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Atf2
Gene Detail
 Symbol
Name
ID
Atf2
activating transcription factor 2
MGI:109349
Synonyms ATF-2, Creb2, CRE-BP, D130078H02Rik, mXBP
Feature Type protein coding gene
Genetic Map
Chromosome 2
43.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:73816509-73892639 bp, - strand
From VEGA annotation of GRCm38

  76131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic AMP-dependent transcription factor, CRE-BP1 type
Gene Tree: Atf2

Human
homologs
Human Homolog ATF2, activating transcription factor 2
NCBI Gene ID 1386
neXtProt AC  NX_P15336
Human Synonyms  CREB2, CREB-2, CRE-BP1, HB16, TREB7
Human Chr (Location)  2q32; chr2:175072250-175168206 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(74) Targeted(14) Transgenic(1)
Genomic Mutations involving Atf2 (6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased postnatal lethality, skeletal development defects, runting, decreased hearing, inner ear and brain abnormalities, hyperactivity, and ataxia.
 
Phenotype Images(1)
Interactions
Atf2 interacts with 381 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adipose tissue development, cellular response to DNA damage stimulus, ...
Component cytoplasm, membrane, ...
Function cAMP response element binding, cAMP response element binding protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (136)    Tissues (88)    Images (13)
Theiler Stages: 2, 3, 4, 5, 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 108
Northern blot 5
Western blot 2
RT-PCR 19
cDNA source data(194)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(205) cDNA(202) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000013179 (Evidence)
Ensembl Gene ModelENSMUSG00000027104 (Evidence)
Entrez Gene11909 (Evidence)
UniGene209903
DFCITC1576367, TC1583588, TC1588023, TC1592206, TC1594955, TC1606143, TC1715346
DoTSDT.101136302, DT.101381514, DT.101381516, DT.101381517, DT.110698614, DT.110698636, DT.110698643, DT.488504, DT.91302302, DT.91342314, DT.91375433
NIA Mouse Gene IndexU022749
EC2.3.1.48
Consensus CDS ProjectCCDS16134.1, CCDS16135.1, CCDS71076.1
International Mouse Knockout Project StatusAtf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013179 VEGA Gene Model | MGI Sequence Detail 76131 C57BL/6J ±  kb
transcript OTTMUST00000031835 VEGA | MGI Sequence Detail 4210 Not Applicable 
polypeptide OTTMUSP00000014184 VEGA | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(158) RefSeq(34) UniProt(16)
Polymorphisms SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016378 Transcription factor, cyclic AMP-dependent
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004398 cyclic AMP-dependent transcription factor ATF-2
References (Earliest) J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
(Latest) J:204234 Ballas ZK, et al., Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One. 2013;8(6):e65599
All references(96)
Other
accession IDs
MGD-MRK-23723, MGD-MRK-38394, MGI:2139537, MGI:2441951, MGI:2678345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory