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Atf2 Gene Detail
Summary
  • Symbol
    Atf2
  • Name
    activating transcription factor 2
  • Synonyms
    ATF-2, Creb2, CRE-BP, D130078H02Rik, mXBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109349
    NCBI Gene: 11909
Location & Maps
more
  • Sequence Map
    Chr2:73816509-73892639 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76131 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATF2, activating transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATF2, activating transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CREB2, CREB-2, CRE-BP1, HB16, TREB7
  • Links
    NCBI Gene ID: 1386
    neXtProt AC: NX_P15336

  • Chr Location
    2q32; chr2:175072250-175168206 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 5 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    1 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    95
  • Chemically induced (other)
    1
  • Gene trapped
    74
  • Targeted
    19
  • Transgenic
    1
  • Genomic Mutations
    12 involving Atf2
  • Incidental Mutations
Homozygous mutation of this gene results in increased postnatal lethality, skeletal development defects, runting, decreased hearing, inner ear and brain abnormalities, hyperactivity, and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013179 VEGA Gene Model | MGI Sequence Detail 76131 C57BL/6J ±  kb
transcript OTTMUST00000031835 VEGA | MGI Sequence Detail 4210 Not Applicable  
polypeptide OTTMUSP00000014184 VEGA | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 137
Protein
Information
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  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000004398 cyclic AMP-dependent transcription factor ATF-2
  • EC
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029836 cAMP-dependent transcription factor ATF-2
    IPR016378 Transcription factor cyclic AMP-dependent, CRE-BP1-type
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 205
    cDNA 202
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-23723, MGD-MRK-38394, MGI:2139537, MGI:2441951, MGI:2678345
References
more
  • Summaries
    All 97
    Developmental Gene Expression 21
    Gene Ontology 12
    Phenotypes 44
  • Earliest
    J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
  • Latest
    J:226104 Wang F, et al., ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory