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Ywhaz Gene Detail
Summary
  • Symbol
    Ywhaz
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Synonyms
    1110013I11Rik, 14-3-3 zeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109484
    NCBI Gene: 22631
  • Gene Overview
    MyGene.info: YWHAZ
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:36770770-36794547 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      23778 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.56 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    14-3-3-zeta, HEL4, HEL-S-3, HEL-S-93, KCIP-1, YWHAD
  • Links
    NCBI Gene ID: 7534
    neXtProt AC: NX_P63104
    UniProt: P63104

  • Chr Location
    8q22.3; chr8:100918576-100954068 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Ywhaz mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    89
  • Tissues
    78
  • cDNA Data
    25
  • Literature Summary
    16
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017005 VEGA Gene Model | MGI Sequence Detail 23778 C57BL/6J ±  kb
transcript OTTMUST00000041230 VEGA | MGI Sequence Detail 2285 Not Applicable  
polypeptide OTTMUSP00000018478 VEGA | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 27
    Primer pair 3
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160
References
more
  • Summaries
    All 98
    Developmental Gene Expression 16
    Diseases 1
    Gene Ontology 16
    Phenotypes 22
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:254918 Yang J, et al., 14-3-3zeta loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature. Cell Biosci. 2017;7(None):58
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory