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Ywhaz Gene Detail
Summary
  • Symbol
    Ywhaz
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Synonyms
    1110013I11Rik, 14-3-3 zeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109484
    NCBI Gene: 22631
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36771014-36797173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109484
 protein coding gene Chr15:36770505-36803228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021798
 protein coding gene Chr15:35187196-35212458 (-)
A/J MGP_AJ_G0021758
 protein coding gene Chr15:33865475-33891527 (-)
AKR/J MGP_AKRJ_G0021738
 protein coding gene Chr15:34819002-34846536 (-)
BALB/cJ MGP_BALBcJ_G0021765
 protein coding gene Chr15:33869443-33897546 (-)
C3H/HeJ MGP_C3HHeJ_G0021539
 protein coding gene Chr15:34770610-34795962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022204
 protein coding gene Chr15:36543427-36565175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019741
 protein coding gene Chr15:31667157-31691303 (-)
CAST/EiJ MGP_CASTEiJ_G0021056
 protein coding gene Chr15:35175854-35199654 (-)
CBA/J MGP_CBAJ_G0021508
 protein coding gene Chr15:37697160-37724665 (-)
DBA/2J MGP_DBA2J_G0021632
 protein coding gene Chr15:33690177-33712049 (-)
FVB/NJ MGP_FVBNJ_G0021610
 protein coding gene Chr15:33090257-33112081 (-)
LP/J MGP_LPJ_G0021702
 protein coding gene Chr15:35091277-35116755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021634
 protein coding gene Chr15:40788951-40814879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022227
 protein coding gene Chr15:34955448-34980761 (-)
PWK/PhJ MGP_PWKPhJ_G0020800
 protein coding gene Chr15:33709202-33733149 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020638
 protein coding gene Chr15:34666650-34690307 (-)
WSB/EiJ MGP_WSBEiJ_G0021111
 protein coding gene Chr15:34931653-34955926 (-)



Homology
more
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Synonyms
    14-3-3-zeta, HEL4, HEL-S-3, HEL-S-93, KCIP-1, POPCHAS, YWHAD
  • Links
    NCBI Gene ID: 7534
    neXtProt AC: NX_P63104
    UniProt: P63104

  • Chr Location
    8q22.3; chr8:100918576-100954068 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Ywhaz mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    82
  • cDNA Data
    26
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022285 Ensembl Gene Model | MGI Sequence Detail 26160 C57BL/6J ±  kb
    transcript ENSMUST00000022894 Ensembl | MGI Sequence Detail 3288 Not Applicable  
    polypeptide ENSMUSP00000022894 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 28
      Primer pair 4
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 20
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:324469 Mugabo Y, et al., 14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells. JCI Insight. 2022 Apr 22;7(8):e156378
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/23/2022
    MGI 6.20     		The Jackson Laboratory