Ywhaz MGI Mouse Gene Detail - MGI:109484 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Ywhaz Gene Detail

Symbol

Ywhaz
Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms

1110013I11Rik, 14-3-3 zeta

Feature Type

protein coding gene
IDs

MGI:109484
NCBI Gene: 22631
Gene Overview

MyGene.info: YWHAZ

Sequence Map

Chr15:36770770-36794547 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

23778 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 14.56 cM
Mapping Data

3 experiments

Human Ortholog

YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Vertebrate Orthologs

10

Human Ortholog

YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Orthology source: HomoloGene, HGNC
Synonyms

14-3-3-zeta, HEL4, HEL-S-3, HEL-S-93, KCIP-1, YWHAD
Links

HGNC:12855

NCBI Gene ID: 7534

neXtProt AC: NX_P63104
Chr Location

8q23.1; chr8:100918576-100954596 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 56528
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: YWHAZ
Protein SuperFamily

14-3-3 protein
Gene Tree

Ywhaz

Diseases

1 with Ywhaz mouse models

Human Disease

Mouse Models

Schizophrenia; SCZD OMIM: 181500

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Gene trapped

17
Targeted

3
Genomic Mutations

2 involving Ywhaz
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects.

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All GO Annotations

36
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

89
Tissues

78
cDNA Data

25
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ywhaz

ZFIN ywhaz

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Ywhaz interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

77
RefSeq

10
UniProt

5
CCDS

CCDS27432.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017005	VEGA Gene Model \| MGI Sequence Detail	23778	C57BL/6J	± kb
transcript	OTTMUST00000041230	VEGA \| MGI Sequence Detail	2285	Not Applicable
polypeptide	OTTMUSP00000018478	VEGA \| MGI Sequence Detail	245	Not Applicable

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SNPs within 2kb

235 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000003236 14-3-3 protein zeta/delta
InterPro Domains

IPR023410 14-3-3 domain

IPR000308 14-3-3 protein

IPR023409 14-3-3 protein, conserved site

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All nucleic 31

cDNA 27

Primer pair 3

Other 1

Microarray probesets 9

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MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160

Summaries

All 71

Developmental Gene Expression 15

Diseases 1

Gene Ontology 13

Phenotypes 15
Earliest

J:28983 Suen KL, et al., Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 1995 Sep 7;11(5):825-31
Latest

J:224441 Lim GE, et al., 14-3-3zeta coordinates adipogenesis of visceral fat. Nat Commun. 2015;6:7671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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