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Lum
Gene Detail
Symbol

Name
ID
Lum
lumican
MGI:109347
Synonyms
Ldc, SLRR2D
Feature Type
protein coding gene
Genetic Map
Chromosome 10
50.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:97565501-97572703 bp, + strand
From NCBI annotation of GRCm38

  7203 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LUM
Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Lum

Human
homologs
LUM, lumican
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4060
neXtProt AC: NX_P51884

Human Synonyms: LDC, SLRR2D

Human Chr (Location): 12q21.33; chr12:91103455-91111765 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted disruptions of this gene have abnormally large and aberrantly contoured collagen fibrils forming a disorganized matrix in the tendon, skin, cornea and sclera, with consequent reductions in skin tensile strength and corneal clarity.
 
Human Diseases Modeled in Mice Using Lum (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Lum interacts with 126 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (261)    Tissues (37)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 246
Northern blot 3
RT-PCR 2
cDNA source data(117)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lum ; ZFIN lum    NEW 
Molecular
reagents
All nucleic(124) Genomic(4) cDNA(118) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036446 (Evidence)
Entrez Gene 17022 (Evidence)
UniGene 18888
DFCI TC1622008, TC1572991
DoTS DT.101165097, DT.94203057, DT.91432186
NIA Mouse Gene Index U011936
Consensus CDS Project CCDS24142.1
International Mouse Phenotyping Consortium Status Lum
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17022 NCBI Gene Model | MGI Sequence Detail 7203 C57BL/6J ±  kb
transcript NM_008524 RefSeq | MGI Sequence Detail 2075 C57BL/6 
polypeptide P51885 UniProt | EBI | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR027219 Lumican
Protein Ontology PR:000009981 lumican
Graphical View of Protein Domain Structure
References
(Earliest) J:25176 Chakravarti S, et al., Localization of mouse lumican (keratan sulfate proteoglycan) to distal chromosome 10. Mamm Genome. 1995 May;6(5):367-8
(Latest) J:215414 Chen S, et al., Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly. Matrix Biol. 2014 Apr;35:103-11
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-23785, MGD-MRK-38392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory