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Mmp15
Gene Detail
Symbol

Name
ID
Mmp15
matrix metallopeptidase 15
MGI:109320
Synonyms
Membrane type 2-MMP, MT2-MMP
Feature Type
protein coding gene
Genetic Map
Chromosome 8
47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:95352268-95374293 bp, + strand
From VEGA annotation of GRCm38

  22026 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp15

Human
homologs
Human Homolog MMP15, matrix metallopeptidase 15 (membrane-inserted)
NCBI Gene ID 4324
neXtProt AC  NX_P51511
Human Synonyms  MT2-MMP, MTMMP2, SMCP-2
Human Chr (Location)  16q13; chr16:58025378-58046901 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal phenotype.
 
Interactions
Mmp15 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process proteolysis
Component extracellular matrix, integral component of membrane, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (105)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(75) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027464 (Evidence)
Ensembl Gene ModelENSMUSG00000031790 (Evidence)
Entrez Gene17388 (Evidence)
UniGene217116
DFCITC1577095, TC1609924
DoTSDT.40148260, DT.101378577
NIA Mouse Gene IndexU042922
EC3.4.24.-
Consensus CDS ProjectCCDS22561.1
International Mouse Knockout Project StatusMmp15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027464 VEGA Gene Model | MGI Sequence Detail 22026 C57BL/6J ±  kb
transcript OTTMUST00000067975 VEGA | MGI Sequence Detail 4348 Not Applicable 
polypeptide OTTMUSP00000034288 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010475 matrix metalloproteinase-15
References
(Earliest) J:38322 Itoh S, et al., Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Biochim Biophys Acta. 1997 Feb 7;1350(2):155-8
(Latest) J:213098 Tocchi A, et al., Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May;280(10):2332-41
All references(43)
Other
accession IDs
MGD-MRK-38365, MGI:2142576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory