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Atf2 Gene Detail
Summary
  • Symbol
    Atf2
  • Name
    activating transcription factor 2
  • Synonyms
    ATF-2, Creb2, CRE-BP, D130078H02Rik, mXBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109349
    NCBI Gene: 11909
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:73816509-73892639 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109349
protein coding gene Chr2:73816509-73892639 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025841
protein coding gene Chr2:74107154-74194309 (-)
A/J MGP_AJ_G0025819
protein coding gene Chr2:71201849-71282557 (-)
AKR/J MGP_AKRJ_G0025787
protein coding gene Chr2:73143031-73223671 (-)
BALB/cJ MGP_BALBcJ_G0025813
protein coding gene Chr2:71390248-71467113 (-)
C3H/HeJ MGP_C3HHeJ_G0025573
protein coding gene Chr2:73339260-73418325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026260
protein coding gene Chr2:76314117-76404907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023663
protein coding gene Chr2:68628104-68702580 (-)
CAST/EiJ MGP_CASTEiJ_G0025037
protein coding gene Chr2:73617700-73703496 (-)
CBA/J MGP_CBAJ_G0025554
protein coding gene Chr2:79105087-79193199 (-)
DBA/2J MGP_DBA2J_G0025685
protein coding gene Chr2:70792131-70869828 (-)
FVB/NJ MGP_FVBNJ_G0025647
protein coding gene Chr2:70209581-70287066 (-)
LP/J MGP_LPJ_G0025773
protein coding gene Chr2:73989433-74072677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025678
protein coding gene Chr2:81011886-81117796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026317
protein coding gene Chr2:73238449-73319836 (-)
PWK/PhJ MGP_PWKPhJ_G0024778
protein coding gene Chr2:70720072-70797141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024586
protein coding gene Chr2:73468243-73553632 (-)
WSB/EiJ MGP_WSBEiJ_G0025105
protein coding gene Chr2:73692361-73775905 (-)



Homology
more
  • Human Ortholog
    ATF2, activating transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATF2, activating transcription factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREB2, CREB-2, CRE-BP1, HB16, TREB7
  • Links
    NCBI Gene ID: 1386
    neXtProt AC: NX_P15336
    UniProt: P15336

  • Chr Location
    2q31.1; chr2:175072250-175168206 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Atf2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 5 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased postnatal lethality, skeletal development defects, runting, decreased hearing, inner ear and brain abnormalities, hyperactivity, and ataxia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11909 NCBI Gene Model | MGI Sequence Detail 76131 C57BL/6J ±  kb
    transcript NM_001025093 RefSeq | MGI Sequence Detail 4300 C57BL/6  
    polypeptide P16951 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 207
      cDNA 204
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-23723, MGD-MRK-38394, MGI:2139537, MGI:2441951, MGI:2678345
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 23
      Diseases 2
      Gene Ontology 13
      Phenotypes 48
    • Earliest
      J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
    • Latest
      J:255971 Welsbie DS, et al., Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21;94(6):1142-1154.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory