Prop1
Gene Detail

Symbol Name ID

Prop1 paired like homeodomain factor 1 MGI:109330

Synonyms

Prop-1, prophet of Pit1, prophet of Pit-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

30.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:50950806-50953751 bp, - strand From VEGA annotation of GRCm38   2946 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Prop1

Human homologs

Human Homolog		PROP1, PROP paired-like homeobox 1
NCBI Gene ID		5626
neXtProt AC		NX_O75360
Human Synonyms		CPHD2, PROP-1
Human Chr (Location)		5q35.3; chr5:177419236-177423243 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PROP1

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Homozygotes for a spontaneous mutation exhibit severe proportional dwarfism, hypothyroidism, and sterility. Mutants fail to develop the anterior pituitary cells that secrete growth hormone, prolactin, and thyroid stimulating hormone.

 
Human Diseases Modeled Using Mouse Prop1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	adenohypophysis development, blood vessel development, ...
Component	nucleus, transcription factor complex
Function	beta-catenin binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (27)    Tissues (12)    Images (2)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	23
RT-PCR	2

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(14) cDNA(3) Primer pair(1) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007884 (Evidence)
Ensembl Gene Model	ENSMUSG00000044542 (Evidence)
Entrez Gene	19127 (Evidence)
UniGene	1386
DFCI	TC1592923
DoTS	DT.99848456
NIA Mouse Gene Index	U032734
Consensus CDS Project	CCDS24643.1
International Mouse Knockout Project Status	Prop1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007884	VEGA Gene Model | MGI Sequence Detail	2946	C57BL/6J
transcript	OTTMUST00000017931	VEGA | MGI Sequence Detail	1000	Not Applicable
polypeptide	OTTMUSP00000008241	VEGA | MGI Sequence Detail	223	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000013268	homeobox protein prophet of Pit-1

References

(Earliest) J:64260 Schaible RH, et al., df - Ames dwarf. Mouse News Lett. 1961;25:35
(Latest) J:192776 Gesing A, et al., Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation. Thyroid Res. 2012;5(1):7
All references(150)

Other accession IDs

MGD-MRK-38375, MGD-MRK-8832