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Eif4ebp2
Gene Detail
 Symbol
Name
ID
Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
MGI:109198
Synonyms 2810011I19Rik, 4E-BP2, PHAS-II
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.21 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:61432497-61452669 bp, - strand
From NCBI annotation of GRCm38

  20173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: eukaryotic translation initiation factor 4E-binding protein
Gene Tree: Eif4ebp2

Human
homologs
Human Homolog EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2
NCBI Gene ID 1979
neXtProt AC  NX_Q13542
Human Synonyms  4EBP2, PHASII
Human Chr (Location)  10q21-q22; chr10:70404105-70428618 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
 
Mice homozygous for a knock-out allele display altered synaptic transmission, impaired spatial learning, and long-term memory deficits, and autism-like behaviors including abnormal social investigation, repetitive behaviors and abnormal vocalization.
 
Human Diseases Modeled Using Mouse Eif4ebp2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Eif4ebp2 interacts with 136 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cAMP-mediated signaling, insulin receptor signaling pathway, ...
Component intracellular
Function eukaryotic initiation factor 4E binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(12)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000020091 (Evidence)
Entrez Gene13688 (Evidence)
DFCITC1578104, TC1714910, TC1720657
Consensus CDS ProjectCCDS23879.1
International Mouse Knockout Project StatusEif4ebp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13688 NCBI Gene Model | MGI Sequence Detail 20173 C57BL/6J ±  kb
transcript NM_010124 RefSeq | MGI Sequence Detail 1786 C57BL/6 
polypeptide P70445 UniProt | EBI | MGI Sequence Detail 120 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008606 Eukaryotic translation initiation factor 4E binding
Protein Ontology PR:000006995 eukaryotic translation initiation factor 4E-binding protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:41738 Pause A, et al., Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function [see comments]. Nature. 1994 27;371(6500):762-7
(Latest) J:208544 Dennis MD, et al., Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes. 2013 Jul;62(7):2204-14
All references(53)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-38242, MGI:1916479, MGI:2143510, MGI:2652850

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory