Prop1^df
Spontaneous Allele Detail

Summary

• Symbol: Prop1^df
• Name: paired like homeodomain factor 1; Ames dwarf
• MGI ID: MGI:1856842
• Synonyms: Ames^df, df, DW, Prop1^-
• Gene: Prop1 Location: Chr11:50841633-50844584 bp, - strand Genetic Position: Chr11, 30.95 cM
• Alliance: Prop1^df page

Mutation origin

• Strain of Origin: Goodale large mice x pink-eyed stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A T-to-C mutation results in a serine to proline substitution at position 83 (p.S83P) within the alpha1 helix in the homeodomain of the encoded peptide. (J:36967)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	141 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prop1^df

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prop1 Mutation: 15 strains or lines available

Notes

The Ames dwarf mutation arose spontaneously in descendants of a cross of the Goodale large mouse stock to a pink-eyed stock.

References

• Original: J:64260 Schaible RH, et al., df - Ames dwarf. Mouse News Lett. 1961;25:35
• All: 126 reference(s)