Lum
Gene Detail

Symbol

Name
ID

Lum
lumican
MGI:109347

Synonyms

Ldc, SLRR2D

Feature Type

protein coding gene

Genetic Map

Chromosome 10
50.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr10:97565501-97572703 bp, + strand From NCBI annotation of GRCm38   7203 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Lum

Human
homologs

Human Homolog		LUM, lumican
NCBI Gene ID		4060
neXtProt AC		NX_P51884
Human Synonyms		LDC, SLRR2D
Human Chr (Location)		12q21.33; chr12:91103455-91111765 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for targeted disruptions of this gene have abnormally large and aberrantly contoured collagen fibrils forming a disorganized matrix in the tendon, skin, cornea and sclera, with consequent reductions in skin tensile strength and corneal clarity.

 
Human Diseases Modeled in Mice Using Lum (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)

Interactions

Lum interacts with 126 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	collagen fibril organization, positive regulation of transcription from RNA polymerase II promoter, ...
Component	extracellular matrix, extracellular region, ...
Function	collagen binding

External Resources: FuncBase

Expression

Literature Summary: (18 records)

Data Summary: Results (261)    Tissues (37)    Images (30)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	10
RNA in situ	246
Northern blot	3
RT-PCR	2

cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(124) Genomic(4) cDNA(118) Primer pair(1) Other(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000036446 (Evidence)
Entrez Gene	17022 (Evidence)
UniGene	18888
DFCI	TC1622008, TC1572991
DoTS	DT.91432186, DT.101165097, DT.94203057
NIA Mouse Gene Index	U011936
Consensus CDS Project	CCDS24142.1
International Mouse Knockout Project Status	Lum

Sequences

Length	Strain/Species
genomic	17022	NCBI Gene Model | MGI Sequence Detail	7203	C57BL/6J
transcript	NM_008524	RefSeq | MGI Sequence Detail	2075	C57BL/6
polypeptide	P51885	UniProt | EBI | MGI Sequence Detail	338	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(3) : SNPs within 2kb(85 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR027219	Lumican
Protein Ontology	PR:000009981	lumican

Graphical View of Protein Domain Structure

References

(Earliest) J:25176 Chakravarti S, et al., Localization of mouse lumican (keratan sulfate proteoglycan) to distal chromosome 10. Mamm Genome. 1995 May;6(5):367-8
(Latest) J:215414 Chen S, et al., Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly. Matrix Biol. 2014 Apr;35:103-11
All references(79)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-23785, MGD-MRK-38392