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Itga8
Gene Detail
Symbol

Name
ID
Itga8
integrin alpha 8
MGI:109442
Feature Type
protein coding gene
Genetic Map
Chromosome 2
9.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:12106632-12301922 bp, - strand
From VEGA annotation of GRCm38

  195291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ITGA8
Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga8

Human
homologs
ITGA8, integrin, alpha 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8516
neXtProt AC: NX_P53708

Human Chr (Location): 10p13; chr10:15513949-15720335 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ITGA8

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
 
Interactions
Itga8 interacts with 409 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell adhesion, cell differentiation, ...
Component apical part of cell, cell surface, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (118)    Tissues (13)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
RT-PCR 2
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itga8 ; ZFIN itga8    NEW 
Molecular
reagents
All nucleic(50) Genomic(1) cDNA(47) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011364 (Evidence)
Ensembl Gene Model ENSMUSG00000026768 (Evidence)
Entrez Gene 241226 (Evidence)
UniGene 329997
DFCI TC1590580, TC1665622
DoTS DT.101722872, DT.526933
NIA Mouse Gene Index U040949
Consensus CDS Project CCDS15689.1
International Mouse Phenotyping Consortium Status Itga8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011364 VEGA Gene Model | MGI Sequence Detail 195291 C57BL/6J ±  kb
transcript OTTMUST00000026594 VEGA | MGI Sequence Detail 5812 Not Applicable 
polypeptide OTTMUSP00000012160 VEGA | MGI Sequence Detail 1062 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(961 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009133 integrin alpha-8
References
(Earliest) J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
(Latest) J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
All references(66)
Other
accession IDs
MGD-MRK-38487, MGI:2138946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory