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Itga8 Gene Detail
Summary
  • Symbol
    Itga8
  • Name
    integrin alpha 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109442
    NCBI Gene: 241226
  • Gene Overview
    MyGene.info: ITGA8
Location & Maps
more
  • Sequence Map
    Chr2:12106632-12301922 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      195291 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    ITGA8, integrin subunit alpha 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITGA8, integrin subunit alpha 8
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8516
    neXtProt AC: NX_P53708

  • Chr Location
    10p13; chr10:15513949-15720335 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ITGA8 associations

Human Disease Mouse Models
       Renal Hypodysplasia/Aplasia 1; RHDA1   OMIM: 191830
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011364 VEGA Gene Model | MGI Sequence Detail 195291 C57BL/6J ±  kb
transcript OTTMUST00000026594 VEGA | MGI Sequence Detail 5812 Not Applicable  
polypeptide OTTMUSP00000012160 VEGA | MGI Sequence Detail 1062 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    948 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 51
    Genomic 1
    cDNA 48
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-38487, MGI:2138946
References
more
  • Summaries
    All 65
    Developmental Gene Expression 30
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
  • Latest
    J:224386 Wainwright EN, et al., ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015 Aug 15;404(2):88-102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory