Sequence Detail

ID/Version

P70445 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 2 {ECO:0000250|UniProtKB:Q13542}; Short=4E-BP2 {ECO:0000250|UniProtKB:Q13542}; Short=eIF4E-binding protein 2 {ECO:0000250|UniProtKB:Q13542};AltName: Full=Phosphoryla

Provider

SWISS-PROT

Sequence

Polypeptide 120 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	26	98	3	22

Sequence references in MGI

J:51748 Lin TA, et al., Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes. J Biol Chem. 1996 Nov 22;271(47):30199-204
J:102163 Banko JL, et al., The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005 Oct 19;25(42):9581-90
J:118038 Le Bacquer O, et al., Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest. 2007 Feb;117(2):387-96
J:128841 Banko JL, et al., Behavioral alterations in mice lacking the translation repressor 4E-BP2. Neurobiol Learn Mem. 2007 Feb;87(2):248-56
J:162956 Bidinosti M, et al., Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell. 2010 Mar 26;37(6):797-808
J:194221 Gkogkas CG, et al., Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17;493(7432):371-7
J:203767 Hartman NW, et al., mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. Cell Rep. 2013 Oct 31;5(2):433-44
J:243830 Olson KE, et al., Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2. Immunology. 2009 Sep;128(1 Suppl):e376-84
J:244821 Dennis MD, et al., Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem. 2013 Jan 04;288(1):10-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89