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Nudt1
Gene Detail
 Symbol
Name
ID
Nudt1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
MGI:109280
Synonyms 8-oxo-7,8-dihydro-2'-dGTPase, Mth1
Feature Type protein coding gene
Genetic Map
Chromosome 5
78.94 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:140331860-140338137 bp, + strand
From VEGA annotation of GRCm38

  6278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nudt1

Human
homologs
Human Homolog NUDT1, nudix (nucleoside diphosphate linked moiety X)-type motif 1
NCBI Gene ID 4521
neXtProt AC  NX_P36639
Human Synonyms  MTH1
Human Chr (Location)  7p22; chr7:2242222-2251145 (+)  GRCh38
Alleles
and
phenotypes
All alleles(56) : Gene trapped(50) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Aging mice homozygous for a knock-out allele show increased incidence of tumor formation in the lung, liver and stomach.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process ATP catabolic process, dATP catabolic process, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, ...
External Resources: FuncBase
Expression
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025895 (Evidence)
Ensembl Gene ModelENSMUSG00000036639 (Evidence)
Entrez Gene17766 (Evidence)
DFCITC1582036
DoTSDT.40186399, DT.531679, DT.97367032
EC3.6.1.55, 3.6.1.56
Consensus CDS ProjectCCDS19818.1
International Mouse Knockout Project StatusNudt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025895 VEGA Gene Model | MGI Sequence Detail 6278 C57BL/6J ±  kb
transcript OTTMUST00000063807 VEGA | MGI Sequence Detail 952 Not Applicable 
polypeptide OTTMUSP00000031611 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003563 7,8-dihydro-8-oxoguanine triphosphatase
InterPro IPR020476 NUDIX hydrolase
InterPro IPR020084 NUDIX hydrolase, conserved site
InterPro IPR000086 NUDIX hydrolase domain
InterPro IPR015797 NUDIX hydrolase domain-like
Protein Ontology PR:000011483 7,8-dihydro-8-oxoguanine triphosphatase
References (Earliest) J:29544 Kakuma T, et al., Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J Biol Chem. 1995 Oct 27;270(43):25942-8
(Latest) J:193978 Sheng Z, et al., 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest. 2012 Dec 3;122(12):4344-61
All references(48)
Other
accession IDs
MGD-MRK-38325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory