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Eif4ebp2tm1Klan
Targeted Allele Detail
Summary
Symbol: Eif4ebp2tm1Klan
Name: eukaryotic translation initiation factor 4E binding protein 2; targeted mutation 1, Eric Klann
MGI ID: MGI:3607258
Synonyms: 4E-BP2 KO
Gene: Eif4ebp2  Location: Chr10:61268276-61288448 bp, - strand  Genetic Position: Chr10, 32.21 cM, cytoband B4-B5
Alliance: Eif4ebp2tm1Klan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102163
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2, disrupting amino acids 49-110. Western blot of hippocampal, cortical and cerebellar extracts confirmed the absence of protein in mutants. (J:102163)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Eif4ebp2tm1Klan
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Eif4ebp2 Mutation:  23 strains or lines available
References
Original:  J:102163 Banko JL, et al., The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005 Oct 19;25(42):9581-90
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory