About   Help   FAQ
Ywhaz
Gene Detail
 Symbol
Name
ID
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
MGI:109484
Synonyms 1110013I11Rik, 14-3-3 zeta
Feature Type protein coding gene
Genetic Map
Chromosome 15
14.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:36770770-36794547 bp, - strand
From VEGA annotation of GRCm38

  23778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhaz

Human
homologs
Human Homolog YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
NCBI Gene ID 7534
neXtProt AC  NX_P63104
Human Synonyms  14-3-3-zeta, HEL4, HEL-S-3, KCIP-1, YWHAD
Human Chr (Location)  8q23.1; chr8:100918576-100953489 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ywhaz interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process histamine secretion by mast cell, protein targeting, ...
Component blood microparticle, cell leading edge, ...
Function identical protein binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (89)    Tissues (78)    Images (9)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 38
Western blot 4
RT-PCR 47
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000017005 (Evidence)
Ensembl Gene ModelENSMUSG00000022285 (Evidence)
Entrez Gene22631 (Evidence)
DFCITC1573742, TC1657890, TC1670289, TC1680487, TC1721209
DoTSDT.101130383, DT.110788062, DT.110788070, DT.496289, DT.94299125, DT.94299135, DT.94299163, DT.94299256, DT.97363224, DT.99866762
NIA Mouse Gene IndexU036099, U117070, U143859, U374006
Consensus CDS ProjectCCDS27432.1
International Mouse Knockout Project StatusYwhaz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017005 VEGA Gene Model | MGI Sequence Detail 23778 C57BL/6J ±  kb
transcript OTTMUST00000041230 VEGA | MGI Sequence Detail 2285 Not Applicable 
polypeptide OTTMUSP00000018478 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000003236 14-3-3 protein zeta/delta
References (Earliest) J:28983 Suen KL, et al., Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 1995 Sep 7;11(5):825-31
(Latest) J:193468 Min S, et al., Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways. J Immunol. 2013 Mar 1;190(5):2437-46
All references(71)
Other
accession IDs
MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory