Mmp15
Gene Detail

Symbol Name ID

Mmp15 matrix metallopeptidase 15 MGI:109320

Synonyms

Membrane type 2-MMP, MT2-MMP

Feature Type

protein coding gene

Genetic Map

Chromosome 8

47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:95352268-95374293 bp, + strand From VEGA annotation of GRCm38   22026 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp15

Human homologs

Human Homolog		MMP15, matrix metallopeptidase 15 (membrane-inserted)
NCBI Gene ID		4324
neXtProt AC		NX_P51511
Human Synonyms		MT2-MMP, MTMMP2, SMCP-2
Human Chr (Location)		16q13; chr16:58059282-58080805 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	metabolic process, proteolysis
Component	extracellular matrix, integral to membrane, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (105)    Images (39)
Theiler Stages: 11, 12, 13, 22, 23

Assay Type	Results
RNA in situ	127

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027464 (Evidence)
Ensembl Gene Model	ENSMUSG00000031790 (Evidence)
Entrez Gene	17388 (Evidence)
UniGene	217116
DFCI	TC1577095, TC1609924
DoTS	DT.101378577, DT.40148260
NIA Mouse Gene Index	U042922
EC	3.4.24.-
Consensus CDS Project	CCDS22561.1
International Mouse Knockout Project Status	Mmp15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027464	VEGA Gene Model | MGI Sequence Detail	22026	C57BL/6J
transcript	OTTMUST00000067975	VEGA | MGI Sequence Detail	4348	Not Applicable
polypeptide	OTTMUSP00000034288	VEGA | MGI Sequence Detail	657	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro	IPR016293	Peptidase M10A, metazoans
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010475	matrix metalloproteinase-15

References

(Earliest) J:38322 Itoh S, et al., Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Biochim Biophys Acta. 1997 Feb 7;1350(2):155-8
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(42)

Other accession IDs

MGD-MRK-38365, MGI:2142576