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Nudt1 Gene Detail
Summary
  • Symbol
    Nudt1
  • Name
    nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • Synonyms
    8-oxo-7,8-dihydro-2'-dGTPase, Mth1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109280
    NCBI Gene: 17766
  • Gene Overview
    MyGene.info: NUDT1
Location & Maps
more
  • Sequence Map
    Chr5:140321656-140338137 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16482 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NUDT1, nudix hydrolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NUDT1, nudix hydrolase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTH1
  • Links
    NCBI Gene ID: 4521
    neXtProt AC: NX_P36639

  • Chr Location
    7p22; chr7:2242222-2251145 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1839
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NUDT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    64
  • Gene trapped
    58
  • Targeted
    6
  • Incidental Mutations
Aging mice homozygous for a knock-out allele show increased incidence of tumor formation in the lung, liver and stomach.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025895 VEGA Gene Model | MGI Sequence Detail 16482 C57BL/6J ±  kb
transcript OTTMUST00000063807 VEGA | MGI Sequence Detail 952 Not Applicable  
polypeptide OTTMUSP00000031611 VEGA | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38325
References
more
  • Summaries
    All 47
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:29544 Kakuma T, et al., Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J Biol Chem. 1995 Oct 27;270(43):25942-8
  • Latest
    J:210511 Ohno M, et al., 8-oxoguanine causes spontaneous de novo germline mutations in mice. Sci Rep. 2014;4:4689

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory