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Itga8 Gene Detail
Summary
  • Symbol
    Itga8
  • Name
    integrin alpha 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109442
    NCBI Gene: 241226
  • Gene Overview
    MyGene.info: ITGA8
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:12106632-12301920 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 9.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    948 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109442
protein coding gene Chr2:12106632-12301922 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025350
protein coding gene Chr2:9543877-9742035 (-)
A/J MGP_AJ_G0025327
protein coding gene Chr2:9178584-9379926 (-)
AKR/J MGP_AKRJ_G0025296
protein coding gene Chr2:9451435-9654215 (-)
BALB/cJ MGP_BALBcJ_G0025323
protein coding gene Chr2:9159397-9357809 (-)
C3H/HeJ MGP_C3HHeJ_G0025083
protein coding gene Chr2:9412903-9609547 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025765
protein coding gene Chr2:9794950-9998112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023180
protein coding gene Chr2:8676245-8866635 (-)
CAST/EiJ MGP_CASTEiJ_G0024546
protein coding gene Chr2:9362324-9566354 (-)
CBA/J MGP_CBAJ_G0025062
protein coding gene Chr2:10220715-10432507 (-)
DBA/2J MGP_DBA2J_G0025194
protein coding gene Chr2:9057717-9245786 (-)
FVB/NJ MGP_FVBNJ_G0025156
protein coding gene Chr2:8985671-9180590 (-)
LP/J MGP_LPJ_G0025280
protein coding gene Chr2:9450460-9647107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025188
protein coding gene Chr2:10110797-10314603 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025823
protein coding gene Chr2:9359410-9552867 (-)
PWK/PhJ MGP_PWKPhJ_G0024297
protein coding gene Chr2:9001799-9200252 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024097
protein coding gene Chr2:9371979-9568853 (-)
WSB/EiJ MGP_WSBEiJ_G0024616
protein coding gene Chr2:9467490-9670002 (-)



Homology
more
  • Human Ortholog
    ITGA8, integrin subunit alpha 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITGA8, integrin subunit alpha 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8516
    neXtProt AC: NX_P53708
    UniProt: P53708

  • Chr Location
    10p13; chr10:15513949-15720335 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ITGA8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 241226 NCBI Gene Model | MGI Sequence Detail 195289 C57BL/6J ±  kb
    transcript NM_001001309 RefSeq | MGI Sequence Detail 5846 C57BL/6  
    polypeptide A2ARA8 UniProt | EBI | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 49
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38487, MGI:2138946
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 36
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
    • Latest
      J:263065 Ogawa T, et al., Isolation of a unique hepatic stellate cell population expressing integrin alpha8 from embryonic mouse livers. Dev Dyn. 2018 Jun;247(6):867-881

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory