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Eif4ebp2 Gene Detail
Summary
  • Symbol
    Eif4ebp2
  • Name
    eukaryotic translation initiation factor 4E binding protein 2
  • Synonyms
    2810011I19Rik, 4E-BP2, PHAS-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:109198
    NCBI Gene: 13688
  • Gene Overview
    MyGene.info: EIF4EBP2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61428491-61452661 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.21 cM, cytoband B4-B5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109198
protein coding gene Chr10:61428491-61452790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017280
protein coding gene Chr10:60776907-60797249 (-)
A/J MGP_AJ_G0017258
protein coding gene Chr10:58950529-58973605 (-)
AKR/J MGP_AKRJ_G0017218
protein coding gene Chr10:60493848-60513505 (-)
BALB/cJ MGP_BALBcJ_G0017218
protein coding gene Chr10:59036048-59057252 (-)
C3H/HeJ MGP_C3HHeJ_G0017041
protein coding gene Chr10:60398180-60417674 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017676
protein coding gene Chr10:62937196-62959825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015367
protein coding gene Chr10:55932905-55952041 (-)
CAST/EiJ MGP_CASTEiJ_G0016612
protein coding gene Chr10:60393759-60412324 (-)
CBA/J MGP_CBAJ_G0017013
protein coding gene Chr10:65295244-65323536 (-)
DBA/2J MGP_DBA2J_G0017118
protein coding gene Chr10:58226639-58249387 (-)
FVB/NJ MGP_FVBNJ_G0017112
protein coding gene Chr10:57482302-57503295 (-)
LP/J MGP_LPJ_G0017193
protein coding gene Chr10:61164789-61195313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017140
protein coding gene Chr10:67611268-67630754 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017714
protein coding gene Chr10:60314746-60335956 (-)
PWK/PhJ MGP_PWKPhJ_G0016395
protein coding gene Chr10:58066861-58086394 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016178
protein coding gene Chr10:59663461-59685642 (-)
WSB/EiJ MGP_WSBEiJ_G0016676
protein coding gene Chr10:60233251-60252743 (-)



Homology
more
  • Human Ortholog
    EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    4EBP2, PHASII
  • Links
    NCBI Gene ID: 1979
    neXtProt AC: NX_Q13542
    UniProt: Q13542

  • Chr Location
    10q22.1; chr10:70404105-70428618 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Eif4ebp2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display altered synaptic transmission, impaired spatial learning, and long-term memory deficits, and autism-like behaviors including abnormal social investigation, repetitive behaviors and abnormal vocalization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020091 Ensembl Gene Model | MGI Sequence Detail 24171 C57BL/6J ±  kb
    transcript ENSMUST00000167087 Ensembl | MGI Sequence Detail 1422 Not Applicable  
    polypeptide ENSMUSP00000131952 Ensembl | MGI Sequence Detail 120 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006995 eukaryotic translation initiation factor 4E-binding protein 2
    • InterPro Domains
      IPR008606 Eukaryotic translation initiation factor 4E binding
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38242, MGI:1916479, MGI:2143510, MGI:2652850
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 38
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260731 Ding M, et al., The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. Mol Cancer Res. 2018 Apr;16(4):682-695

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory