Ywhaz
Gene Detail

Symbol Name ID

Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide MGI:109484

Synonyms

1110013I11Rik, 14-3-3 zeta

Feature Type

protein coding gene

Genetic Map

Chromosome 15

14.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:36770770-36794547 bp, - strand From VEGA annotation of GRCm38   23778 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhaz

Human homologs

Human Homolog		YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
NCBI Gene ID		7534
neXtProt AC		NX_P63104
Human Synonyms		14-3-3-zeta, HEL4, HEL-S-3, KCIP-1, YWHAD
Human Chr (Location)		8q23.1; chr8:100918576-100953489 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ywhaz interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	histamine secretion by mast cell, protein targeting, ...
Component	blood microparticle, cell leading edge, ...
Function	identical protein binding, poly(A) RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (89)    Tissues (78)    Images (9)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	38
Western blot	4
RT-PCR	47

cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(31) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000017005 (Evidence)
Ensembl Gene Model	ENSMUSG00000022285 (Evidence)
Entrez Gene	22631 (Evidence)
DFCI	TC1573742, TC1657890, TC1670289, TC1680487, TC1721209
DoTS	DT.101130383, DT.110788062, DT.110788070, DT.496289, DT.94299125, DT.94299135, DT.94299163, DT.94299256, DT.97363224, DT.99866762
NIA Mouse Gene Index	U036099, U117070, U143859, U374006
Consensus CDS Project	CCDS27432.1
International Mouse Knockout Project Status	Ywhaz

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017005	VEGA Gene Model | MGI Sequence Detail	23778	C57BL/6J
transcript	OTTMUST00000041230	VEGA | MGI Sequence Detail	2285	Not Applicable
polypeptide	OTTMUSP00000018478	VEGA | MGI Sequence Detail	245	Not Applicable

All sequences(93) RefSeq(8) UniProt(5)

Polymorphisms

SNPs within 2kb(237 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023410	14-3-3 domain
InterPro	IPR000308	14-3-3 protein
InterPro	IPR023409	14-3-3 protein, conserved site
Protein Ontology	PR:000003236	14-3-3 protein zeta/delta

References

(Earliest) J:28983 Suen KL, et al., Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 1995 Sep 7;11(5):825-31
(Latest) J:193468 Min S, et al., Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways. J Immunol. 2013 Mar 1;190(5):2437-46
All references(71)

Other accession IDs

MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160