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Mnx1
Gene Detail
 Symbol
Name
ID
Mnx1
motor neuron and pancreas homeobox 1
MGI:109160
Synonyms HB9, Hlxb9, MNR2
Feature Type protein coding gene
Genetic Map
Chromosome 5
15.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:29473034-29478470 bp, - strand
From VEGA annotation of GRCm38

  5437 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mnx1

Human
homologs
Human Homolog MNX1, motor neuron and pancreas homeobox 1
NCBI Gene ID 3110
neXtProt AC  NX_P50219
Human Synonyms  HB9, HLXB9, HOXHB9, SCRA1
Human Chr (Location)  7q36; chr7:157004853-157010653 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MNX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Radiation induced(3) Targeted(7)
Genomic Mutations involving Mnx1 (3)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice die at birth displaying pancreas dorsal lobe agenesis, small pancreatic islets, and aberrant beta-cell function and motor axon guidance. Mice homozygous for any of three reporter alleles show neonatal death, atelectasis, and impaired motor neuron and pancreas differentiation.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Mnx1 interacts with 155 markers (Mir23b, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell morphogenesis involved in neuron differentiation, central nervous system neuron differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (165 records)
Data Summary: Results (103)    Tissues (86)    Images (31)
Theiler Stages: 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 27, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 80
RT-PCR 7
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037528 (Evidence)
Ensembl Gene ModelENSMUSG00000001566 (Evidence)
Entrez Gene15285 (Evidence)
UniGene103760
DFCITC1588940
DoTSDT.55161103
NIA Mouse Gene IndexU026036
Consensus CDS ProjectCCDS19150.1
International Mouse Knockout Project StatusMnx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037528 VEGA Gene Model | MGI Sequence Detail 5437 C57BL/6J ±  kb
transcript OTTMUST00000096750 VEGA | MGI Sequence Detail 2245 Not Applicable 
polypeptide OTTMUSP00000054092 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010501 motor neuron and pancreas homeobox protein 1
References (Earliest) J:31131 Pfaff SL, et al., Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
(Latest) J:207776 Shen C, et al., Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. J Clin Invest. 2013 Dec 2;123(12):5190-202
All references(227)
Other
accession IDs
MGD-MRK-38204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory