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Lum Gene Detail
Summary
  • Symbol
    Lum
  • Name
    lumican
  • Synonyms
    Ldc, SLRR2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:109347
    NCBI Gene: 17022
  • Gene Overview
    MyGene.info: LUM
Location & Maps
more
  • Sequence Map
    Chr10:97565501-97572703 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7203 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.32 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LUM, lumican
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LUM, lumican
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LDC, SLRR2D
  • Links
    NCBI Gene ID: 4060
    neXtProt AC: NX_P51884
    UniProt: P51884

  • Chr Location
    12q21.33; chr12:91103455-91111765 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Lum mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    3 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted disruptions of this gene have abnormally large and aberrantly contoured collagen fibrils forming a disorganized matrix in the tendon, skin, cornea and sclera, with consequent reductions in skin tensile strength and corneal clarity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    282
  • Tissues
    52
  • cDNA Data
    118
  • Literature Summary
    23
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17022 NCBI Gene Model | MGI Sequence Detail 7203 C57BL/6J ±  kb
transcript NM_008524 RefSeq | MGI Sequence Detail 2075 C57BL/6  
polypeptide P51885 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
  • RFLP
    3
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    Genomic 4
    cDNA 119
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23785, MGD-MRK-38392
References
more
  • Summaries
    All 90
    Developmental Gene Expression 23
    Diseases 2
    Gene Ontology 9
    Phenotypes 39
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:236397 Bildsoe H, et al., Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Dev Biol. 2016 Oct 1;418(1):189-203
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/15/2017
MGI 6.10 		The Jackson Laboratory