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Nudt1
Gene Detail
Symbol

Name
ID
Nudt1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
MGI:109280
Synonyms
8-oxo-7,8-dihydro-2'-dGTPase, Mth1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
78.94 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:140331860-140338137 bp, + strand
From VEGA annotation of GRCm38

  6278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NUDT1
Gene Tree: Nudt1

Human
homologs
NUDT1, nudix (nucleoside diphosphate linked moiety X)-type motif 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4521
neXtProt AC: NX_P36639

Human Synonyms: MTH1

Human Chr (Location): 7p22; chr7:2242222-2251145 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(50) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Aging mice homozygous for a knock-out allele show increased incidence of tumor formation in the lung, liver and stomach.
 
Interactions
Nudt1 interacts with 40 markers (Mir18, Mir18b, Mir23a, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nudt1 ; ZFIN nudt1    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025895 (Evidence)
Ensembl Gene Model ENSMUSG00000036639 (Evidence)
Entrez Gene 17766 (Evidence)
DFCI TC1582036
DoTS DT.40186399, DT.97367032, DT.531679
EC 3.6.1.55, 3.6.1.56
Consensus CDS Project CCDS19818.1
International Mouse Phenotyping Consortium Status Nudt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025895 VEGA Gene Model | MGI Sequence Detail 6278 C57BL/6J ±  kb
transcript OTTMUST00000063807 VEGA | MGI Sequence Detail 952 Not Applicable 
polypeptide OTTMUSP00000031611 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003563 7,8-dihydro-8-oxoguanine triphosphatase
InterPro IPR020476 NUDIX hydrolase
InterPro IPR020084 NUDIX hydrolase, conserved site
InterPro IPR000086 NUDIX hydrolase domain
InterPro IPR015797 NUDIX hydrolase domain-like
Protein Ontology PR:000011483 7,8-dihydro-8-oxoguanine triphosphatase
References
(Earliest) J:29544 Kakuma T, et al., Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J Biol Chem. 1995 Oct 27;270(43):25942-8
(Latest) J:210511 Ohno M, et al., 8-oxoguanine causes spontaneous de novo germline mutations in mice. Sci Rep. 2014;4:4689
All references(48)
Other
accession IDs
MGD-MRK-38325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory