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Sftpb
Gene Detail
Symbol

Name
ID
Sftpb
surfactant associated protein B
MGI:109516
Synonyms
SF-B, Sftp3, Sftp-3, SP-B
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:72304610-72314371 bp, + strand
From VEGA annotation of GRCm38

  9762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: pulmonary surfactant protein B
Gene Tree: Sftpb

Human
homologs
Human Homolog SFTPB, surfactant protein B
NCBI Gene ID 6439
neXtProt AC  NX_P07988
Human Synonyms  PSP-B, SFTB3, SFTP3, SMDP1, SP-B
Human Chr (Location)  2p12-p11.2; chr2:85657317-85668741 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SFTPB
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Inactivation of this gene results in respiratory failure.
 
Interactions
Sftpb interacts with 5 markers (Mir376b, Mir505, Mir876, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process lipid metabolic process, respiratory gaseous exchange, ...
Component alveolar lamellar body, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (102 records)
Data Summary: Results (120)    Tissues (27)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 16
Northern blot 25
Western blot 25
RT-PCR 14
RNase protection 4
Nuclease S1 6
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044332 (Evidence)
Ensembl Gene ModelENSMUSG00000056370 (Evidence)
Entrez Gene20388 (Evidence)
UniGene46033
DFCITC1728722, TC1693608, TC1583587
DoTSDT.50317127, DT.94234031
NIA Mouse Gene IndexU007031
Consensus CDS ProjectCCDS71775.1
International Mouse Knockout Project StatusSftpb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044332 VEGA Gene Model | MGI Sequence Detail 9762 C57BL/6J ±  kb
transcript OTTMUST00000116673 VEGA | MGI Sequence Detail 1490 Not Applicable 
polypeptide OTTMUSP00000065042 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(4) : SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008373 Saposin
InterPro IPR008139 Saposin B
InterPro IPR011001 Saposin-like
InterPro IPR007856 Saposin-like type B, 1
InterPro IPR008138 Saposin-like type B, 2
InterPro IPR003119 Saposin type A
Protein Ontology PR:000014773 pulmonary surfactant-associated protein B
References
(Earliest) J:1959 D'Amore-Bruno MA, et al., Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA. Am J Physiol. 1992 Jan;262(1 Pt 1):L40-7
(Latest) J:206750 Whiteman EL, et al., Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014 Jan;34(1):43-56
All references(161)
Other
accession IDs
MGD-MRK-14379, MGD-MRK-14382, MGD-MRK-39515, MGI:2141447

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory