Mnx1
Gene Detail

Symbol Name ID

Mnx1 motor neuron and pancreas homeobox 1 MGI:109160

Synonyms

HB9, Hlxb9, MNR2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

15.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:29473038-29478519 bp, - strand From VEGA annotation of GRCm38   5482 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21137  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Mnx1

Human homologs

Human Homolog		MNX1, motor neuron and pancreas homeobox 1
NCBI Gene ID		3110
neXtProt AC		NX_P50219
Human Synonyms		HB9, HLXB9, HOXHB9, SCRA1
Human Chr (Location)		7q36; chr7:156797547-156803347 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MNX1

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null mice die at birth displaying pancreas dorsal lobe agenesis, small pancreatic islets, and aberrant beta-cell function and motor axon guidance. Mice homozygous for any of three reporter alleles show neonatal death, atelectasis, and impaired motor neuron and pancreas differentiation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell morphogenesis involved in neuron differentiation, central nervous system neuron differentiation, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (152 records)
Data Summary: Results (89)    Tissues (77)    Images (18)
Theiler Stages: 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	80
RT-PCR	7

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) Genomic(1) cDNA(6) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037528 (Evidence)
Ensembl Gene Model	ENSMUSG00000001566 (Evidence)
Entrez Gene	15285 (Evidence)
UniGene	103760
DFCI	TC1588940
DoTS	DT.55161103
NIA Mouse Gene Index	U026036
Consensus CDS Project	CCDS19150.1
International Mouse Knockout Project Status	Mnx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037528	VEGA Gene Model | MGI Sequence Detail	5482	C57BL/6J
transcript	OTTMUST00000096750	VEGA | MGI Sequence Detail	2290	Not Applicable
polypeptide	OTTMUSP00000054092	VEGA | MGI Sequence Detail	404	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000010501	motor neuron and pancreas homeobox protein 1

References

(Earliest) J:31131 Pfaff SL, et al., Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
(Latest) J:192178 Masino MA, et al., TTX-resistant NMDA receptor-mediated membrane potential oscillations in neonatal mouse Hb9 interneurons. PLoS One. 2012;7(10):e47940
All references(209)

Other accession IDs

MGD-MRK-38204