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Itga8
Gene Detail
Symbol

Name
ID
Itga8
integrin alpha 8
MGI:109442
Feature Type
protein coding gene
Genetic Map
Chromosome 2
9.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:12106632-12301920 bp, - strand
From VEGA annotation of GRCm38

  195289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga8

Human
homologs
Human Homolog ITGA8, integrin, alpha 8
NCBI Gene ID 8516
neXtProt AC  NX_P53708
Human Chr (Location)  10p13; chr10:15515712-15720329 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGA8
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
 
Interactions
Itga8 interacts with 410 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell adhesion, cell differentiation, ...
Component apical part of cell, cell surface, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (118)    Tissues (13)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
RT-PCR 2
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(1) cDNA(47) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011364 (Evidence)
Ensembl Gene ModelENSMUSG00000026768 (Evidence)
Entrez Gene241226 (Evidence)
UniGene329997
DFCITC1590580, TC1665622
DoTSDT.526933, DT.101722872
NIA Mouse Gene IndexU040949
Consensus CDS ProjectCCDS15689.1
International Mouse Knockout Project StatusItga8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011364 VEGA Gene Model | MGI Sequence Detail 195289 C57BL/6J ±  kb
transcript OTTMUST00000026594 VEGA | MGI Sequence Detail 5810 Not Applicable 
polypeptide OTTMUSP00000012160 VEGA | MGI Sequence Detail 1062 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(961 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009133 integrin alpha-8
References
(Earliest) J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
(Latest) J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
All references(67)
Other
accession IDs
MGD-MRK-38487, MGI:2138946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory