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Prop1
Gene Detail
Symbol

Name
ID
Prop1
paired like homeodomain factor 1
MGI:109330
Synonyms
Prop-1, prophet of Pit1, prophet of Pit-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
30.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:50950806-50953765 bp, - strand
From VEGA annotation of GRCm38

  2960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: PROP1
Gene Tree: Prop1

Human
homologs
PROP1, PROP paired-like homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5626
neXtProt AC: NX_O75360

Human Synonyms: CPHD2, PROP-1

Human Chr (Location): 5q35.3; chr5:177992235-177996242 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PROP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
 
Homozygotes for a spontaneous mutation exhibit severe proportional dwarfism, hypothyroidism, and sterility. Mutants fail to develop the anterior pituitary cells that secrete growth hormone, prolactin, and thyroid stimulating hormone.
 
Human Diseases Modeled in Mice Using Prop1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Prop1 interacts with 9 markers (Mir92-2, Mir296, Mir298, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process adenohypophysis development, blood vessel development, ...
Component nucleus, transcription factor complex
Function beta-catenin binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (29)    Tissues (13)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 25
RT-PCR 2
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN prop1    NEW 
Molecular
reagents
All nucleic(23) Genomic(14) cDNA(3) Primer pair(1) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007884 (Evidence)
Ensembl Gene Model ENSMUSG00000044542 (Evidence)
Entrez Gene 19127 (Evidence)
UniGene 1386
DFCI TC1592923
DoTS DT.99848456
NIA Mouse Gene Index U032734
Consensus CDS Project CCDS24643.1
International Mouse Phenotyping Consortium Status Prop1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007884 VEGA Gene Model | MGI Sequence Detail 2960 C57BL/6J ±  kb
transcript OTTMUST00000017931 VEGA | MGI Sequence Detail 1133 Not Applicable 
polypeptide OTTMUSP00000008241 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000013268 homeobox protein prophet of Pit-1
References
(Earliest) J:64260 Schaible RH, et al., df - Ames dwarf. Mouse News Lett. 1961;25:35
(Latest) J:220724 Lee C, et al., IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct;13(5):958-61
All references(156)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-38375, MGD-MRK-8832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory