About   Help   FAQ
Prop1
Gene Detail
 Symbol
Name
ID
Prop1
paired like homeodomain factor 1
MGI:109330
Synonyms Prop-1, prophet of Pit1, prophet of Pit-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
30.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:50950806-50953765 bp, - strand
From VEGA annotation of GRCm38

  2960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Prop1

Human
homologs
Human Homolog PROP1, PROP paired-like homeobox 1
NCBI Gene ID 5626
neXtProt AC  NX_O75360
Human Synonyms  CPHD2, PROP-1
Human Chr (Location)  5q35.3; chr5:177992235-177996242 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PROP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
 
Homozygotes for a spontaneous mutation exhibit severe proportional dwarfism, hypothyroidism, and sterility. Mutants fail to develop the anterior pituitary cells that secrete growth hormone, prolactin, and thyroid stimulating hormone.
 
Human Diseases Modeled Using Mouse Prop1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Prop1 interacts with 9 markers (Mir92-2, Mir296, Mir298, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process adenohypophysis development, blood vessel development, ...
Component nucleus, transcription factor complex
Function beta-catenin binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (27)    Tissues (12)    Images (4)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27
Assay TypeResults
Immunohistochemistry 2
RNA in situ 23
RT-PCR 2
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(14) cDNA(3) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007884 (Evidence)
Ensembl Gene ModelENSMUSG00000044542 (Evidence)
Entrez Gene19127 (Evidence)
UniGene1386
DFCITC1592923
DoTSDT.99848456
NIA Mouse Gene IndexU032734
Consensus CDS ProjectCCDS24643.1
International Mouse Knockout Project StatusProp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007884 VEGA Gene Model | MGI Sequence Detail 2960 C57BL/6J ±  kb
transcript OTTMUST00000017931 VEGA | MGI Sequence Detail 1133 Not Applicable 
polypeptide OTTMUSP00000008241 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000013268 homeobox protein prophet of Pit-1
References (Earliest) J:64260 Schaible RH, et al., df - Ames dwarf. Mouse News Lett. 1961;25:35
(Latest) J:210208 Brown-Borg HM, et al., Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice. Exp Gerontol. 2013 Sep;48(9):905-19
All references(152)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-38375, MGD-MRK-8832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory