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Mmp15
Gene Detail
Symbol

Name
ID
Mmp15
matrix metallopeptidase 15
MGI:109320
Synonyms
Membrane type 2-MMP, MT2-MMP
Feature Type
protein coding gene
Genetic Map
Chromosome 8
47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:95352268-95374293 bp, + strand
From VEGA annotation of GRCm38

  22026 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20549  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP15
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp15

Human
homologs
MMP15, matrix metallopeptidase 15 (membrane-inserted)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4324
neXtProt AC: NX_P51511

Human Synonyms: MT2-MMP, MTMMP2, SMCP-2

Human Chr (Location): 16q13; chr16:58025378-58046901 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal phenotype.
 
Interactions
Mmp15 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process proteolysis
Component extracellular matrix, integral component of membrane, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (105)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mmp15 ; ZFIN mmp15a, mmp15b    NEW 
Molecular
reagents
All nucleic(76) cDNA(75) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027464 (Evidence)
Ensembl Gene Model ENSMUSG00000031790 (Evidence)
Entrez Gene 17388 (Evidence)
UniGene 217116
DFCI TC1609924, TC1577095
DoTS DT.101378577, DT.40148260
NIA Mouse Gene Index U042922
EC 3.4.24.-
Consensus CDS Project CCDS22561.1
International Mouse Phenotyping Consortium Status Mmp15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027464 VEGA Gene Model | MGI Sequence Detail 22026 C57BL/6J ±  kb
transcript OTTMUST00000067975 VEGA | MGI Sequence Detail 4348 Not Applicable 
polypeptide OTTMUSP00000034288 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010475 matrix metalloproteinase-15
References
(Earliest) J:38322 Itoh S, et al., Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Biochim Biophys Acta. 1997 Feb 7;1350(2):155-8
(Latest) J:213098 Tocchi A, et al., Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May;280(10):2332-41
All references(43)
Other
accession IDs
MGD-MRK-38365, MGI:2142576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory