    neXtProt AC: NX_P07988

  • Chr Location
    2p12-p11.2; chr2:85657317-85668741 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SFTPB associations

Human Disease Mouse Models
       Surfactant Metabolism Dysfunction, Pulmonary, 1; SMDP1   OMIM: 265120
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Sftpb
  • Incidental Mutations
Inactivation of this gene results in respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044332 VEGA Gene Model | MGI Sequence Detail 9762 C57BL/6J ±  kb
transcript OTTMUST00000116673 VEGA | MGI Sequence Detail 1490 Not Applicable  
polypeptide OTTMUSP00000065042 VEGA | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 4
    cDNA 17
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14379, MGD-MRK-14382, MGD-MRK-39515, MGI:2141447
References
more
  • Summaries
    All 167
    Developmental Gene Expression 114
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:1959 D'Amore-Bruno MA, et al., Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA. Am J Physiol. 1992 Jan;262(1 Pt 1):L40-7
  • Latest
    J:230849 Joshi R, et al., Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung. FASEB J. 2016 Feb;30(2):590-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory